Relationship between amount of β-blockers permeating through the stratum corneum and skin irritation after application of β-blocker adhesive patches to guinea pig skin

Biological and Pharmaceutical Bulletin

Volumn 20, Issue 4, 1997, Pages 421-427

  Kobayashi, Ichiro ^a   Hosaka, Kyoko ^a   Ueno, Takashi ^a   Maruo, Hiroki ^a   Kamiyama, Masashi ^a   Konno, Chohachi ^a   Gemba, Munekazu ^b  

^a NITTO DENKO CORPORATION   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

chromameter a* value; skin irritation; stratum corneum; blocker

Indexed keywords

ACEBUTOLOL; ALPRENOLOL; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; OXPRENOLOL; TIMOLOL;

ANIMAL EXPERIMENT; ARTICLE; CORRELATION FUNCTION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; GUINEA PIG; LIVER METABOLISM; MALE; NONHUMAN; SKIN IRRITATION; STRATUM CORNEUM; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0030916075     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.20.421     Document Type: Article

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