QSAR analysis of 2-alkyloxy and 2-aralkyloxy adenosine A1- and A2-agonists

European Journal of Medicinal Chemistry

Volumn 32, Issue 6, 1997, Pages 505-513

  Matova, M ^a   Nacheva, R ^a   Boicheva, S ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

2 Alkyloxy adenosine; 2 Aralkyloxy adenosine; 3 D electronic structure descriptor; A1 adenosine agonist; A2 adenosine agonist; QSAR; Van der Waals volume

Indexed keywords

ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; RECEPTOR SUBTYPE;

ARTICLE; CALCULATION; CLUSTER ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUANTUM CHEMISTRY; RECEPTOR AFFINITY; REGRESSION ANALYSIS; THEORY;

EID: 0030916987     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(97)84013-5     Document Type: Article

References (34)

1. Styles GL (1992) J Biol Chem 267 (10), 6451-6454
2. Daly JW (1982) J Med Chem 25 (3), 197-207
3. Hoflack J, Trumpp-Kallmeyer S, Hibert M (1993) In: 3-D QSAR in Drug Design, Theory, Methods and Aplications (Kubinyi H, ed) ESCOM Sci Publ BV, Leiden, The Netherlands, 355-371
4. Palmer TM, Stiles GL (1995) Neuropharmacology 34 (7), 683-694
5. Jacobson KA, Van Galen PJM, Olah ME, Styles GL (1993) Drug Dev Res 28, 226-231
6. Van Galen PJM, Stiles GL, Michaels G, Jacobson KA (1992) Med Res Rev 12 (5), 423-471
7. Jacobson KA, Van Galen PJM, Williams M (1992) J Med Chem 35 (3), 407-422
8. IJzerman AP, Van Galen PJM, Jacobson KA (1992) Drug Des Discov 9, 49-67
9. Pirovano IM, IJzerman AP, Van Galen PJM, Soudijn W (1989) Eur J Pharmacol Mol Pharmacol 172, 185-193
10. Dudley MW, Peet NP, Demeter DA et al (1993) Drug Dev Res 28, 237-243
11. Van der Wenden EM, Price SL, Apaya RP, IJzerman AP, Soudijn W (1995) J Comput Aided Mol Des 9, 44-54
12. Mager PP (1994) Eur J Med Chem 29, 369-380
13. Mager PP, Richter M, Reinhard R (1995) Eur J Med Chem 30, 15-25
14. Daly JW, Padgett W, Thompson RD, Kusachi S, Bugni WJ, Olsson RA (1986) Biochem Pharmacol 35, 2467-2481
15. Ueeda M, Thompson RD, Arroyo LH, Olsson RA (1991) J Med Chem 34, 1334-1339
16. Ueeda M, Thompson RD, Arroyo LH, Olsson RA (1991) J Med Chem 34, 1340-1344
17. Olsson RA, Thompson RD, Ueeda M, Arroyo LH (1991) Nucleosides Nucleotides 10(5), 1049-1055
18. Daly JW, Padgett WL, Secunda SI, Thompson RD, Olsson RA (1993) Pharmacology 46, 91-100
19. Cristalli G, Frachetti P, Grifantini M, Vittori S, Klotz KN, Lohse MJ (1988) J Med Chem 31, 1179-1183
20. Van de Waterbeemd H (1992) Quant Struct Act Relat 11 (2), 200-204
21. Stewart JJP (1992) J Comput Aided Mol Des 4 (1), 1-103
22. Dewar MJS, Zoebisch EG, Healy EF, Stewart JJP (1985) J Am Chem Soc 107, 3902-3909
23. Fletcher R, Reeves CM (1964) Comput J 7, 149-154
24. Van Galen PJM, IJzerman AP, Soudijn W (1990) Nucleosides Nucleotides 9, 275-291
25. HyperChem™ 2 (1991) Hyper-cube Inc; Autodeck, Inc
26. Jurs PC, Dixon SL, Egolf LM (1995) In: Chemometric Methods in Molecular Design (van de Waterbeemd H, ed) VCH Weinheim, Germany, 25-35
27. CHEMX, CDL (Chemical Design Ltd), Oxford, UK
28. Mekenyan O, Bonchev D (1986) Acta Pharm Jugosl 36, 225-237
29. Silipo C, Vittoria A (1990) In: Comprehensive Medicinal Chemistry (C Hansch, ed) Pergamon Press, Oxford, 154-200
30. Miller JC, Miller JN (1993) In: Statistics for Analytical Chemistry (M Masson, J Tyson, P Stockwell, eds) Ellis Horwood PTR Prentice Hall, London, 3rd edn, 167-201
31. SYSTAT. Systat Inc, 1800 Sherman Ave, Evanston, IL, USA
32. StatView512+™, ver 1.1 (1986) from Abacus Concepts Inc, publ by Brain Power Inc
33. Van Galen PJM, Leusen FJJ, Uzerman AP, Soudijn W (1989) Eur J Pharmacol Mol Pharmacol 172, 19-27
34. Murray RK, Granner DK, Mayes PA, Rodwell VW (1993) In: Harper's Biochemistry (Murray RK, Granner DK, Mayes PA, Rodwell VW, eds) Prentice Hall International Inc, USA, 23rd edn, 353-362