Abnormal differentiation of thymocytes induced by free cyclosporine is avoided when cyclosporine bound to N-(2-hydroxypropyl)methacrylamide copolymer carrier is used

Transplantation

Volumn 63, Issue 12, 1997, Pages 1818-1827

  Št'astný, Marek ^a   Ulbrich, Karel ^b   Strohalm, Jiří ^b   Rossmann, Pavel ^a   Říhová, Blanka ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN; CYCLOSPORIN A; LIPOPROTEIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG BINDING; DRUG CONJUGATION; ELECTRON MICROSCOPY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIORECEPTOR ASSAY; T LYMPHOCYTE; THYMOCYTE;

ACRYLAMIDES; ANIMALS; BONE MARROW TRANSPLANTATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CONCANAVALIN A; CYCLOSPORINE; DRUG DELIVERY SYSTEMS; ERYTHROCYTES; FEMALE; IMMUNOSUPPRESSIVE AGENTS; LIPOPROTEINS; MALE; MICE; MICE, INBRED BALB C; POLYMERS; RATS; THYMUS GLAND;

EID: 0030913690     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199706270-00020     Document Type: Article

References (64)

1. Walker RJ, Duggin GG. Drug nephrotoxicity. Annu Rev Pharmacol Toxicol 1988; 28: 331.
2. Sullivan BA, Har LS, Finn WF. Cyclosporine nephrotoxicity: studies in laboratory animals. Transplant Proc 1985; 17(suppl 1): 145.
3. Argawal RP, McPherson RA, Threatte GA. Evidence of a CsA-binding protein in human erythrocytes. Transplantation 1987; 42: 627.
4. Lemaire M, Tillement JP. Role of lipoproteins and erythrocytes in the in vitro binding and distribution of CsA in the blood. J Pharm Pharmacol 1982; 34: 715.
5. Jenkins MK, Pardoll DM, Schwartz RH. Effects of CsA on T cell development and clonal deletion. Science 1988; 241: 1655.
6. Gao EK, Lo D, Cheney R, Kanagawa O, Sprent J. Abnormal differentiation of thymocytes in mice treated with CsA. Nature 1988; 336: 176.
7. Sorokin R, Kimura H, Schroder K, Wilson DH, Wilson DB. Cyclosporine A induced autoimmunity. J Exp Med 1986; 164: 1615.
8. Sakaguchi S, Sakaguchi N. Thymus and autoimmunity. J Exp Med 1988; 167: 1479.
9. Bucy RP, Xu XY, Li J, Huang G. Cyclosporine A-induced autoimmunity in mice. J Immunol 1993; 151: 1039.
10. Kopeček J, Rejmanová P, Chytrý V. Polymers containing enzymatically degradable bonds. I. Chymotrypsin catalyzed hydrolysis of p-nitroanilites of phenylalanine and tyrosine attached to side chains of copolymers of HPMA. Makromol Chem 1981; 182: 799.
11. Duncan R, Kopečková-Rejmanová P, Strohalm J, et al. Anticancer agents coupled to N-(2-hydroxypropyl) methacrylamide copolymers: evaluation of daunomycin and puromycin conjugates in vitro. Br J Cancer 1987; 55: 165.
12. Říhová B, Kopečková P, Strohalm J, Rossmann P, Větvička V, Kopeček J. Antibody directed affinity therapy applied to the immune system: in vivo effectiveness and limited toxicity of DNM conjugated to HPMA copolymers and targeting antibody. Clin Immunol Immunopathol 1988; 46: 100.
13. Říhová B, Kopeček J. Biological properties of targetable poly N-(hydroxypropyl) methacrylamide-antibody conjugates. J Controlled Release 1985; 2: 289.
14. Flanagan PA, Duncan R, Říhová B, Šubr V, Kopeček J. Immunogenicity of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates in A/J and B10 mice. J Bioact Compat Polymers 1990; 5: 151.
15. Říhová B, Jegorov A, Strohalm J, et al. Antibody-targeted CsA. J Controlled Release 1992; 19: 25.
16. Rejmanová P, Kopeček J, Pohl J, Baudyö M, Kostka V. Polymers containing enzymatically degradable bonds. VIII. Degradation of oligopeptide sequences in HPMA copolymers by bovine spleen cathepsin B. Makromol Chem 1983; 184: 2009.
17. Kopeček J. Reactive copolymers of N-(2-hydroxypropyl) methacrylamide with N-methacryloylated derivatives of L-leucine and L-phenylalanine. Makromol Chem 1977; 178: 2169.
18. Říhová B, Bilej M, Větvička V, Ulbrich K, Strohalm J, Kopeček J, Duncan R. Biocompatibility of HPMA copolymers containing adriamycin: immunogenicity and effect on hematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro. Biomaterials 1989; 10: 335.
19. Hašková V, Rozprimová L, Slavčev A, Jelínková M. Cyclophilin-immunofluorescence study of intracellular receptor for cyclosporin A. Immunol Rep (Czech) 1991; 6: 35.
20. Immunofluorescence and cell sorting. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds). Current protocols in immunology. New York, John Wiley & Sons, 1992: 5.3.2, 5.3.4.
21. Levey RH, Medawar PB. Some experiments on the action of antilymphoid antisera. Ann N Y Acad Sci 1966; 120: 164.
22. Bukovský A, Presl J, Židovský J, Mančal P. The localization of Thy 1.1, MRC OX 2 and Ia antigens in the rat ovary and fallopian tube. Immunology 1983; 48: 426
23. Rossmann P, Říha I, Matoušovic K, Bohdanecká M, Bukovský A. Experimental ablation nephropathy: fine structure, morphometry, cell membrane epitopes, glomerular polyanion and effect of subsequent transplantation. Pathol Res Pract 1990; 186: 491.
24. Ryffel B, Gotz V, Heuberger B. CsA receptors on human lymphocytes. J Imunol 1982; 129: 1978.
25. Niederberger W, Lemaire M, Maurer G, Nussbauchmer K, Wagner O. Distribution and binding of CsA in blood and tissues. Transplant Proc 1983; 15: 2419.
26. de Groen PC, Wilsner RH, Krom RAF. CsA-induced side effects related to a low total serum cholesterol level: an indication for a free CsA assay? Transplant Proc 1988; 20(suppl 2): 374.
27. Takeuchi Y, Horiuchi T, Sugimoto T, Matsuda H, Yagita H, Okumura K. Effects of cyclosporin A on T-cell development in organ-cultured fetal thymus. Immunology 1990; 71: 158
28. Kosugi A, Zuniga-Pflucker JC, Sharrow SO, Kruisbeek AM, Shearer GM II Developmental defects of immature and mature thymocytes in fetal thymus organ cultures treated with cyclosporin A. J Immunol 1989; 143: 3134.
29. Fukuzawa M, Sharrow SO, Shearer GM. Effect of cyclosporin A on T cell immunity. II. Defective thymic education of CD4 T helper cell function in cyclosporin A-treated mice. Eur J Immunol 1989; 19: 1147
30. -) immature thymocytes in newborn mice. Scand J Immunol 1989; 30: 703.
31. Urdahl KB, Pardoll DM, Jenkins MK. Cyclosporin A inhibits positive selection and delays negative selection in alpha/beta TCR transgenic mice. J Immunol 1994; 152: 2853.
32. Sakaguchi S, Sakaguchi N. Thymus and autoimmunity: transplantation of the thymus from cyclosporin A-treated mice causes organ-specific autoimmune disease in athymic nude mice. J Exp Med 1988; 167: 1479.
33. Sakaguchi S, Sakaguchi N. Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. J Immunol 1989; 142: 471.
34. Schreiber SL, Crabtree GR. The mechanism of action of CsA and FK-506. Immunol Today 1992; 13: 136.
35. Liu J, Farmer JDJ, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-CsA and FKBP-FK-506 complexes. Cell 1991; 66: 807.
36. Jugnu J, McCaffrey P, Miner Z, et al. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 1993; 365: 352.
37. Jenkinson EJ, Kingston R, Owen JJT. Importance of IL-2 receptors in intrathymic generation of cells expressing T-cell receptors. Nature 1987; 329: 160.
38. Tentori L, Longo DL, Zuniga-Pflucker JC, Wing C, Kruisbeek AM. Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo. J Exp Med 1988; 168: 1741.
39. + lineage of T cells in mice treated neonatally with anti- I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function. J Exp Med 1985; 161: 1029.
40. Deluca D. I-A-positive nonlymphoid cells and T cell development in murine fetal thymus organ cultures: monoclonal anti-I-A antibodies inhibit the development of T cells. J Immunol 1986; 136: 430.
41. Kroemer G, Martinez-A C. Pharmacological inhibition of programmed lymphocyte death. Immunol Today 1994; 15: 235.
42. Yasutomi D, Odaka C, Saito S, Niizeki H, Kizaki H, Tadakuma T. Inhibition of programmed cell death by cyclosporin A: preferential blocking of cell death induced by signals via TCR/CD3 complex and its mode of action. Immunology 1992; 77: 68.
43. Fruman DA, Burakoff SJ, Bierer BE. Correlation of calcineurin phosphatase activity and programmed cell death in T-cell hybridomas. Eur J Immunol 1992; 22: 2513.
44. Shi YF, Sahai BM, Green DR. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature 1989; 339: 625.
45. Yazdanbakhsh K, Choi JW, Li Y, Lau LF, Choi Y. Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77. Proc Natl Acad Sci USA 1995; 92: 437.
46. Cohen JJ, Duke RC. Apoptosis and programmed cell death in immunity. Annu Rev Immunol 1992; 10: 267.
47. Prud'homme GJ, Vanier LE. CsA, tolerance and autoimmunity. Clin Immunol Immunopathol. 1993; 66: 185.
48. Ritter MA, Boyd RL. Development in the thymus: it takes two to tango. Immunol Today 1993; 14: 462.
49. Boyd RL, Tucek CL, Godfrey DI, et al. The thymic microenvironment. Immunol Today 1993; 14: 445.
50. Boyd RL, Hugo P. Towards an integrated view of thymopoiesis. Immunol Today 1991; 12: 71.
51. Surh CD, Ernst B, Sprent J. Growth of epithelial cells in the thymic medulla is under the control of mature T cells. J Exp Med 1992; 176: 611.
52. van Ewijk W, Shores EW, Singer A. Crosstalk in the mouse thymus. Immunol Today 1994; 15: 214.
53. Shores EW, van Ewijk W, Singer A. Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative SCID mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment. Eur J Immunol 1991; 21: 1657.
54. 125I/daunomycin. J Controlled Release 1989; 10: 37.
55. Šubr V, Kopeček J, Pohl J, Baudyö M, Kostka V. Cleavage of oligopeptide side chains in HPMA copolymers by mixtures of lysosomal enzymes. J Controlled Release 1988; 8: 133.
56. Rejmanová P, Kopeček J, Duncan R, Lloyd JB. Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in HPMA copolymers. Biomaterials 1985; 6: 45.
57. Konvalainen K, Gitlin D. Passage of antigens across the vascular barrier of the thymus. Nature 1967; 214: 592.
58. Raviola E, Karnovsky MJ. Evidence for a blood-thymus barrier using electron- opaque tracers. J Exp Med 1972; 136: 446.
59. Kyewski BA, Fathman CG, Rouse RV. Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells: an antigen-dependent microenvironment for T cell differentiation. J Exp Med 1986; 163: 231.
60. Stet RJM, Wagennar-Hilbers JPA, Nieuwenhuis P. Thymus localization of monoclonal antibodies circumventing the blood-thymus barrier. Scand J Immunol 1987; 25: 441.
61. Nieuwenhuis P, Stet RJM, Wagenaar JPA, Wubbena AS, Kampinga J, Karrenbeld A. The transcapsular route: a new way for (self-) antigens to by-pass the blood-thymus barrier? Immunol Today 1988; 9: 372.
62. Risau W. Differentiation of endothelium. FASEB J 1995; 9: 926.
63. Agus DB, Surh CD, Sprent J. Reentry of T cells to the adult thymus is restricted to activated T cells. J Exp Med 1991; 173: 1039.
64. Brodehl J, Offner G, Hoyer PF, Schirg E, Pichlmayr R, Wonigeit K. Cyclosporin A in pediatric kidney transplantation and its effects on posttransplantation growth. Nephron 1986; 44: 26.