Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase

Protein Science

Volumn 6, Issue 6, 1997, Pages 1352-1357

  Kobe, Bostjan ^a   Jennings, Ian G ^b   House, Colin M ^a   Feil, Susanne C ^a   Michell, Belinda J ^a   Tiganis, Tony ^a   Parker, Michael W ^a   Cotton, Richard G H ^b   Kemp, Bruce E ^a  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b Mutation Research Centre   (Australia)

Author keywords

Crystallization; Phenylalanine hydroxylase; Protein phosphorylation; Quaternary structure; X ray crystallography

Indexed keywords

PHENYLALANINE 4 MONOOXYGENASE;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN QUATERNARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

EID: 0030912603     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560060626     Document Type: Article

References (51)

1. Abita JP, Milstien S, Chang N, Kaufman S. 1976. In vitro activation of rat liver phenylalanine hydroxylase by phosphorylation. J Biol Chem 251:5310-5314.
2. Abita JP, Parniak M, Kaufman S. 1984. The activation of rat liver phenylalanine hydroxylase by limited proteolysis, lysolecithin, and tocopherol phosphate. J Biol Chem 259:14560-14566.
3. Aitken A. 1992. Structure determination of acylated proteins. In: Hooper NM, Turner AJ, eds. Lipid modification of proteins. A practical approach. Oxford: IRL Press. pp 63-88.
4. Barford D, Hu SH, Johnson LN. 1991. Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP. J Mol Biol 218:233-260.
5. Barford D, Johnson LN. 1989. Allosteric transition of glycogen phosphorylase. Nature 340:609-616.
6. Celikel R, Davis MD, Dai X, Kaufman S, Xuong NH. 1991. Crystallization and preliminary X-ray analysis of phenylalanine hydroxylase from rat liver. J Mol Biol 218:495-498.
7. Chiapelli F, Haggerty DF, Lynch M, Popjak G. 1981. Translation of phenylalanine hydroxylase-specific mRNA in vitro: Evidence for pretranslational control by glucocorticoids. Proc Natl Acad Sci USA 78:2105-2109.
8. Citron BA, Davis DM, Kaufman S. 1994. Electrostatic activation of rat phenylalanine hydroxylase. Biochem Biophys Res Commun 198:174-180.
9. Dahl HHM, Mercer JFB. 1986 Isolation and sequence of a cDNA clone which contains the complete coding region of rat phenylalanine hydroxylase. J Biol Chem 261:4148-4153.
10. De Bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH. 1993. Crystal structure of cyclin-dependent kinase 2. Nature 363:595-602.
11. Dean AM, Koshland DE Jr. 1991. Electrostatic and steric contributions to regulation at the active site of isocitrate dehydrogenase. Science 249:1044-1046.
12. Donlon J, Kaufman S. 1978. Glucagon stimulation of rat hepatic phenylalanine hydroxylase through phosphorylation in vivo. J Biol Chem 253:6657-6659.
13. Døskeland AP, Døskeland SO, Øgreid D, Flatmark T. 1984. The effect of ligands of phenylalanine 4-monooxygenase on the cAMP-dependent phosphorylation of the enzyme. J Biol Chem 259:11242-11248.
14. Døskeland AP, Haavik J, Flatmark T, Døskeland SO. 1987. Modulation by pterins of the phosphorylation and phenylalanine activation of phenylalanine 4-mono-oxygenase. Biochem J 242:867-874.
15. Døskeland AP, Martinez A, Knappskog PM, Flatmark T. 1996. Phosphorylation of recombinant human phenylalanine hydroxylase: Effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease. Biochem J 313:409-414.
16. Fisher DB, Kaufman S. 1973. The stimulation of rat liver phenylalanine hydroxylase by lysolecithin and α-chymotrypsin. J Biol Chem 245:4345-4353.
17. Gibbs BS, Wojchowski D, Benkovic SJ. 1993. Expression of rat liver phenylalanine hydroxylase in insect cells and site-directed mutagenesis of putative non-heme iron-binding sites. J Biol Chem 268:8046-8052.
18. Haavik J, Døskeland AP, Flatmark T. 1986. Stereoselective effects in the interactions of pterin cofactors with rat-liver phenylalanine 4-monooxygenase. Eur J Biochem 160:1-8.
19. 2+/S100 regulation of giant protein kinases. Nature 380:636-639.
20. Hufton SE, Jennings IG, Cotton RGH. 1995. Structure and function of the aromatic amino acid hydroxylases. Biochem J 311:353-366.
21. Hurley JH, Dean AM, Sohl JL, Koshland DE Jr, Stroud RM. 1991. Regulation of an enzyme by phosphorylation at the active site. Science 249:1012-1016.
22. Iwaki M, Phillips RS, Kaufman S. 1986. Proteolytic modification of the amino-terminal and carboxyl-terminal regions of rat hepatic phenylalanine hydroxylase. J Biol Chem 261:2051-2056.
23. Jancarik J, Kim SH. 1991. Sparse matrix sampling: A screening method for crystallization of proteins. J Appl Crystallogr 24:409-411.
24. Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz G, Massague J, Pavletich NP. 1995. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 376:313-320.
25. Jervis JA. 1947. Studies on phenylpyruvic oligophrenia. The position of the metabolic error. J Biol Chem 169:651-656.
26. Johnson LN, Barford D. 1993. The effects of phosphorylation on the structure and function of proteins. Annu Rev Biophys Biomol Struct 22:199-232.
27. Kaufman S. 1993. The phenylalanine hydroxylating system. Adv Enzymol 67:77-264.
28. Kaufman S, Fisher DB. 1970. Purification and some physical properties of phenylalanine hydroxylase from rat liver. J Biol Chem 245:4745-4750.
29. Kobe B, Heierhorst J, Feil SC, Parker MW, Benian GM, Weiss KR, Kemp BE. 1996. Giant protein kinases: Domain interactions and structural basis of autoregulalion. EMBO J 15:6810-6821.
30. Konecki DS, Wang Y, Trefz FK, Lichter-Konecki U, Woo SLC. 1992. Structural characterization of the 5′ regions of the human phenylalanine hydroxylase gene. Proc Natl Acad Sci USA 31:8363-8368.
31. Kowlessur D, Yang XJ, Kaufman S. 1995. Further studies of the role of Ser-16 in the regulation of the activity of phenylalanine hydroxylase. Proc Natl Acad Sci USA 92:4743-4747.
32. Lazarus RA, Dietrich RF, Wallick DE, Benkovic SJ. 1981. On the mechanism of action of phenylalanine hydroxylase. Biochemistry 20:6834-6841.
33. Lin K, Rath VL, Dai SC, Fletterick RJ, Hwang PK. 1996. A protein phosphorylation switch at the conserved allosteric site in GP. Science 273:1539-1541.
34. Liu X, Vrana KE. 1991. Leucine zippers and coiled-coils in the aromatic amino acids hydroxylases. Neurochem Int 18:27-31.
35. Markey KA, Kondo S, Shenkman L, Goldstein M. 1980. Purification and characterization of tyrosine hydroxylase from a clonal pheochromocytoma cell line. Mol Pharmacol 17:79-84.
36. McPherson A. 1982. Preparation and analysis of protein crystals. New York: John Wiley and Sons.
37. Nakata H, Fujisawa H. 1980. Purification and characterization of phenylalanine 4-monooxygenase from rat liver. Biochim Biophys Acta 614:313-327.
38. Nakata H, Fujisawa H. 1982. Tryptophan 5-monooxygenase from mouse mastocytoma P815. Eur J Biochem 124:595-601.
39. Otwinowski Z. 1993. Data collection and processing. In: Sawyer L, Isaacs N, Bailey S, eds. Proceedings of the CCP4 study weekend. Daresbury, UK: SERC, Daresbury Laboratory. pp 56-62.
40. Parniak MA. 1987. Organization of the catalytic and regulatory sites of rat liver phenylalanine hydroxylase. In: Curtius H-Ch, Blau M, eds. Unconjugated pterines and related biogenic amines. Berlin: de Gruyter. pp 327-337.
41. Rath VL, Fletterick RJ. 1994. Parallel evolution in two homologues of phosphorylase. Nature Struct Biol 1:681-689.
42. Russo AA, Jeffrey PD, Pavletich NP 1996. Structural basis of cyclin-dependent kinase activation by phosphorylation. Nature Struct Biol 3:696-700.
43. Sakabe N. 1991. X-ray diffraction data collection system for modern protein crystallography with a Weissenberg camera and an imaging plate using synchrotron radiation. Nucl Instr Meth Phys Res ,4303:448-463.
44. Scriver CR, Eisensmith RC, Woo SLC, Kaufman S. 1994. The hyperphenylalaninemias of man and mouse. Annu Rev Genet 25:141-165.
45. Shiman R, Gray DW. 1980. Substrate activation of phenylalanine hydroxylase. A kinetic characterization. J Biol Chem 255:4793-4800.
46. Shiman R, Gray DW, Pater A. 1979. A simple purification of phenylalanine hydroxylase by substrate-induced hydrophobic chromatography. J Biol Chem 254:11300-11306.
47. Sprang SR, Acharya KR, Goldsmith EJ, Stuart DI, Varvill K, Fletterick RJ, Madsen NB, Johnson LN. 1988. Structural changes in glycogen phosphorylase induced by phosphorylation. Nature 336:215-221.
48. Tong JH, Kaufman S. 1975. Tryptophan hydroxylase. J Biol Chem 250:4152-4158.
49. Vrana KE, Walker SJ, Rucker P, Liu X. 1996. A carboxyl terminal leucine zipper is required for tyrosine hydroxylase tetramer formation. J Neurochem 63:2014-2020.
50. Wretborn M, Humble E, Ragnarsson U, Engstrom L. 1980. Amino acid sequence at the phosphorylation site of rat liver phenylalanine hydroxylase and phosphorylation of a corresponding peptide. Biochem Biophys Res Commun 93:403-408.
51. Yonemoto WM, McGlone ML, Slice LW, Taylor SS. 1990. Prokaryotic expression of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase. Methods Enzymol 200:581-597.