Comparative study of DNA adduct formation in mice following inhalation of smoke from cigarettes that burn or primarily heat tobacco

Environmental and Molecular Mutagenesis

Volumn 29, Issue 3, 1997, Pages 303-311

  Brown, Buddy G ^a,b   Lee, Chin K ^a   Bombick, Betsy R ^a   Ayres, Paul H ^a   Mosberg, Arnold T ^a   Doolittle, David J ^a  

^a R J REYNOLDS TOBACCO COMPANY   (United States)

^b RJ Reynolds Tobacco Co   (United States)

Author keywords

Cigarette smoke; DNA adducts; Micronuclei

Indexed keywords

CIGARETTE SMOKE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; FEMALE; GENOTOXICITY; HEART; INHALATION; LUNG; MALE; MICRONUCLEUS; MOUSE; NONHUMAN;

ANIMALS; DNA ADDUCTS; HEART; LUNG; MALE; MICE; MICRONUCLEUS TESTS; MUTAGENS; MYOCARDIUM; PLANTS, TOXIC; SMOKE; TOBACCO;

EID: 0030914737     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1997)29:3<303::AID-EM11>3.0.CO;2-I     Document Type: Article

References (38)

1. Ayres PH, Mosberg AT, Coggins CRE (1990): Modernization of nose-only smoking machines for use in animal inhalation studies. J Am Coll Toxicol 9:441-446.
2. Ayres PH, Higuchi MA, Sagartz JW, Mosherg AT, Burger GT (1995): Subchronic inhalation study of mainstream smoke from a new prototype cigarette. Abstracts of the VII International Congress of Toxicology Int Toxicol 7:20-P-17.
3. Balansky RM, Blagoeva PM, Mircheva ZI (1987): Investigation of the mutagenic activity of tobacco smoke. Mutai Res 188:13-19.
4. Basler A (1982): SCEs in lymphocytes of rats after exposure in vivo to cigarette smoke or to cyclophosphamide. Mutat Res 102:137-143.
5. Benedict WF, Banerjee A, Kangalingam KK, Dansie DR, Kouri RE, Henry CJ (1984): Increased sister-chromatid exchange in bone-marrow cells of mice exposed to whole cigarette smoke. Mutat Res 136:73-80.
6. Bombick BR, Murli H, Citone M, Avalos J, Putnam K, Bombick D, Morgan W, Doolittle DJ (1995): Comparative studies on the genotoxic potential of mainstream smoke condensate from cigarettes which burn or primarily heat tobacco. Abstracts of the VII International Congress of Toxicology Int Toxicol 7:46-P-15.
7. Bombick DW, Putnam K, Bombick BR, Morgan WT, Ayres PH, Doolittle DJ (1995): In vitro assessment of biological activity of mainstream smoke from cigarettes which burn or primarily heat tobacco. Abstracts of the VII International Congress of Toxicology Int Toxicol 7:73-P-19.
8. Bond JA, Wolff RK, Harkema JR, Mauderly JL, Henderson RF, Griffith WC, McClellan RO (1988): Distribution of DNA adducts in the respiratory tracts of rats exposed to diesel exhaust. Toxicol Appl Pharmacol 96:336-346.
9. Bond JA, Chen BT, Griffith WC, Mauderly JL (1989): Inhaled cigarette smoke induces the formation of DNA adducts in lungs of rats. Toxicol Appl Pharmacol 99:161-172.
10. Borgerding MF, Blakely RL, Winkler LS, Henry DD, Bowman J, Smith DH (1995): Methodology for the quantitative determination of free radicals in mainstream vapor phase cigarette smoke. Abstract 58. Forty-ninth Tobacco Chemists' Research Conference, September 24-27, 1995, Lexington, KY, USA.
11. Borgerding MF, Bodnar JA, Chung HL, Mangan PP, Morrison CC, Risner CH, Rogers JC, Simmons DF, Uhrig MS, Wendelboe FN, Wingate DE, Winkler LS (1996): Chemical and biological studies of a new cigarette which primarily heats tobacco. Part I. Chemical composition of mainstream smoke. Food Chem Toxicol (in press).
12. Brown BG, Bombick BR, McKarns SC, Lee CK, Ayres PH, Doolittle DJ (1995): Molecular toxicology endpoints in rodent inhalation studies. Exp Toxicol Pathol 47:183-191.
13. Coggins CRE, Doolittle DJ, Lee CK, Ayres PH, Mosberg AT, Bolin DC, Burger GT, Hayes AW (1990): Histopathology, urine mutagenicity, and bone marrow cytogenetics of mice exposed nose-only to smoke from cigarettes that burn or heat tobacco. Inhal Toxicol 2:407-431.
14. Cuzick J, Routledge MN, Jenkins D, Garner RC (1990): DNA adducts in different tissues of smokers and non-smokers. Int J Cancer 45:673-678.
15. Doolittle DJ, Lee CK, Ivett JL, Mirsalis JC, Riccio E, Rudd CJ, Burger GT, Hayes AW (1990a): Comparative studies on the genotoxic activity of mainstream smoke condensate from cigarettes which burn or only heat tobacco. Environ Mol Mutagen 15:93-105.
16. Doolittle DJ, Rahn CA, Riccio E, Passananti GT, Howard G, Vesell ES, Burger GT, Hayes AW (1990b): Comparative studies of the mutagenicity of urine from smokers and non-smokers on a controlled non-mutagenic diet. Food Chem Toxicol 9:639-646.
17. Gairola CG, Gupta RC (1991): Cigarette smoke-induced DNA adducts in the respiratory and nonrespiratory tissues of rats. Environ Mol Mutagen 17:253-257.
18. Gupta RC, Sopori ML, Gairola CG (1989): Formation of cigarette smoke-induced DNA adducts in the rat lung and nasal mucosa. Cancer Res 49:1916-1920.
19. Korte A, Wagner HM, Obe G (1981): Simultaneous exposure of Chinese hamsters to ethanol and cigarette smoke, cytogenetic aspects. Toxicology 20:237-246.
20. Lee CK, Brown BG, Reed EA, Lowe GD, McKarns SC, Fulp CW, Coggins CRE, Ayres PH, Doolittle DJ (1990): Analysis of cytogenetic effects in bone-marrow cells of rats subchronically exposed to smoke from cigarettes which burn or only heat tobacco. Mutat Res 240:251-257.
21. Lee CK, Brown BG, Reed EA, Rahn CA, Coggins CRE, Doolittle DJ, Hayes AW (1992a): Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette. II. DNA adducts and alveolar macrophage cytogenetics. Fundam Appl Toxicol 19:141-146.
22. Lee CK, Brown BG, Reed EA, Hejtmancik M, Mosberg AT, Doolittle DJ, Hayes AW (1992b): DNA adduct formation in mice following dermal application of smoke condensates from cigarettes that burn or heat tobacco. Environ Mol Mutagen 20:313-319.
23. Lee CK, Brown BG, Reed EA, Coggins CRE, Doolittle DJ, Hayes AW (1993): Ninety-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette: DNA adducts and alveolar macrophage cytogenetics. Fundam Appl Toxicol 20:393-401.
24. 32P-postlabeling assay of DNA adducts. Anal Biochem 227:156-161.
25. Lee CK, Brown BG, Bombick BR, Ayres PH, Mosberg AT, Doolittle DJ (1995b): In vivo genetic toxicology studies of mainstream smoke from a new cigarette which primarily heats tobacco. Abstracts of the VII International Congress of Toxicology. Int Toxicol 7:46-P-6.
26. McKarns SC, Doolittle DJ (1995): Comparative studies of mainstream cigarette smoke condensate from cigarettes which burn or primarily heat tobacco in the intercellular communication assay. Abstracts of the VII International Congress of Toxicology. Int Toxicol 7:84-P-26.
27. Mizusaki S, Okamoto H, Akiyama A, Fukuhara Y (1977): Relationship between chemical constituents of tobacco and mutagenic activity of cigarette smoke condensate. Mutat Res 48:319-326.
28. Odagiri Y (1988): Detection of cytogenetic effects of air pollutants by the micronucleus test. Taiki Osen Gakkaishi 23(2):92-102.
29. Phillips DH, Hewer A, Martin CN (1988): Correlation of DNA adduct levels in human lung with cigarette smoking. Nature 336:790-792.
30. Phillips DH, Schoket B, Hewer A (1990): Influence of cigarette smoking on the levels of DNA adducts in human bronchial epithelium and white blood cells. Int J Cancer 46:569-575.
31. Putnam DL, David RM, Melhorn JM, Dansie DR, Stone CJ, Henry CJ (1985): Dose-responsive increase in sister-chromatid exchanges in bone-marrow cells of mice exposed nose-only to whole cigarette smoke. Mutat Res 156:181-186.
32. 32P-analysis of cigarette smoke-induced DNA damage in human tissues and mouse skin. Cancer Res 46:5869-5877.
33. Randerath E, Mittal D, Randerath K (1988): Tissue distribution of covalent DNA damage in mice treated dermally with cigarette "tar": Preference for lung and heart DNA. Carcinogenesis 9:75-80.
34. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7:1543-1551.
35. Reed BA, Lee CK, Brown BG, Coggins CRE, Hayes AW, Doolittle DJ (1994): Cytogenetic studies in laboratory animals exposed by inhalation to mainstream smoke or environmental tobacco smoke. In Obe G, Natarajan AT (eds): "Chromosomal Alterations: Origin and Significance." Berlin: Springer-Verlag, pp 362-379.
36. Schmid W (1975): The micronucleus test. Mutat Res 31:9-15.
37. Smith CJ, McKarns SC, Davis RA, Livingston SD, Bombick BR, Avalos JT, Morgan WT, Doolittle DJ (1996): Human urine mutagenicity study comparing cigarettes which burn or primarily heat tobacco. Mutat Res 361:1-9.
38. Steele RH, Payne VM, Fulp CW, Rees DC, Lee CK, Doolittle DJ (1995): A comparison of the mutagenicity of mainstream cigarette smoke condensates from a representative sample of the U.S. cigarette market with a Kentucky reference cigarette (1R4F). Mutat Res 342:179-190.