메뉴 건너뛰기




Volumn 65, Issue 6, 1997, Pages 2313-2320

Clostridium perfringens urease genes are plasmid borne

Author keywords

[No Author keywords available]

Indexed keywords

UREASE;

EID: 0030914437     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.6.2313-2320.1997     Document Type: Article
Times cited : (30)

References (52)
  • 3
    • 0026067217 scopus 로고
    • Identification of genes and gene products whose expression is activated during nitrogen-limited growth in Bucillus subtills
    • Atkinson, M. R., und S. H. Fisher. 1991. Identification of genes and gene products whose expression is activated during nitrogen-limited growth in Bucillus subtills. J. Bactcriol. 173:23-27.
    • (1991) J. Bactcriol. , vol.173 , pp. 23-27
    • Atkinson, M.R.1    Fisher, S.H.2
  • 4
    • 0017551429 scopus 로고
    • Characterization and transferability of Clostridium perfringens plasmids
    • Bréfort, G., M. Magot, H. Ionesco, und M. Sebald. 1977. Characterization and transferability of Clostridium perfringens plasmids. Plasmid 1:52-66.
    • (1977) Plasmid , vol.1 , pp. 52-66
    • Bréfort, G.1    Magot, M.2    Ionesco, H.3    Sebald, M.4
  • 5
    • 0040057284 scopus 로고
    • Genome organization of the anaerobic pathogen Clostridium perfringens
    • Canard, B., und S. T. Cole. 1989. Genome organization of the anaerobic pathogen Clostridium perfringens. Proc. Natl. Acad. Sci. USA 86:6676-6680.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 6676-6680
    • Canard, B.1    Cole, S.T.2
  • 6
    • 0026773588 scopus 로고
    • Genomic diversity and organisation of virulence genes in the pathogenic anaerobe Clostridium perfringens
    • Canard, B., B. Saint-Joanis, and S. T. Cole. 1992. Genomic diversity and organisation of virulence genes in the pathogenic anaerobe Clostridium perfringens. Mol. Microbiol. 6:1421-1429.
    • (1992) Mol. Microbiol. , vol.6 , pp. 1421-1429
    • Canard, B.1    Saint-Joanis, B.2    Cole, S.T.3
  • 7
    • 0029591917 scopus 로고
    • Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease. a potentially critical determinant of host-pathogen interaction
    • Clemens, D. L., B.-Y. Lee, and M. A. Horwitz. 1995. Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease. a potentially critical determinant of host-pathogen interaction. J. Bacteriol. 177:5644-5652.
    • (1995) J. Bacteriol. , vol.177 , pp. 5644-5652
    • Clemens, D.L.1    Lee, B.-Y.2    Horwitz, M.A.3
  • 8
    • 0027464964 scopus 로고
    • Identification of a nitrogen-regulated promoter controlling expression of Klebsiella pneumoniae urease genes
    • Collins, C. M., D. M. Gutman, and H. Laman. 1993. Identification of a nitrogen-regulated promoter controlling expression of Klebsiella pneumoniae urease genes. Mol. Microbiol. 8:187-198.
    • (1993) Mol. Microbiol. , vol.8 , pp. 187-198
    • Collins, C.M.1    Gutman, D.M.2    Laman, H.3
  • 9
  • 10
    • 0026723973 scopus 로고
    • Expression of Hleicobacter pylori urease genes in Escherichia coli grown under nitrogen-limiting conditions
    • Cussac, V., R. L. Ferrero, and A. Labigne. 1992. Expression of Hleicobacter pylori urease genes in Escherichia coli grown under nitrogen-limiting conditions. J. Bacteriol. 174:2466-2473.
    • (1992) J. Bacteriol. , vol.174 , pp. 2466-2473
    • Cussac, V.1    Ferrero, R.L.2    Labigne, A.3
  • 11
    • 0027164407 scopus 로고
    • Cloning, nucleotide sequencing, and expression of the Clostridium perfringens enterotoxin gene in Escherichia coli
    • Cieciulin, J. R., P. C. Hanna, and B. A. McClane. 1993. Cloning, nucleotide sequencing, and expression of the Clostridium perfringens enterotoxin gene in Escherichia coli. Infect. Immun. 61:3429-3439.
    • (1993) Infect. Immun. , vol.61 , pp. 3429-3439
    • Cieciulin, J.R.1    Hanna, P.C.2    McClane, B.A.3
  • 12
    • 0027937581 scopus 로고
    • Typing of Clostridium perfringens by in vitro amplification of toxin genes
    • Daube, G., B. China, P. Simon, K. Hvala, and J. Mainil. 1994. Typing of Clostridium perfringens by in vitro amplification of toxin genes. J. Appl. Bacteriol. 77:650-655.
    • (1994) J. Appl. Bacteriol. , vol.77 , pp. 650-655
    • Daube, G.1    China, B.2    Simon, P.3    Hvala, K.4    Mainil, J.5
  • 13
    • 0027246554 scopus 로고
    • IS1151, an IS-like element of Clostridium perfringens
    • Daube, G., P. Simon, and A. Kaeckenbeeck. 1993. IS1151, an IS-like element of Clostridium perfringens. Nucleic Acids Res. 21:352.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 352
    • Daube, G.1    Simon, P.2    Kaeckenbeeck, A.3
  • 14
    • 0030122271 scopus 로고    scopus 로고
    • Hybridization of 2,659 Clostridium perfringens isolates with gene probes for seven toxins (α, β, ∈, ι, ο, μ., and enterotoxin) and for sialidase
    • Daube, G., P. Simon, B. Limbourg, C. Manteca, J. Mainil, and A. Kaeckenbeeck. 1997. Hybridization of 2,659 Clostridium perfringens isolates with gene probes for seven toxins (α, β, ∈, ι, ο, μ., and enterotoxin) and for sialidase. Am. J. Vet. Res. 57:496-501.
    • (1997) Am. J. Vet. Res. , vol.57 , pp. 496-501
    • Daube, G.1    Simon, P.2    Limbourg, B.3    Manteca, C.4    Mainil, J.5    Kaeckenbeeck, A.6
  • 15
    • 0028902206 scopus 로고
    • UreR activates transcription at multiple promoters within the plasmid-encoded urease locus of the Enter-obacteriaceac
    • D'Orazio, S. E., and C. M. Collins. 1995. UreR activates transcription at multiple promoters within the plasmid-encoded urease locus of the Enter-obacteriaceac. Mol. Microbiol. 16:145-155.
    • (1995) Mol. Microbiol. , vol.16 , pp. 145-155
    • D'Orazio, S.E.1    Collins, C.M.2
  • 16
    • 0027474146 scopus 로고
    • Characterization of a plasmid-encoded urease gene cluster found among members of the family Enterobacteriaceae
    • D'Orazio, S. E. F., and C. M. Collins. 1993. Characterization of a plasmid-encoded urease gene cluster found among members of the family Enterobacteriaceae. J. Bacteriol. 175:1860-1864.
    • (1993) J. Bacteriol. , vol.175 , pp. 1860-1864
    • D'Orazio, S.E.F.1    Collins, C.M.2
  • 17
    • 0027191825 scopus 로고
    • The plasmid-encoded urease gene cluster of the Enterobactertaceae is positively regulated by UreR, a member of the AraC family of transcriptional activators
    • D'Orazio, S. E. F., and C. M. Collins. 1993. The plasmid-encoded urease gene cluster of the Enterobactertaceae is positively regulated by UreR, a member of the AraC family of transcriptional activators. J. Bacteriol. 175:3459-3467.
    • (1993) J. Bacteriol. , vol.175 , pp. 3459-3467
    • D'Orazio, S.E.F.1    Collins, C.M.2
  • 18
    • 0025823864 scopus 로고
    • Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets
    • Eaton, K. A., C. L. Brooks, D. R. Morgan, and S. Krakowka. 1991. Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect. Immun. 59:2470-2475.
    • (1991) Infect. Immun. , vol.59 , pp. 2470-2475
    • Eaton, K.A.1    Brooks, C.L.2    Morgan, D.R.3    Krakowka, S.4
  • 19
    • 0000122573 scopus 로고
    • PHYLIP - Phylogeny inference package (version 3.2)
    • Felsenstein, J. 1989. PHYLIP - phylogeny inference package (version 3.2). Cladistics 5:164-166.
    • (1989) Cladistics , vol.5 , pp. 164-166
    • Felsenstein, J.1
  • 20
    • 0000522135 scopus 로고
    • The importance of urease in acid protection for the gastric-colonizing bacteria Helicobacter pylori and Helicobacter felis sp. nov
    • Ferrera, R. L., and A. Lee. 1991. The importance of urease in acid protection for the gastric-colonizing bacteria Helicobacter pylori and Helicobacter felis sp. nov. Microb. Ecol. Health Dis. 4:121-134.
    • (1991) Microb. Ecol. Health Dis. , vol.4 , pp. 121-134
    • Ferrera, R.L.1    Lee, A.2
  • 21
    • 0022873043 scopus 로고
    • Characterization of a bacteriocinogenic plasmid from Clostridium perfringens and molecular genetic analysis of the bacteriocin-encoding gene
    • Garnier, T., and S. T. Cole. 1986. Characterization of a bacteriocinogenic plasmid from Clostridium perfringens and molecular genetic analysis of the bacteriocin-encoding gene. J. Bacteriol. 168:1189-1196.
    • (1986) J. Bacteriol. , vol.168 , pp. 1189-1196
    • Garnier, T.1    Cole, S.T.2
  • 22
    • 0023682818 scopus 로고
    • Complete nucleotide sequence and genetic organization of the bacteriocinogenic plusmid pIP404 from Clostridium perfringens
    • Garnier, T., and S. T. Cole. 1988. Complete nucleotide sequence and genetic organization of the bacteriocinogenic plusmid pIP404 from Clostridium perfringens. Plasmid 19:134-150.
    • (1988) Plasmid , vol.19 , pp. 134-150
    • Garnier, T.1    Cole, S.T.2
  • 23
    • 0000925040 scopus 로고
    • Colony hybridization: A method for the isolation of cloned DNAs that contain a specific gene
    • Grunstein, M., and D. Hogness. 1975. Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. Proc. Natl. Acad. Sci. USA 72:3961-3965.
    • (1975) Proc. Natl. Acad. Sci. USA , vol.72 , pp. 3961-3965
    • Grunstein, M.1    Hogness, D.2
  • 24
    • 0020959710 scopus 로고
    • Studies on transformation in Escherichia coli with plasmids
    • Hanahan, D. 1983. Studies on transformation in Escherichia coli with plasmids. J. Mol. Biol. 166:557-580.
    • (1983) J. Mol. Biol. , vol.166 , pp. 557-580
    • Hanahan, D.1
  • 26
    • 0026605537 scopus 로고
    • CLUSTAL V: Improved software for multiple sequence alignment
    • Higgins, D. H., A. J. Bleasby, and R. Fush. 1992. CLUSTAL V: improved software for multiple sequence alignment. CARIOS 8:189-191.
    • (1992) CARIOS , vol.8 , pp. 189-191
    • Higgins, D.H.1    Bleasby, A.J.2    Fush, R.3
  • 27
    • 0025299364 scopus 로고
    • Morganella morganii urease: Purification, characterization, and isolation of gene sequences
    • Hu, L. T., E. B. Nicholson, B. D. Jones, M. J. Lynch, and H. L. T. Mobley. 1990. Morganella morganii urease: purification, characterization, and isolation of gene sequences. J. Bacteriol. 172:3073-3080.
    • (1990) J. Bacteriol. , vol.172 , pp. 3073-3080
    • Hu, L.T.1    Nicholson, E.B.2    Jones, B.D.3    Lynch, M.J.4    Mobley, H.L.T.5
  • 28
    • 0026542943 scopus 로고
    • Cloning and nucleotide sequence analysis of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli
    • Hunter, S. E. C., I. N. Clarke, D. C. Kelly, and R. W. Titball. 1992. Cloning and nucleotide sequence analysis of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli. Infect. Immun. 60:102-110.
    • (1992) Infect. Immun. , vol.60 , pp. 102-110
    • Hunter, S.E.C.1    Clarke, I.N.2    Kelly, D.C.3    Titball, R.W.4
  • 29
    • 0029647957 scopus 로고
    • The crystal structure of ureasc from Klebsiella aerogenes
    • Jabri, E., M. B. Carr, R. P. Hausinger, and P. A. Karplus. 1995. The crystal structure of ureasc from Klebsiella aerogenes. Science 268:998-1004.
    • (1995) Science , vol.268 , pp. 998-1004
    • Jabri, E.1    Carr, M.B.2    Hausinger, R.P.3    Karplus, P.A.4
  • 30
    • 0025220411 scopus 로고
    • Construction of a urease-negativc mutant of Proteus mirabilis: Analysis of virulence in a mouse model of ascending urinary tract infection
    • J. Jones, B. D., C. V. Lockatell, D. E. Johnson, J. W. Warren, and H. L. T. Mobley. 1990. Construction of a urease-negativc mutant of Proteus mirabilis: analysis of virulence in a mouse model of ascending urinary tract infection. Infect. Immun. 58:1120-1123.
    • (1990) Infect. Immun. , vol.58 , pp. 1120-1123
    • Jones, B.D.1    Lockatell, C.V.2    Johnson, D.E.3    Warren, J.W.4    Mobley, H.L.T.5
  • 31
    • 0029832177 scopus 로고    scopus 로고
    • Genome mapping of Closiridium perfringens strains with I-Ceul shows many virulence genes to he plasmid-borne
    • Katayama, S., B. Dupuy, G. Daube, B. China, and S. T. Cole. 1996. Genome mapping of Closiridium perfringens strains with I-Ceul shows many virulence genes to he plasmid-borne. Mol. Gen. Genet. 251:720-726.
    • (1996) Mol. Gen. Genet. , vol.251 , pp. 720-726
    • Katayama, S.1    Dupuy, B.2    Daube, G.3    China, B.4    Cole, S.T.5
  • 32
    • 0029589673 scopus 로고
    • Rapid expansion of the physical and genetic map of the chromosome of Clostridium perfringens CPN50
    • Katayama, S., B. Dupuy, T. Garnier, and S. T. Cole. 1995. Rapid expansion of the physical and genetic map of the chromosome of Clostridium perfringens CPN50. J. Bucteriol. 177:5680-5685.
    • (1995) J. Bucteriol. , vol.177 , pp. 5680-5685
    • Katayama, S.1    Dupuy, B.2    Garnier, T.3    Cole, S.T.4
  • 33
    • 0018359002 scopus 로고
    • Raffinose increases sporulation and enterotoxin production by Clostridium perfringens type A
    • Labbe, R. G., and D. K. Rey. 1979. Raffinose increases sporulation and enterotoxin production by Clostridium perfringens type A. Appl. Environ. Microbiol. 37:1196-1200.
    • (1979) Appl. Environ. Microbiol. , vol.37 , pp. 1196-1200
    • Labbe, R.G.1    Rey, D.K.2
  • 34
    • 0025979283 scopus 로고
    • Shuttle cloning and nucleotide sequences of Helicobacter pylori genes responsible for urease activity
    • Labigne, A., V. Cussac, and P. Courcoux. 1991. Shuttle cloning and nucleotide sequences of Helicobacter pylori genes responsible for urease activity. J. Bacteriol. 173:1920-1931.
    • (1991) J. Bacteriol. , vol.173 , pp. 1920-1931
    • Labigne, A.1    Cussac, V.2    Courcoux, P.3
  • 35
    • 0028225456 scopus 로고
    • Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens
    • Lyristis, M., A. E. Bryant, J. Sloan, M. M. Awad, I. T. Nisbet, D. L. Stevens, and J. I. Rood. 1994. Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens. Mol. Microbiol. 12:761-777.
    • (1994) Mol. Microbiol. , vol.12 , pp. 761-777
    • Lyristis, M.1    Bryant, A.E.2    Sloan, J.3    Awad, M.M.4    Nisbet, I.T.5    Stevens, D.L.6    Rood, J.I.7
  • 36
    • 0028084886 scopus 로고
    • Purification and characterization of a Clostridium perfringens 120-kilodalton collagenase and nucleotide sequence of the corresponding gene
    • Matsushita, O., K. Yoshihara, S. Katayama, J. Minami, and A. Okabe. 1994. Purification and characterization of a Clostridium perfringens 120-kilodalton collagenase and nucleotide sequence of the corresponding gene. J. Bacteriol. 176:149-156.
    • (1994) J. Bacteriol. , vol.176 , pp. 149-156
    • Matsushita, O.1    Yoshihara, K.2    Katayama, S.3    Minami, J.4    Okabe, A.5
  • 38
    • 0001875691 scopus 로고
    • Toxins of Clostridiuin perfringens types A, B, C, D and E
    • F. Dorner and J. Drews (ed.). Pergamon Press, Oxford
    • McDonel, J. L. l986. Toxins of Clostridiuin perfringens types A, B, C, D and E. p. 477-517. In F. Dorner and J. Drews (ed.), Pharmacology of bacterial toxins. Pergamon Press, Oxford.
    • (1986) Pharmacology of Bacterial Toxins , pp. 477-517
    • McDonel, J.L.1
  • 39
    • 0027998260 scopus 로고
    • Expression from the Clostridium perfringens cpe promoter in C. perfringens and Bacillus subtilis
    • Melville, S. B., R. Labbe, and A. L. Sonenshein. 1994. Expression from the Clostridium perfringens cpe promoter in C. perfringens and Bacillus subtilis. Infect. Immun. 62:5550-5558.
    • (1994) Infect. Immun. , vol.62 , pp. 5550-5558
    • Melville, S.B.1    Labbe, R.2    Sonenshein, A.L.3
  • 40
    • 0028351303 scopus 로고
    • A 4.6 kb DNA region of Rhizobium meliloti involved in determining urease hydrogenase activities carries the structural genes for urease (ureA, ureB. urcC) interrupted by other rending frames
    • Miksch, G., W. Arnold, P. Lettzch, U. B. Priefor, and A. Pühler. 1994. A 4.6 kb DNA region of Rhizobium meliloti involved in determining urease and hydrogenase activities carries the structural genes for urease (ureA, ureB. urcC) interrupted by other rending frames. Mol. Gen. Genet. 242:539-550.
    • (1994) Mol. Gen. Genet. , vol.242 , pp. 539-550
    • Miksch, G.1    Arnold, W.2    Lettzch, P.3    Priefor, U.B.4    Pühler, A.5
  • 41
    • 0024514293 scopus 로고
    • Microbial ureases: Significance. regulation. and molecular characterization
    • Mobley, H. L., and R. P. Hausinger. 1989. Microbial ureases: significance. regulation. and molecular characterization. Microbiol. Rev. 53:85-108.
    • (1989) Microbiol. Rev. , vol.53 , pp. 85-108
    • Mobley, H.L.1    Hausinger, R.P.2
  • 43
    • 0001305277 scopus 로고
    • Amplification of flanking sequences by inverse PCR
    • M. A. Innis, D. H. Gelford, J. J. Sninsky, and T. J. White (ed.). Academic Press, Inc., Los Angeles, Calif.
    • Ochman, H., M. M. Medhoru, D. Garza, and D. L. Hartl. 1990. Amplification of flanking sequences by inverse PCR. p. 219-227. In M. A. Innis, D. H. Gelford, J. J. Sninsky, and T. J. White (ed.), PCR protocols: a guide to methods and applications. Academic Press, Inc., Los Angeles, Calif.
    • (1990) PCR Protocols: A Guide to Methods and Applications , pp. 219-227
    • Ochman, H.1    Medhoru, M.M.2    Garza, D.3    Hartl, D.L.4
  • 44
    • 0027365422 scopus 로고
    • Characterization of Clostridium perfringens iota-toxin genes and expression in Escherichia coli
    • Perelle, S., M. Gibert, P. Roquet, and M. R. Popoff. 1493. Characterization of Clostridium perfringens iota-toxin genes and expression in Escherichia coli. Infect Immun. 61:5147-5156.
    • (1493) Infect Immun. , vol.61 , pp. 5147-5156
    • Perelle, S.1    Gibert, M.2    Roquet, P.3    Popoff, M.R.4
  • 45
    • 0022395747 scopus 로고
    • Correlative properties for a differentiation of two Clostridium sordelli phenotypes and their distinction from Clostridium bifermentans
    • Roggentin, P., G. G. Gutschker, R. Schauer, and R. Hohrecht. 1985. Correlative properties for a differentiation of two Clostridium sordelli phenotypes and their distinction from Clostridium bifermentans. Zentralbl. Bakteriol. Mikrobiol. Hyg. Ser. A 260:319-328.
    • (1985) Zentralbl. Bakteriol. Mikrobiol. Hyg. Ser. A , vol.260 , pp. 319-328
    • Roggentin, P.1    Gutschker, G.G.2    Schauer, R.3    Hohrecht, R.4
  • 46
    • 0025824660 scopus 로고
    • Molecular genetics and pathogenesis of Clostridium perfrigens
    • Rood, J. I., and S. T. Cole. 1991. Molecular genetics and pathogenesis of Clostridium perfrigens Microbiol. Rev. 55:621-648.
    • (1991) Microbiol. Rev. , vol.55 , pp. 621-648
    • Rood, J.I.1    Cole, S.T.2
  • 48
    • 0016441787 scopus 로고
    • Minimal growth requirements for Clostridium perfrigens and isolation of auxotrophic mutants
    • Sebald, M., and R. N. Costilow. 1975. Minimal growth requirements for Clostridium perfrigens and isolation of auxotrophic mutants. App. Microbiol. 29:1-6.
    • (1975) App. Microbiol. , vol.29 , pp. 1-6
    • Sebald, M.1    Costilow, R.N.2
  • 49
    • 0028203277 scopus 로고
    • The virR gene. a member of a class of two-component response regulators, regulates the production of pcrfringolysin O. collagenase. and hemagglutinin in Clostridium perfrigens
    • Shimizu, T., W. Ba-Thein, M. Tamaki, and H. Hayashi. 1994. The virR gene. a member of a class of two-component response regulators, regulates the production of pcrfringolysin O. collagenase. and hemagglutinin in Clostridium perfrigens J. Bacteriol, 176:1616-1623.
    • (1994) J. Bacteriol , vol.176 , pp. 1616-1623
    • Shimizu, T.1    Ba-Thein, W.2    Tamaki, M.3    Hayashi, H.4
  • 50
    • 0025713535 scopus 로고
    • Testing strains of Clostridium perfringens type A isolated from diarrhoeic pigs for the presence of the enterotoxin gene
    • van Damme-Jongsten, M., J. Rodhouse, R. Gilbert, and S. Notermans. 1990. Testing strains of Clostridium perfringens type A isolated from diarrhoeic pigs for the presence of the enterotoxin gene. Vet. Rec. 126:191-192.
    • (1990) Vet. Rec. , vol.126 , pp. 191-192
    • Van Damme-Jongsten, M.1    Rodhouse, J.2    Gilbert, R.3    Notermans, S.4
  • 51
    • 0024354276 scopus 로고
    • Cloning and sequencing of the Clostridium perfringens enterotoxin gene
    • van Damme-Jongsten, M., K. Wernars, and S. Notermans. 1989. Cloning and sequencing of the Clostridium perfringens enterotoxin gene. Antonie van Leuwenhoek 56:181-190.
    • (1989) Antonie Van Leuwenhoek , vol.56 , pp. 181-190
    • Van Damme-Jongsten, M.1    Wernars, K.2    Notermans, S.3
  • 52
    • 0021943518 scopus 로고
    • Improved M13 phage cloning vectors and host strains: Nucleotide sequences of the M13mp18 and pUC19 vectors
    • Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:113-119.
    • (1985) Gene , vol.33 , pp. 113-119
    • Yanisch-Perron, C.1    Vieira, J.2    Messing, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.