Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured pollard III prostate tumor cells

Journal of Urology

Volumn 158, Issue 1, 1997, Pages 269-274

  Sosnowski, Jacek ^a   Stetter Neel, Caroline ^a   Cole, Dennis ^a   Durham, John P ^a   Mawhinney, Michael G ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Glucocorticoid; Prostate; Protein kinase C; Sphinganine

Indexed keywords

ALDOSTERONE; CALPHOSTIN C; CERAMIDE DERIVATIVE; PHORBOL ESTER; PROTEIN KINASE C INHIBITOR; SEX HORMONE; SPHINGANINE; STEROID HORMONE; TRIAMCINOLONE ACETONIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; GROWTH INHIBITION; HORMONE RESISTANCE; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE TUMOR; RAT;

EID: 0030914232     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005392-199707000-00084     Document Type: Article

References (20)

1. Pollard, M. and Luckert, P. H.: Transplantable metastasing prostate adenocarcinoma in rats. J. Natl. Cancer Inst., 54: 643, 1975.
2. Pugh, T. D., Chang, C., Nemura, H. and Weindrach, R.: Prostatic localization of spontaneous early invasive carcinoma in Lobund-Wistar rats. Cancer Res., 54: 5766, 1994.
3. Chan, S.: Androgen and glucocorticoid receptors in the Pollard prostate adenocarcinoma cell lines. Prostate, 1: 53, 1980.
4. Neubauer, B. L., Best, K. L., Goode, R. L., Heiman, M. L., Hoover, D. M., Robertson, D. W., Sarosdy, M. F., Shaar, C. J., Tanzer, L. R. and Merriman, R. L.: Comparative anti-tumor effects of hormonal ablation, estrogen agonist, estrogen cytotoxic derivative, and anti-estrogen in the PAIII rat prostatic adenocarcinoma. Cancer Res., 52: 4663, 1992.
5. Koutsilieris, M., Grondin, F. and Leboux, J. G.: The expression of m-RNA for glucocorticoid receptor gene and functional glucocorticoid receptors detected in PAIII rat prostate adenocarcinoma cells. Anticancer Res., 12: 899, 1992.
6. Vane, J. and Botting, R.: Inflammation and the mechanism of action of antiinflammation drugs. FASEB J., 1: 89, 1987.
7. Akompong, T., Spencer, R. L. and McEwen, B. S.: Glucocorticoids inhibit soluble phospholipase C activity and cytosolic guanine nucleotide regulatory protein-alpha 1 immunoreactivity in spleen. Endocrinology, 133: 1963, 1993.
8. Hannun, Y. A. and Bell, R. M.: Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science, 243: 500, 1989.
9. Ramachandran, C. K., Murray, D. K. and Nelson, D. H.: Dexamethasone increases neutral sphingomyelinase activity and sphingosine levels in 3T3-L1 fibroblasts. Biochem. Biophys. Res. Comm., 167: 607, 1990.
10. Pfahl, M.: Nuclear receptor/AP-1 interaction. Endocrine Reviews, 14: 651, 1993.
11. Durham, J. P., Butcher, F. R., Teoh, T. S., Miller, R. and Mawhinney, M. G.: Characterization and androgenic regulation of soluble protein kinases and protein phosphorylation in rat ventral prostate. Arch. Biochem. Biophys., 244: 692, 1986.
12. Hansen, M. B., Nielsen, S. F. and Berg, K.: Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods, 119: 203, 1989.
13. Burns, R. F., Miller, F. D., Merriman, R. L., Howbert, J. J., Heath, W. F., Kobayashi, E., Takahashi, I., Tamaoki, T. and Nakano, H.: Inhibition of protein kinase C by calphostin C is light dependent. Biochem. Biophys. Res. Comm., 176: 288, 1991.
14. 3 pituitary cells. J. Biol. Chem., 262: 16759, 1987.
15. Brady, R. O., Kaufer, J. N., Mock, M. D. and Frederickson, D. S.: The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick disease. Proc. Natl. Acad. Sci., 55: 366, 1966.
16. Allessenko, A. and Chalterjee, S.: Neutral sphingomyelinase: localization in rat liver nuclei and involvement in regeneration/proliferation. Mol. Cell. Biochem., 143: 169, 1995.
17. Koybayashi, E., Nakano, H., Morimoto, M. and Tamaoki, T.: Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Comm., 159: 548, 1988.
18. Hannun, Y. A., Merrill, A. H. and Bell, R. M.: Use of sphingosine as inhibitor of protein kinase C. Methods Enzymology, 201: 316, 1991.
19. Reys-Moreno, C., Frenette, G., Boulanger, J., Lavergne, E., Govindau, M. V. and Koutsilieris, M.: Mediation of glucocorticoid receptor function by transforming growth factor beta 1 expression in human PC-3 prostate cancer cells. Prostate, 26: 260, 1995.
20. Sonnenschein, C., Olea, N., Pasaneu, M. E. and Soto, A. M.: Negative controls of cell proliferation: human prostate cancer cells and androgens. Cancer Res., 49: 3474, 1989.