Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABA(A) receptors

European Journal of Medicinal Chemistry

Volumn 32, Issue 4, 1997, Pages 357-363

  Brehm, L ^a   Ebert, B ^a   Kristiansen, U ^a   Wafford, K A ^b   Kemp, J A ^b   Krogsgaard Larsen, P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Cellular electrophysiology; GABA(A) antagonists; GABA(A) partial agonists; GABA(A) receptors; Heterocyclic carboxyl bioisosteres; Molecular pharmacology; Receptor subunits; Recombinant receptors; Structure activity studies; X ray crystallography

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 4,5,6,7 TETRAHYDROISOXAZOLO[4,5 C]PYRIDIN 3 OL; PARTIAL AGONIST; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ELECTROPHYSIOLOGY; GENE EXPRESSION; GRANULE CELL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NONHUMAN; OOCYTE; RAT; SPINAL CORD; TISSUE SPECIFICITY; X RAY CRYSTALLOGRAPHY; XENOPUS;

EID: 0030915294     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(97)89089-7     Document Type: Article

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