Effects of pentoxifylline on renal function and blood pressure in cardiac transplant recipients: A randomized trial

Transplantation

Volumn 63, Issue 11, 1997, Pages 1607-1610

  Frantz, Robert P ^a   Edwards, Brooks S ^a   Olson, Lyle J ^a   Schwab, M Kathleen ^a   Adams, Tammy F ^a   Textor, Stephen C ^a   Daly, Richard C ^a   McGregor, C G A ^a   Rodeheffer, Richard J ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; AZATHIOPRINE; CYCLOSPORIN; IOTALAMIC ACID; METHYLPREDNISOLONE; OKT 3; PENTOXIFYLLINE; PLACEBO; PREDNISONE;

ADULT; AGED; ARTICLE; BLOOD PRESSURE MONITORING; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; FEMALE; GLOMERULUS FILTRATION RATE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY FUNCTION TEST; KIDNEY PLASMA FLOW; MALE; NEPHROTOXICITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; BODY WEIGHT; CYCLOSPORINE; DOUBLE-BLIND METHOD; DRUG SYNERGISM; HEART TRANSPLANTATION; HUMANS; HYPERTENSION; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY DISEASES; MIDDLE AGED; PENTOXIFYLLINE; VASODILATOR AGENTS; WEIGHT GAIN;

EID: 0030917433     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199706150-00012     Document Type: Article

References (17)

1. Carrier M, Perrault LP, Trone F, Stewart DJ, Pelletier CL. Pentoxifylline decreases cyclosporine-induced renal endothelin release and vasoconstriction. Ann Thorac Surg 1993; 55: 490.
2. Brunner LJ, Vadiei K, Lyer LV, Luke DR. Prevention of cyclosporine-induced nephrotoxicity with pentoxifylline. Renal Failure 1989; 11: 97.
3. Bianco J, Nemunaitis J, Almgren J, et al. Pentoxifylline diminishes regimen related toxicity in patients undergoing bone marrow transplantation [Abstract]. Blood 1990; 76 (suppl): 528a .
4. Bianco JA, Appelbaum FR, Nemunaitis J, et al. Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation. Blood 1991; 78: 1205.
5. Hunt SA, Gamberg P, Stinson EB, Oyer PE, Shumway NE. The Stanford experience: survival and renal function in the pre-Sandimmune era compared to the Sandimmune era. Transplant Proc 1990; 22 (suppl 1): 1.
6. Hayashi Y, Shibata N, Minouchi T, Shibata H, Ono T, Shimakawa H. Evaluation of fluorescence polarization immunoassay for determination of cyclosporin in plasma. Ther Drug Monit 1989; 11: 205.
7. Mason J. Renal side-effects of cyclosporine. Transplant Proc 1990; 3: 1280.
8. 2) by pentoxifylline from human vascular tissue. Arzneimittelforschung 1982; 32: 1315.
9. Hoeffner U, Aarhus LL, Katusic ZS, Vanhoutte PM. Pharmacology of pentoxifylline in isolated canine arteries and veins. J Cardiovasc Pharmacol 1989; 14: 899.
10. Carrier M, Pelletier GB, White M, Bois D, Pelletier LC. Effect of pentoxifylline on renal toxicity of cyclosporine: results of a clinical trial after heart transplantation. J Heart Lung Transplant 1996; 15: 1179.
11. White JR, Rockwood T, Wilson D, Bettesworth L, Icenogle T. The effects of pentoxifylline on the prevention of cyclosporine-induced nephrotoxicity in cardiac transplant patients. Clin Ther 1994; 16: 673.
12. Attal M, Huguet F, Rubie H, et al. Prevention of regimen-related toxicities after bone marrow transplantation by pentoxifylline: a prospective, randomized trial. Blood 1993; 82: 732.
13. Clift RA, Bianco JA, Appelbaum FR, et al. A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplantation. Blood 1993; 82: 2025.
14. Konigsrainer A, Aichberger C, Riedmann B, Steurer W, Ofner D, Margreiter R. Pentoxifylline as an adjunct to cyclosporine-based immunosuppression does not improve the outcome of renal transplantation. Transplant Proc 1995; 27: 1062.
15. Gonwa TA, Mai ML, Pilcher J, et al. Stability of long-term renal function in heart transplant patients treated with induction therapy and low-dose cyclosporine. J Heart Lung Transplant 1992; 11: 926.
16. Radovancevic B, Birovljev S, Frazier OH, et al. Long-term follow-up of cyclosporine-treated cardiac transplant recipients. Transplant Proc 1990; 22 (suppl 1): 21.
17. Burke JF, Pirsch JD, Ramos EL, et al. Long-term efficacy and safety of cyclosporine in renal-transplant recipients. N Engl J Med 1994; 331: 358.