Mild to moderate essential hypertension treated with trandolapril: Improvements in circulation and microcirculation

Advances in Therapy

Volumn 14, Issue 2, 1997, Pages 73-88

  Cesarone, M R ^a,b   Belcaro, G ^a   Incandela, L ^a   Laurora, G ^a   De Sanctis, M T ^a   Marelli, C ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b Angiologia e Chir Vascolare Pierangeli Clinic   (Italy)

Author keywords

angiotensin converting enzyme (ACE) inhibitors; hypertension; microcirculation; trandolapril

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; TRANDOLAPRIL;

ADULT; AGED; ANTIHYPERTENSIVE THERAPY; ARTERY DIAMETER; ARTICLE; BLOOD VESSEL REACTIVITY; CIRCULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPPLER FLOWMETRY; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; ESSENTIAL HYPERTENSION; FEMALE; FEMORAL ARTERY; HUMAN; MALE; MICROCIRCULATION; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SKIN BLOOD FLOW;

EID: 0030917450     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Wiseman LR, McTavish D. Trandolapril. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in essential hypertension. Drugs. 1994;48:71-90.
2. Chevillard C, Brown NL, Mathieu MN, Laliberte F, Worcel M. Differential effects of oral trandolapril and enalapril on rat tissue angiotensin-converting enzyme. Eur J Pharmacol. 1988;147:23-28.
3. De Bruijn JHB, Orofiamma BA, Pauly NC, for the Investigator Study Group. Efficacy and tolerance of trandolapril (0.5-2 mg) administered for 4 weeks in patients with mild to moderate essential hypertension. J Cardiovasc Pharmacol. 1994;23(suppl 4):60-64.
4. Cesarone MR, De Sanctis MT, Laurora G, Ambrosoli L, Marelli C, Belcaro G. Effects of trandolapril on 24-h ambulatory blood pressure in patients with mild to moderate essential hypertension. J Cardiovasc Pharmacol. 1994;23(suppl 4):65-72.
5. Bruner CA, Thompson LP, Webb C. Vascular properties in hypertension: structural, functional and cellular changes. In: Machovich R, ed. Blood Vessel Wall and Thrombosis, II. Boca Raton, Fla: CRC Press; 1988:25-29.
6. Lever AF. Slow pressor mechanisms in hypertension: a role for hypertrophy of resistance vessels? J Hypertens. 1986;4:515-524.
7. Laurent S, Arcaro G, Benetos A, Lafleche A, Hoeks A, Safar M. Mechanism of nitrate-induced improvement on arterial compliance depends on vascular territory. J Cardiovasc Pharmacol. 1992;19:641-649.
8. Tooke JE, Williams SA. An evaluation of ketanserin therapy for the hypertensive diabetic patient. In: Program and abstracts of the fourth European meeting on hypertension; June 18-21, 1989; Milan, Italy. Abstract 875.
9. Mulvany MJ, Hansen PK, Aalkjaer C. Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers. Circ Res. 1978;43:854-864.