Synthesis and cytotoxic action of 3,5-isoxazolidinediones and 2-isoxazolin-5-ones in murine and human tumors

Archiv der Pharmazie

Volumn 330, Issue 3, 1997, Pages 67-73

  Hall, Iris H ^a   Izydore, Robert A ^b   Zhou, Xaioming ^b   Daniels, Dwayne L ^b   Woodard, Tyrone ^b   Debnath, Manik L ^b   Tse, Elaine ^a   Muhammad, Rosallah A ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

anti neoplastic agents; isoxazolidinediones; L1210 leukemic inhibitors; purine synthesis inhibitors

Indexed keywords

2 ISOXAZOLINE DERIVATIVE; 4,4 DIETHYL 2 (4 METHOXYBENZOYL) 3,5 ISOXAZOLIDINEDIONE; ANTINEOPLASTIC AGENT; CYTARABINE; DACTINOMYCIN; ETOPOSIDE; FLUOROURACIL; HYDROXYUREA; ISOXAZOLE DERIVATIVE; MERCAPTOPURINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; DOSE RESPONSE; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; FEMALE; HUMANS; ISOXAZOLES; MICE; MOLECULAR STRUCTURE; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; TUMOR CELLS, CULTURED;

EID: 0030915162     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19973300306     Document Type: Article

References (39)

1. I.H. Hall, R.A. Izydore, T.S. Vital, S.Y. Chen, M.C. Miller MC III, J.A. Bernal-Ramirez, W.A. Okwisa, Anticancer Res. 1995, 15, 199-204.
2. I.H. Hall, O.T. Wong, R. Simlot, M.C. Miller III, R.A. Izydodre, Anticancer Res. 1992, 12, 1355-1362.
3. R.A. Izydore, J.A. Bernal-Ramirez, W.A. Okwisa, L.V. Yarborough, O.T. Wong, I.H. Hall, Pharmazie 1993, 48, 111-117.
4. R. Simlot, R.A. Izydore, O.T. Wong, I.H. Hall, J. Pharm. Sci. 1993, 82, 408-115.
5. R. Simlot, R.A. Izydore, O.T., Wong, I.H. Hall, J. Pharm. Sci. 1994, 83, 367-371.
6. T. Woodard, M.L. Debnath, R. Simlot, R.A. Izydore, D.L. Daniels, O.T. Wong, H. ElSourady, I. H. Hall, Pharm. Res. 1995, 12, 24-38.
7. I.H. Hall, R. Simlot, R.A. Izydore, Arch Pharm. (Weinheim) 1995, 328, 5-10.
8. I.H. Hall, R.a. Izydore, R. Simlot, O.T. Wong, Experientia 1992, 48, 383-386.
9. R. Zinner, R. Moll, Arch. Pharm. (Weinheim) 1966, 299, 562-568.
10. R.A. Izydore, J.A. Bernal-Ramirez, P. Singh, J Org. Chem. 1990, 55, 3761-3767.
11. R.A. Izydore, A.A. Ribciro, I.H. Hall, J. Org. Chem. 1996, 61, 3733-3737.
12. 3) δ 8.9, 28.2, 53.0, 174.4, 175.3.
13. A.C. Konaji, R.D. Hosangadi, Indian J. Chem. 1979 17B, 275-276.
14. R.J. Geran, N.H. Greenburg, M.M. MacDonald, A.M. Schumacher, B.J. Abbott, Cancer Chemo. Rep. 1972, 3, 9-11.
15. A.L. Leibovitz, J.C. Stinson, W.B. McComb III, C.E. McCoy, K.C. Mazur, N.D. Mabry, Cancer Res. 1976, 36, 4562-4569.
16. L.L. Liao, S.M. Kupchan, S.B. Horwitz, Mol. Pharmacol. 1976, 12, 167-3989.
17. E. Cadman, R. Heimer, C. Benz, J. Biol. Chem. 1981, 256, 1695-1704.
18. R.I. Christopherson, M.L. Yu, M.E. Jones, Anal. Biochem. 1981, 11, 240-249.
19. D.C. Eichler, P.A. Fisher, D. Korn, J. Biol. Chem. 1977, 252, 4011-4014.
20. P.P. Mamaril, A. Dobrjasky, S. Green, Cancer Res. 1970, 30, 352-356.
21. H. Sawada, K. Tatsumi, M. Sadada, S. Shirakawa, T. Nakamura, G. Wakisaka, Cancer Res. 1974, 34, 3341-3345.
22. K.M. Anderson, I.S. Mendelson, G. Guzik, Biochem. Biophys. Acta 1975, 383, 56-66.
23. I.H. Hall, G.L. Carlson, G.S Abernathy, C. Piantadosi, J. Med. Chem. 1974, 17, 1253-1257.
24. B.C. Moore, R.B. Hurlbert, J. Biol. Chem. 1966, 241, 4802-4809.
25. F. Maley, S. Ochoa, J. Biol. Chem. 1958, 233, 1538-1543.
26. M.K. Spassova, G.C. Russev, E.V. Goovinsky, Biochem. Pharmacol. 1976, 25, 923-924.
27. J.H. Becker, G.W. Lohr, Klin. Wochenschr. 1979, 57, 1109-1115.
28. S.M. Kalman, P.H. Duffield, T.J. Brzozwki, J. Biol. Chem. 1966, 241, 1871-1877.
29. R.M. Archibald, J. Biol. Chem. 1944, 156, 121-142.
30. S.B. Koritz, P.P. Gohen. J. Biol. Chem. 1954, 209, 145-150.
31. A. Kampf, R.L. Barfknecht, P.J. Schaffer, S. Osaki, M.P. Mertes, J. Med. Chem. 1976, 19, 903-908.
32. Y.K. Ho, T. Hakala, S.F. Zakrzewski, Cancer Res. 1971, 32, 1023-1028.
33. O.H. Lowry, J. Rosebrough, A.L. Farr, R.J. Randall, J. Biol. Chem. 1951, 193, 265-275.
34. A.S. Bagnara, L.R. Finch, Anal. Biochem. 1971, 45, 24-34.
35. D. Hunting, J.F. Henderson, Can. J. Biochem. 1982, 59, 723-727.
36. H. Suzuki, T. Nishimura, S.K. Muto, N. Tanaka, J. Antibacterial. 1978, 32, 875-883.
37. J.F. Pera, Sr, C.J. Rawlings, J. Shackleton, J.J. Roberts, Biochem. Biophy. Acta 1981, 655, 152-166.
38. J.W. Woynarowski, T.A. Beerman, J. Konopa, Biochem. Pharmacol. 1981, 30, 3005-3007.
39. Y. Zhao, I.H. Hall, C.B. Oswald, T. Yokoi, K.H. Lee, Chem. Phar. Bull. 1987, 35, 2052-2061.