The identification and purification of a novel mammalian DNA ligase

Mutation Research - DNA Repair

Volumn 383, Issue 3, 1997, Pages 205-212

  Johnson, Andrew P ^a   Fairman, Micaela P ^a  

^a MRC Radiat and Genome Stability U   (United Kingdom)

Author keywords

Cell free extract; DNA strand breaks, rejoining of; Mammalian DNA ligase

Indexed keywords

CELL EXTRACT; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ARTICLE; DNA STRAND BREAKAGE; ENZYME ANALYSIS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; CELL LINE; CELL NUCLEUS; CHROMATOGRAPHY; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, ION EXCHANGE; DNA DAMAGE; DNA LIGASES; DNA REPAIR; DURAPATITE; HUMANS; KIDNEY; MAMMALS; MOLECULAR WEIGHT; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 0030917377     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(97)00003-7     Document Type: Article

References (17)

1. Lindahl, T. (1993) Instability and decay of the primary structure of DNA, Nature, 362, 709-715.
2. Frankenberg, D., M. Frankenberg-Schwager, D. Blocher and H. Harbich (1981) Evidence for DNA double strand breaks as the critical lesions in yeast cells irradiated with sparsely or densely ionizing radiation under oxic or anoxic conditions, Radiat. Res., 88, 524-532.
3. Bennett, C.B., T.J. Westmoreland, J.R. Snipe and M.A. Resnick, (1996) A double-strand break within a Yeast Artificial Chromosome (YAC) containing human DNA can result in YAC loss, deletion, or cell lethality, Mol. Cell Biol., 16, 4414-4425.
4. Tomkinson, A.E., E. Roberts, G. Daly, N. Totty and T. Lindahl (1991) Three distinct DNA ligases in mammalian cells, J. Biol. Chem., 266, 21728-21735.
5. Wei, Y.-F., P. Robins, K. Carter, K. Caldecott, D.J. Pappin, G.-L. Yu, R.-P. Wang, B.K. Shell, R.N. Nash, P. Schar, D.E. Barnes, W.A. Haseltine and T. Lindahl (1995) Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination, Mol. Cell Biol., 15, 3206-3216.
6. Fairman, M.P., A.P. Johnson and J. Thacker (1992). Multiple components are involved in the efficient joining of double strand breaks in human cell extracts, Nucleic Acids Res., 20, 4115-4352.
7. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680-686.
8. Sambrook, K., E.F. Fritsch and T. Maniatis (1982) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, New York.
9. Arrand, J.E., A.E. Willis, I. Goldsmith and T. Lindahl (1986) Different substrate specificities of the two DNA ligases of mammalian cells, J. Biol. Chem. 261, 9079-9082.
10. Lindahl, T. and D.E. Barnes (1992) Mammalian DNA ligases, Annu. Rev. Biochem., 61, 251-281.
11. Malkas, L.H., R.J. Hickey, C. Li, N. Pedersen and E.F. Baril (1990) A 21S enzyme complex from Hela cells that functions in SV40 replication in vitro, Biochemistry, 29, 6362-6374.
12. Waga, S., G. Bauer and B. Stillman (1994) Reconstitution of complete SV40 DNA replication with purified replication factors, J. Biol. Chem., 269, 10923-10929.
13. Creissen, D. and S. Shall (1982) Regulation of DNA ligase activity by poly(ADP-ribose), Nature, 296, 271-272
14. Wang, Y.-C., W.A. Burkhart, Z.B. Mackey, M.B. Moyer, W. Ramos, I. Husain, J. Chen, J.M. Besterman and A.E. Tomkinson (1994) Mammalian DNA ligase II is highly homologous with Vaccinia DNA ligase, J. Biol. Chem., 269, 31923-31928.
15. Caldecott, K.W., C.K. McKeown, J. Tucker, S. Ljungquist and L.H. Thompson (1994) An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III, Mol. Cell Biol., 14, 68-76.
16. Caldecott, K.W., C.K. McKeown, J. Tucker, L. Stanker and L.H. Thompson (1995) Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells, Nucleic Acids Res., 23, 4836-4843.
17. Jackson, S.P. and P.A. Jeggo (1995) DNA double strand break repair and V(D)J recombination:involvement of DNA-PK, Trends Biol. Sci., 20, 413-441.