Electrophysiologic study of lercanidipine and its enantiomers

Journal of Cardiovascular Pharmacology

Volumn 29, Issue SUPPL. 1, 1997, Pages

  Cerbai, Elisabetta ^a   Barbieri, Mario ^b   Mugelli, Alessandro ^a,c  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c Department of Pharmacology ^*  (Italy)

Author keywords

Calcium antagonists; Dihydropyridines; Enantiomers; Lercanidipine

Indexed keywords

DIHYDROPYRIDINE DERIVATIVE; LERCANIDIPINE; NIFEDIPINE; NIMODIPINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DATA ANALYSIS; ENANTIOMER; GUINEA PIG; HYPERTENSION; INOTROPISM; MEMBRANE POTENTIAL; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; SODIUM CURRENT; STEADY STATE; SWINE;

EID: 0030916716     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199729001-00002     Document Type: Article

References (24)

1. Weber MA, Graettinger WF. Calcium channel blockers as hypotensive agents. In: Singh BN, Dzau VJ, Vanhoutte PM, Woosley RL, eds. Cardiovascular pharmacology and therapeutics. New York: Churchill Livingston, 1994:931-44.
2. 2+ channel antagonists. Trends Pharmacol Sci 1992;13:256-62.
3. Nayler WG. Calcium antagonists. London: Academic Press, 1988.
4. Guarneri L, Angelico P, Ibba M, et al. Pharmacological in vitro studies of the new 1,4-dihydropyridine calcium antagonist lercanidipine. Arzneimittelforschung 1996;46:15-24.
5. Sironi G, Montagna E, Greto L, Bianchi G, Leonardi A, Testa R. Antihypertensive effects of lercanidipine in experimental hypertensive rats and dogs. Arzneimittelforschung 1996;46: 145-52.
6. Bianchi G, Passoni A, Griffini PL. Effects of a new calcium antagonist, Rec 15/2375, on cardiac contractility of conscious rabbits. Pharmacol Res 1989;21:193-200.
7. Sironi G, Montagna E, Greto L, Leonardi A, Testa R. Haemodynamic effects of lercanidipine in anaesthetized open-chest dogs. Arzneimittelforschung 1996;46:256-61.
8. Cerbai E, De Bonfioli Cavalcabò P, Masini I, Visentin S, Giotti A, Mugelli A. Cardiac electrophysiology of a new calcium antagonist, lacidipine. J Cardiovasc Pharmacol 1990;15:604-9.
9. Barbieri M, Masini I, Porciatti F, Cerbai E, Mugelli A. Cardiac electrophysiological effects of a new dihydropyridine calcium antagonist (BBR 2160). Pharmacol Res 1991;23:87-94.
10. Ferrari R, Di Lisa F, de Jong JW, et al. Prolonged propionyl-1-carnitine treatment of rabbit: biochemical, haemodynamic and electrophysiological effects on myocardium. J Mol Cell Cardiol 1992;24:219-32.
11. Cerbai E, Ambrosio G, Porciatti F, Chiariello M, Giotti A, Mugelli A. Cellular electrophysiological basis for oxygen radicalinduced arrhythmias: a patch-clamp study in guinea-pig ventricular myocytes. Circulation 1991;84:1773-82.
12. Guerra L, Cerbai E, Gessi S, Borea PA, Mugelli A. The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricular myocytes. Br J Pharmacol 1996;118:1278-84.
13. f, in ventricular myocytes isolated from hypertensive rats. J Physiol (Lond) 1994;481:585-91.
14. Sanguinetti MC, Kass RS. Voltage-dependent block of calcium channel current in the calf Purkinje fiber by dihydropyridine calcium channel antagonists. Circ Res 1984;55:336-48.
15. Kass RS, Arena JP. Membrane potential and dihydropyridine block of calcium channels in the heart: influence of drug ionization on blocking activity. In: Morad M, Nayler W, Kazda S, Schramm M, eds. The calcium channel: structure, function and implications. Berlin: Springer-Verlag, 1988:81-91.
16. Lee KS, Tsien RW. Mechanism of calcium channel blockade by verapamil, D-600, diltiazem and nitrendipine in single dialyzed heart cells. Nature 1983;302:790-4.
17. 2+ channels by three dihydropyridines with different structural features: potential-dependent blockade by Ro 18-3981. Br J Pharmacol 1987;91:61-7.
18. Kass RS, Arena JP. Influence of pHo on calcium channel block by amlodipine, a charged dihydropyridine compound: implications for location of the dihydropyridine receptor. J Gen Physiol 1989;93:1109-27.
19. Kamp TJ, Sanguinetti MC, Miller RJ. Voltage- and use-dependent modulation of cardiac calcium channels by the dihydropyridine (+)-202-791. Circ Res 1989;64:338-51.
20. Schramm M, Thomas G, Towart R. Novel dihydropyridines with positive inotropic actions through activation of Ca channels. Nature 1983;303:535-7.
21. Hof RP, Ruegg UT, Hof A, Vogel A. Stereoselectivity at the calcium channel: opposite action of enantiomers of a 1,4-dihydropyridine. J Cardiovasc Pharmacol 1985;7:689-93.
22. Schwartz A, Grupp IL, Grupp G, Williams JS, Vaghy PL. Effects of dihydropyridine calcium channel modulators in the heart: pharmacological and radioligand binding correlations. Biochem Biophys Res Commun 1984;125:387-94.
23. Hume JR, Uehara A. Ionic basis of the different action potential configurations of single guinea-pig atrial and ventricular myocytes. J Physiol (Lond) 1985;368:525-44.
24. Kokubun S, Prod'hom B, Becker C, Porzig H, Reuter H. Studies on Ca channels in intact cardiac cells: voltage-dependent effect and cooperative interactions of dihydropyridine enantiomers. Mol Pharmacol 1986;30:571-84.