L-α-aminoadipate reduces glutamate release from brain tissue exposed to combined oxygen and glucose deprivation

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 5, 1997, Pages 567-570

  Haugstad, Tor S ^a   Langmoen, Iver A ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

amino acid release; brain slices; cerebral ischemia; GABA; glutamate; L aminoadipate

Indexed keywords

2 AMINOADIPIC ACID; 4 AMINOBUTYRIC ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMIC ACID DERIVATIVE; OXYGEN;

4 AMINOBUTYRIC ACID RELEASE; AMINO ACID TRANSPORT; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; HIPPOCAMPUS; HYPOGLYCEMIA; INFLAMMATION; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; RAT;

EID: 0030912833     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199705000-00011     Document Type: Article

References (37)

1. Aas J-E, Berg-Johnsen J, Hegstad E, Laake JH, Langmoen IA, Ottersen OP (1993) Redistribution of glutamate and glutamine in slices of human neocortex exposed to combined hypoxia and glucose deprivation in vitro. J Cereb Blood Flow Metab 13:503-515
2. Bannai S (1986) Exchange of cystine and glutamate across plasma membrane of human fibroblasts. J Biol Chem 261:2256-2263
3. Christensen HN (1984) Organic ion transport during seven decades. The amino acids. Biochim Biophys Acta 779:255-269
4. Clements JD, Lester RAJ, Tong G, Jahr CE, Westbrook GL (1992) The time course of glutamate in the synaptic cleft. Science 258:1498-1501
5. Danbolt NC (1994) The high affinity uptake system for excitatory amino acids in the brain. Prog Neurobiol 44:377-396
6. Fykse EM, Fonnum F (1988) Uptake of γ-aminobutyric acid by a synaptic vesicle fraction isolated from rat brain. J Neurochem 50: 1237-1242
7. Fykse EM, Iversen EG, Fonnum F (1992) Inhibition of L-glutamate uptake into synaptic vesicles. Neurosci Lett 135:125-128
8. Guastella J, Nelson N, Nelson H, Czyzyk L, Keynan S, Miedel MC, Davidson N, Lester HA, Kanner BI (1990) Cloning and expression of a rat brain GABA transporter. Science 249:1303-1306
9. Hansen AJ, Zeuthen T (1981) Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex. Acta Physiol Scand 113:437-445
10. Haugstad TS (1996) Mechanisms of Amino Acid Release during Cerebral Ischemia. Ph.D. Thesis, University of Oslo, Norway.
11. Haugstad TS, Langmoen IA (1995) Effect of glutamate uptake inhibitors on glutamate released from rat brain during energy deprivation. J Cerb Blood Flow Metab 15(suppl):S260
12. Haugstad TS, Langmoen IA (1996) Release of brain amino acids during hyposmolar stress and energy deprivation. J Neurosurg Anesth 8:159-168
13. Haugstad TS, Valø ET, Langmoen IA (1995) Changes in brain amino acid content induced by hyposmolar stress and energy deprivation. Neurol Res 17:402-408
14. Hegstad E, Berg-Johnsen J, Haugstad TS, Hauglie-Hanssen E, Langmoen IA (1996) Amino-acid release from human cerebral cortex during simulated ischemia in vitro. Acta Neurochir 138:234-241
15. Hegstad E, Haugeto Ø, Langmoen IA (1995) Glutamate transport in slices from human cerebral cortex maintained in vitro. Doctoral Thesis, University of Oslo, Norway.
16. Hegstad E, Haugstad TS, Hauglie-Hanssen E, Langmoen IA (1993) Amino acid release from human cerebral cortex during simulated ischemia. J Cereb Blood Flow Metab 13(suppl):S756
17. Ikeda M, Nakazawa T, Abe K, Kaneko T, Yamatsu K (1989) Extracellular accumulation of glutamate in the hippocampus induced by ischemia is not calcium dependent - in vitro and in vivo evidence. Neurosci Lett 96:202-206
18. Kanai Y, Hediger MA (1992) Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360: 467-471
19. Katayama Y, Kawamata T, Tamura T, Hovda DA, Becker DP, Tsubokawa T (1991) Calcium-dependent glutamate release concomitant with massive potassium flux during cerebral ischemia in vivo. Brain Res 558:136-140
20. Kato S, Ishita S, Sugawara K, Mawatari K (1993) Cystine/glutamate antiporter expression in retinal Müller glial cells: implications for DL-alpha-aminoadipate toxicity. Neuroscience 57:473-482
21. Kimelberg HK, Godrie SK, Higman S, Pang S, Waniewski RA (1990) Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures. J Neurosci 10:1583-1591
22. Klöckner U, Storck T, Conradt M, Stoffel W (1994) Functional properties and substrate specificity of the cloned L- glutamate/L-aspartate transporter GLAST-1 from rat brain expressed in Xenopus oocytes. J Neurosci 14:5759-765
23. Langmoen IA, Andersen P (1981) The hippocampal slice in vitro. A description of the technique and some examples of the opportunities it offers. In: Electrophysiology of Isolated Mammalian CNS Preparations (Kerkut GA, Wheal H, eds) London, Academic Press, pp 51-105
24. Logan WJ, Snyder SH (1971) Unique high affinity uptake systems for glycine, glutamic and aspartic acids in central nervous tissue of the rat. Nature 234:297-299
25. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
26. Lund Karlsen R (1978) The toxic effect of sodium glutamate and DL-α-aminoadipic acid on the inner layers of the retina: changes in high affinity uptake of putative neurotransmitters. J Neurochem 1055-1061
27. Maycox PR, Hell JW, Jahn R (1990) Amino acid neurotransmission: spotlight on synaptic vesicles. Trends Neurosci 13:83-87
28. McBean GJ (1994) Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, αaminoadipate. Br J Pharmacol 113:536-540
29. Miura K, Ishii T, Sugita Y, Bannai S (1992) Cystine uptake and glutathione level in endothelial cells exposed to oxidative stress. Am J Physiol 262:C50-C58
30. Naito S, Ueda T (1985) Characterization of glutamate uptake into synaptic vesicles. J Neurochem 44:99-109
31. Nicholls D, Attwell D (1990) The release and uptake of excitatory amino acids. Trends Pharmacol Sci 11:462-468
32. Olney JW, Ho OL, Rhee V (1971) Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system. Exp Brain Res 14:61-76
33. c in the macrophage-induced glutamate-dependent cytotoxicity to neurons. J Immunol 152:3578-3585
34. Pines G, Danbolt NC, Bjørås M, Zhang Y, Bendahan A, Eide L, Koepsell H, Storm-Mathisen J, Seeberg E, Kanner BI (1992) Cloning and expression of a rat brain L-glutamate transporter. Nature 360: 464-467
35. 3[H]glutamate transport processes in rat brain. Brain Res 544:196-202
36. Waniewski RA, Martin DL (1984) Characterization of L-glutamic acid transport by glioma cells in culture: evidence for sodium-independent, chloride-dependent high affinity influx. J Neurosci 4:2237-2246
37. Watkins JC, Krogsgaard-Larsen P, Honoré T (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharmacol Sci 11: 25-33