Modification of reproductive function in the rat by 3-methylcholanthrene

Pharmacological Research

Volumn 35, Issue 2, 1997, Pages 107-111

  Konstandi, Maria ^a   Pappas, Perikles ^a   Johnson, Elizabeth ^a   Lecklin, Anne ^b   Karageorgou, Maria ^a   Marselos, Marios ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

3 Methylcholanthrene; Conditioned avoidance; Estrus cycle; Rat

Indexed keywords

3 METHYLCHOLANTHRENE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DIESTRUS; ESTRUS CYCLE; FEMALE; MALE; MENSTRUAL IRREGULARITY; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; TESTOSTERONE BLOOD LEVEL;

EID: 0030915833     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1996.0123     Document Type: Article

References (16)

1. Williams GM, Weisburger JH. Chemical carcinogens. Toxicology. 1986;MacMillan, New York.
2. Hornsby PJ, Aldern KA, Harris SE. Methylcholanthrene: a possible pseudosubstrate for adrenocortical 17α Biochem Pharmacol. 35(19):1986;3209-3219.
3. Karageorgou M, Papadimitriou C, Marselos M. Sexual differentiation in the induction of the class 3 aldehyde dehydrogenase. Weiner H. Enzymology and Molecular Biology of Carbonyl Metabolism. 1993;Plenum Press, New York.
4. Newman WC, Moon RC. Anti-uterotrophic response of immature mice to methylcholanthrene. Nature. 221:1969.
5. Romkes M, Piskorska-Pliszczynska J, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats. Toxicol Appl Pharmacol. 87(2):1987;306-314.
6. Romkes M, Safe S. Comparative activities of 2,3,7,8-tetrachloro-dibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus. Toxicol Appl Pharmacol. 92:1988;368-380.
7. Toft DO, Spelsberg TC. A distinction between 3-methylcholanthrene and estrogen binding in the uterus. Cancer Res. 32:1972;2743-2746.
8. Kazandjian A, Spyraki C, Papadopoulou Z, Sfikakis A, Varonos DD. Behavioral and biochemical effects of haloperidol during the estrus cycle of the rat. Neuropharmacology. 27(1):1988;73-78.
9. Sfikakis A, Spyraki C, Sitaras N, Varonos DD. Implication of the estrus cycle on conditioned avoidance behavior in the rat. Physiol Behav. 21:1978;441-446.
10. Ebright RH, Wong JR, Chen LB. Binding of 2-hydroxybenzo(a)-pyrene to estrogen receptors in rat cytosol. Cancer Res. 6:1986;2349-2351.
11. Kleeman JM, Moore RW, Peterson RE. Inhibition of testicular steroidogenesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats: evidence that the key lesion occurs prior to or during pregnenolone formation. Toxicol Appl Pharmacol. 106:1990;112-125.
12. Hruska RE, Olson JR. Species differences in estrogen receptors and in the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Lett. 48:1989;289-299.
13. Umbreit TH, Scala PL, MacKenzie SA, Gallo MA. Alteration of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) by estradiol and tamoxifen. Toxicology. 59:1989;163-169.
14. Nequin LG, Alvarez J, Schwartz NB. Measurement of serum steroid and gonadotropin levels and uterine and ovarian variables throughout 4 day and 5 day estrus cycles in the rat. Biol Rep. 20:1979;659-670.
15. Umbreit TH, Gallo MA. Physiological implications of estrogen receptor modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology. 42:1989;5-14.
16. Pelkonen O, Pasanen M, Vahakangas K. Metabolic activation by the foetus and placenta. Bedford DJ, Bridges JW, Gibson GG. Drug Metabolism from Molecules to Man. 1987;Taylon & Francis, London.