Efficacy of artemisinin and mefloquine combinations against Plasmodium falciparum. In vitro simulation of in vivo pharmacokinetics

Tropical Medicine and International Health

Volumn 2, Issue 5, 1997, Pages 461-467

  Bwijo, B ^a   Hassan Alin, M ^a,b   Abbas, N ^a   Wernsdorfer, W ^c   Bjorkman A ^a,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c UNIVERSITY OF VIENNA   (Austria)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Artemisinin; Combinations; In vitro; Malaria; Mefloquine; Plasmodium falciparum

Indexed keywords

ARTEMISININ; CHLOROQUINE; MEFLOQUINE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACOKINETICS; PLASMODIUM FALCIPARUM; SIMULATION;

EID: 0030913192     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3156.1997.tb00168.x     Document Type: Article

References (15)

1. Bunnag D, Kanda T, Karbwang J, Thimasarn K, Pungpak S & Harinasuta T (1995) Artemether-mefloquine combination in multidrug resistant falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 89, 213-215.
2. Chawira AN & Warhurst DC (1987) Effects of artemisinin combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro, Journal of Tropical Medicine and Hygiene 90, 1-8.
3. Chawira AN, Warhurst DC, Robinson BL & Peters W (1987) The effects of combinations of quinghaosu (artemisinin) with standard antimalaria drugs in the suppressive treatment of malaria in mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 554-558.
4. Duc DD, De Vries PJ, Khanh NX, Binh LN & Kager PA (1994) The pharmacokinetics of a single dose of artemisinin in healthy Vietnamese subjects. American Journal of Tropical Medicine and Hygiene 51, 785-790.
5. Ekong R & Warhurst DC (1990) Synergism between arteether and mefloquine or quinine in a multidrug-resistant strain of Plasmodium falciparum in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 757-758.
6. Hassan Alin M, Ashton M, Kihamia CM, Mtey GJB & Björkman A (1996) Multiple dose pharmacokinetics of artemisinin and comparison of its efficacy with, that of artesunate in falciparum malaria patients. Transactions of the Royal Society of Tropical Medicine and Hygiene 90, 61-65.
7. Hassan Alin M, Ashton M, Kihamia CM, Mtey GJB & Björkman A (1996). Clinical efficacy and pharmacokinetics of artemisinin monotherapy and in combination with mefloquine in patients with falciparum malaria. British Journal of Clinical Pharmacology 41, 587-592.
8. Karbwang J & White N (1990) Clinical Pharmacokinetics of mefloquine. Clinical Pharmacokinetics 19, 264-279.
9. Karbwang J, Na Bangchang K, Thanavihul A, Ditta in M & Harinasuta T (1995) A comparative clinical trial of two different regimens of artemether plus mefloquine in multidrug-resistant falciparum malaria. Transaction of the Royal Society of Tropical Medicine and Hygiene 89, 296-298.
10. Looareesuwan S, Vanijanonta S, Viravan, Wilairatana, Charoenlarp P & Andrial M (1994) Randomized trial of mefloquine alone and artesunate followed by mefloquine for treatment of acute uncomplicated malaria. Annals of Tropical Medicine and Parasitology 88, 131-136.
11. Luxemburger C, ter Kuile FO, Nosten F et al (1994) Single day mefloquine-artesunate combination in the treatment of multi-drug resistant falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 88, 213-217.
12. Nosten F, Luxemburger C, ter-Kuile et al (1994) Treatment of multidrug-resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination. Journal of Infectious Diseases 170, 971-977.
13. Shwe T & Hla KK (1991) The effect of artemether plus mefloquine on Myanmar patients with complicated falciparum malaria. Southeast Asian Journal of Tropical Medicine and Public Health Suppl 4, 117-121.
14. Win K, Than M & Thwe Y (1992) Comparison of combinations of parenteral artemisinin derivatives plus oral mefloquine with intravenous quinine plus oral tetracycline for treating cerebral malaria. Bulletin of the World Health Organization 70, 777-782.
15. Ye Z, Li Z, Li G, Xiangji F & Hepei L (1983) Effects of quinghaosu and chloroquine on the ultrastructure of the erythrocytic stage of P. falciparum in continuous cultivation in vitro, Journal of Traditional Chinese Medicine 3, 95-101.