Pharmacokinetics of lercanidipine in animals. II. Distribution to and elimination from organs and tissues after administration of [14C]lercanidipine to rats and dogs: Whole-body autoradiography, biliary excretion and enterohepatic circulation and biotransformation in rats

Journal of Cardiovascular Pharmacology

Volumn 29, Issue SUPPL. 1, 1997, Pages

  Farina, P ^a   Targa, G ^a   Leoni, B ^a   Tajana, A ^a  

^a Recordati SpA   (Italy)

Author keywords

1,4 Dihydropyridine derivatives; Biotransformation; Calcium antagonists; Lercanidipine, tissue distribution, biliary excretion; Zanidip

Indexed keywords

DIHYDROPYRIDINE DERIVATIVE; LERCANIDIPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; AUTORADIOGRAPHY; BILIARY EXCRETION; DATA ANALYSIS; DOG; DOSE RESPONSE; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG TRANSFORMATION; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; TISSUE DISTRIBUTION;

EID: 0030917243     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199729001-00013     Document Type: Article

References (6)

1. Sironi G, Montagna E, Greto L, Bianchi G, Leonardi A, Testa R. Antihypertensive effects of lercanidipine in experimental hypertensive rats and dogs. Arzneimittelforschung 1996;46:145-52.
2. Farina P, Targa G, Tajana A, Leoni B. Enantiomeric LC determination of lercanidipine, in plasma. Proc Fifth International Symposium on Chiral Discrimination. Stockholm, Sweden, Sept. 1994, ACC;118:83.
3. Statistical Consultants Inc. PCNONLIN and NONLIN 84: Software for the Statistical Analysis of Nonlinear Models. Am Statistician 1986;401:52.
4. Kobayashi H, Kobayashi S, Inoue A, Nakamizo N. Pharmacokinetic study of benidipine hydrochloride in rats and dogs. Arzneimittelforschung 1988;38:1750-53.
5. 3H]nitrendipine binding sites. Arzneimittelforschung 1988;38:1681-83.
6. Herbette LG, Vant Erve YMG, Rhodes DG. Interaction of 1,4 dihydropyridine calcium channel antagonists with biological membranes: lipid bilayer partitioning could occur before drug binding to receptors. J Mol Cell Cardiol 1989;21: 187-201.