Urinary IGF and IGF binding protein-3 in children with disordered growth

Clinical Endocrinology

Volumn 46, Issue 4, 1997, Pages 483-492

  Gill, M S ^a,b   Whatmore, A J ^a,b   Tillman, V ^a   White, A ^b   Addison, G M ^a   Price, D A ^a   Clayton, P E ^a,b,c  

^a ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c Endocrine Sciences Research Group   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CLONIDINE; GLUCAGON; GROWTH HORMONE; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; RECOMBINANT SOMATOMEDIN B; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ARTICLE; BLOOD LEVEL; CHILD; CREATININE URINE LEVEL; FEMALE; GLOMERULUS FILTRATION; GROWTH DISORDER; GROWTH HORMONE DEFICIENCY; HORMONE URINE LEVEL; HUMAN; IMMUNORADIOMETRIC ASSAY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SHORT STATURE; URINARY EXCRETION; URINE LEVEL;

EID: 0030917472     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1997.1670981.x     Document Type: Article

References (44)

1. Arany, E., Zabel, P., Freeman, D. & Hill, D.J. (1993) Elimination of radiolabelled recombinant human insulin-like growth factor binding protein-3 from the circulation, and its distribution amongst organs and tissues in male rats. Regulatory Peptides, 48, 133-143.
2. Aron, D.C., Rosenweig, J.L. & Abboud, H.A. (1989) Synthesis of insulin-like growth factor-I by human glomerular mesangial cells. Journal of Clinical Endocrinology & Metabolism, 68, 585-591.
3. Ballard, F.H., Knowles, S.E., Walton, P.E., Edson, K., Owens, P.C., Mohler, M.A. & Ferraiola, B.L. (1991) Plasma clearance and tissue distribution of labelled insulin-like growth factor-1 (IGF-I), IGF-II and des(1-3)IGF-I in rats. Journal of Endocrinology, 128, 197-204.
4. Bang, P., Baxter, R.C., Blum, W.F., Breier, B.H., Clemmons, D.R., Hall, K., Hintz, R.L., Holly, J.M.P., Rosenfeld, R.G. & Zapf, J. (1994) Consensus statement: Valid measurements of total IGF concentrations in biological fluids. Recommendations from the 3rd International Symposium on Insulin-like Growth Factors. Journal of Endocrinology, 143, C1-C2.
5. Baxter, R.C. & Martin, J.L. (1986) Radioimmunoassay of growth hormone-dependent insulin-like growth factor binding protein in human plasma. Journal of Clinical Investigation, 78, 1504-1512.
6. Binoux, M., Lalou, C., Lassarre, C. & Segovia, B. (1994) Regulation of IGF bioavailability by IGFBP proteases. In The Insulin-like Growth Factors and their Regulatory Proteins (ed. R. C. Baxter, P.D. Gluckman & R.G. Rosenfeld pp. 217-235. Elsevier Science, New York.
7. Bland, J.M. & Altman, D.G. (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet, i, 307-310.
8. Blum, W.F. & Breier, B.H. (1994) Radioimmunoassays for IGFs and IGFBPs. Growth Regulation, 4 (supplement 1), 11-19.
9. Blum, W.F., Ranke, M.B., Kietzmann, K., Gauggel, E., Zeisel, H.J. & Bierich, J.R. (1990) A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency. Journal of Clinical Endocrinology & Metabolism, 70, 1292-1298.
10. Blum, W.F., Albertsson-Wikland, K., Rosberg, S. & Ranke, M.B. (1993) Serum levels of insulin-like growth factor-I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion. Journal of Clinical Endocrinology & Metabolism, 76, 1610-1616.
11. Bristow, A.F., Gooding, R.P. & Gaines-Das, R.E. (1990) The international reference reagent for insulin-like growth factor-I. Journal of Endocrinology, 125, 191-197.
12. Cianfarani, S., Boemi, S., Spagnoli, A., Cappa, M., Argiro, G., Manca Bitti, M.L. & Boscherini, B. (1995) Is IGF binding protein-3 assessment helpful for the diagnosis of GH deficiency? Clinical Endocrinology, 43, 43-47.
13. Chin, E. & Bondy, C. (1992) Insulin-like growth factor system gent-expression in the human kidney. Journal of Clinical Endocrinology & Metabolism, 75, 962-968.
14. Evans, A.J. & Wood, P.J. (1995) An evaluation of urinary IGFBP-3 measurements in the assessment of short stature in children and of acromegaly in adults. Journal of Endocrinology (supplement), 144, P244.
15. Freeman, J.V., Cole, T.J., Chinn, S., Jones, P.R.M., White, E.M. & Preece, M.A. (1995) Cross-sectional stature and weight reference curves for the UK, 1990. Archives of Diseases in Childhood, 73, 17-24.
16. Gargosky, S.E., Hasegawa, T., Tapanainen, P., MacGillivray, M., Hasegawa, Y. & Rosenfeld, R.G. (1993) Urinary insulin-like growth factors (IGF) and IGF-binding proteins in normal subjects, growth hormone deficiency, and renal disease. Journal of Clinical Endocrinology & Metabolism, 76, 1631-1637.
17. Greulich, W.W. & Pyle, S.I. (1959) Radiographic Atlas of Skeletal Development of Hand and wrist. Stanford University Press, California.
18. Hasegawa, Y., Cohen, P., Yorgin, P. & Rosenfeld, R.G. (1992) Characterization of urinary insulin-like growth factor binding proteins. Journal of Clinical Endocrinology & Metabolism, 74, 830-835.
19. Hasegawa, Y., Hasegawa, T., Aso, T., Kotoh, S., Nose, O., Ohyama, Y., Araki, K., Tanaka, T., Saisyo, S., Yokoya, S., Nishi, Y., Miyamoto, S., Sasaki, N., Kurimoto, F., Stene, M. & Tsuchiya, Y. (1994) Clinical utility of insulin-like growth factor binding protein-3 in the evaluation and treatment of short children with suspected growth hormone deficiency. European Journal of Endocrinology, 131, 27-32.
20. Hizuka, N., Takano, K., Asakawa, K., Miyakawa, M., Horikawa, R. & Shizume, K. (1987) Demonstration of insulin-like growth factor I in human urine. Journal of Clinical Endocrinology & Metabolism, 64, 1309-1312.
21. Hourd, P. & Edwards, R. (1994) Current methods for the measurement of growth hormone in urine. Clinical Endocrinology, 40, 155-170.
22. Jorgensen, J.O.L., Blum, W.F., Moller, N., Ranke, M.B. & Christiansen, J.S. (1990) Circadian patterns of serum insulin-like growth factor (IGF) II and IGF binding protein 3 in growth hormone deficient patients and age- and sex-matched normal subjects. Acta Endocrinologica, 123, 257-262.
23. Juul, A., Bang, P., Hertel, N.T., Main, K., Dalgaard, P., Jørgensen, K., Muller, J., Hall, K. & Skakkebæk, N.E. (1994) Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index. Journal of Clinical Endocrinology & Metabolism, 78, 744-752.
24. Juul, A., Dalgaard, P., Blum, W.F., Bang, P., Hall, K., Michaelson, K.M., Muller, J. & Skakkebæk, N.E. (1995) Serum levels of insulin-like growth factor (IGF) binding protein-3 (1GFBP-3) in healthy infants, children, adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. Journal of Clinical Endocrinology & Metabolism, 80, 2534-2542.
25. Lamson, G., Giudice, L.C. & Rosenfeld, R.G. (1991) A simple assay for proteolysis of IGFBP-3. Journal of Clinical Endocrinology & Metabolism, 72, 1391-1393.
26. Minuto, F., Underwood, L.E., Grimaldi, P., Furlanetto, R.W., Van Wyk, J.J. & Giordano, G. (1981) Decreased somalomedin C concentration during sleep: temporal relationship to nocturnal surges of growth hormone and prolactin. Journal of Clinical Endocrinology & Metabolism, 52, 399-403.
27. Naya, F.J., Strathearn, M.D. & Spencer, E.M. (1991) Tissue expression and chromosomal localization of the human insulin-like growth factor binding protein 3. In Modern Concepts of Insulin-like Growth Factors (ed. E. M. Spencer), pp. 337-342. Elsevier Science, New York.
28. Nunez, S.N., Municchi, G., Barnes, K.M. & Rose, S.R. (1996) Insulin-like growth factor I HGF-I) and IGF-binding protein-3 concentrations compared to stimulated and night growth hormone in the evaluation of short children - a clinical research center study. Journal of Clinical Endocrinology & Metabolism, 81, 1927-1932.
29. Quattrin, T., Albini, C.H., Vandlen, R.L. MacGillivray, M.H. (1987) Quantitation of urinary somatomedin-C in children with normal and abnormal growth. Journal of Clinical Endocrinology & Metabolism, 65, 1168-1171.
30. Quattrin, T., Albini, C.H., Mills, B.J. & MacGillivray, M.H. (1990) Comparison of urinary growth hormone and JGF-J excretion in small- and appropriate-for-gestational-age infants and healthy children. Pediatric Research, 28, 209-212.
31. Ranke, M.B. (1991) The Kabi international growth study: aetiology classification list with comments. Acta Paediatrica Scandanavica (supplement), 379, 87-92.
32. Ratcliffe, S.G., Masera, N., Skinner, A.M., Jones, J., Morrell, D., Pan, H., Price, D.A., Preece, M.A. & Clayton, P.E. (1995) Urinary insulin-like growth factor 1 in normal children: relationship to age, pubertal status and urinary growth hormone. Growth Regulation, 5, 53-59.
33. Rock, R.C., Walker, W.G. & Jennings, C.D. (1987) Nitrogen metabolites and renal function. In Fundamentals of Clinical Chemistry, (Ed. N. W. Tietz), W.B. Saunders, London, pp. 669-704.
34. Rosenfeld, R.G., Wilson, D.M., Lee, P.D.K. & Hintz, R.L. (1986) Insulin-like growth factors I and II in evaluation of growth retardation. Journals of Pediatrics, 109, 428-433.
35. Skinner, A.M., Price, D.A., Addison, G.M., Clayton, P.E., Mackay. R.I., Soo, A. & Mui, C.Y.M. (1992) The influence of age, size, pubertal status and renal factors on urinary growth hormone excretion in normal children and adolescents. Growth Regulation, 2, 156-160.
36. Skinner, A.M., Clayton, P.E., Price, D.A., Addison, G.M. & Soo, A. (1993) Urinary growth hormone excretion in the assessment of children with disorders of growth. Clinical Endocrinology, 39, 201-206.
37. Smith, W.J., Nam, T.J., Underwood, L.E., Busby, W.H., Celnicker, A. & Clemmons, D.R. (1993) Use of insulin-like growth factor binding protein-2 (IGFBP-2), IGFBP-3, and IGF-I for assessing growth hormone status in short children. Journal of Clinical Endocrinology & Metabolism, 77, 1294-1299.
38. Spagnoli, A., Gargosky, S.E., Spadoni, G.L., MacGillivray, M., Oh, Y., Boscherini, B. & Rosenfeld, R.G. (1995) Characterization of a low molecular mass form of insulin-like growth factor binding protein-3 (17.7 kilodaltons) in urine and serum from healthy children and growth hormone (GH)-deficient patients: Relationship with GH therapy. Journal of Clinical Endocrinology & Metabolism, 80, 3668-3676.
39. Tillman, V., Price, D.A., Wales, J.K., Kibirige, M.S., Shalet, S.M., Buckler, J., Addison, G.M., Gill, M.S., Whatmore, A.J. & Clayton, P.E. (1997) Biochemical tests in the diagnosis of childhood growth hormone deficiency. Journal of Clinical Endocrinology & Metabolism, in press.
40. Tönshoff, B., Blum, W.F., Vickers, M., Kurilenko, S., Mehls, O. & Ritz, E. (1995) Quantification of urinary insulin-like growth factors (IGSs) and IGF binding protein 3 in healthy volunteers before and after stimulation with recombinant human growth hormone. European Journal of Endocrinology, 132, 433-137.
41. Yamamoto, H. & Murphy, L.J. (1994) Generation of des(1-3) insulin-like growth factor-I in serum by an acid protease. Endocrinology, 135, 2432-2439.
42. Yamamoto, H. & Murphy, L.J. (1995) N-terminal truncated insulin-like growth factor I in human urine. Journal of Clinical Endocrinology & Metabolism, 80, 1179-1183.
43. Yokoya, S., Suwa, S., Maesaka, H. & Tanaka, T. (1988) Immunoreactive somatomedin-C/insulin-like growth factor I in urine from normal subjects, pituitary dwarfs, and acromegalics. Pediatric Research. 23, 151-154.
44. Zumkeller, W. & Hall, K. (1990) Immunoreactive insulin-like growth factor II in urine. Acta Endocrinologica, 123, 499-503.