Resuscitation from hemorrhagic shock with diaspirin cross-linked hemoglobin, blood, or hetastarch

Journal of Trauma - Injury, Infection and Critical Care

Volumn 42, Issue 3, 1997, Pages 406-414

  DeAngeles, D A ^a   Scott, A M ^a   McGrath, A M ^a   Korent, V A ^a   Rodenkirch, L A ^a   Conhaim, Robert L ^a,b   Harms, B A ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

Author keywords

Acid base imbalance; Anoxia; Blood substitutes; Fluid therapy; Hemorrhagic shock; Lactic acidosis; Oxygen consumption; Oxygen deficiency

Indexed keywords

ACETYLSALICYLIC ACID; HETASTARCH;

ACID BASE BALANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOXIA; BLOOD SUBSTITUTION; BLOOD VOLUME; CONFERENCE PAPER; CONTROLLED STUDY; CROSS LINKING; FLUID THERAPY; HEMORRHAGIC SHOCK; HYPOXIA; LACTIC ACIDOSIS; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PRIORITY JOURNAL; RESUSCITATION; SHEEP;

EID: 0030911905     PISSN: 00225282     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005373-199703000-00007     Document Type: Conference Paper

References (21)

1. Dunham CM, Siegel JH, Weireter L, et al: Oxygen debt and metabolic acidemia as qualitative predictors of mortatlity and the severity of the ischemic insult in hemorrhagic shock. Crit Care Med 2:231, 1991
2. Davis JW, Shackford SR, Holbrook TL: Base deficit as a sensitive indicator of compensated shock and tissue oxygen utilization. Surg Gynecol Obstet 173:473, 1991
3. Durham RM, Neunaber K, Mazuski JE, et al: The use of oxygen consumption and delivery as endpoints for resuscitation in critically ill patients. J Trauma 41:32, 1996
4. Chatterjee R, Welty EV, Walder RY, et al: Isolation and characterization of a new hemoglobin derivative cross-linked between the alpha chains (lysine 99 alpha 1 - lysine 99 alpha 2). J Biol Chem 261:9929, 1986
5. Snyder SR, Welty LV, Walder RY, et al: HbXL99a: A hemoglobin derivative that is cross-linked between the subunits is useful as a blood substitute. Proc Natl Acad Sci USA 84:7280, 1987
6. Farmer M, Ebeling A, Marshall T, et al: Validation of virus inactivation by heat treatment in the manufacture of diaspirin cross-linked hemoglobin. In Chang T (ed): Blood Substitutes and Oxygen Carriers. New York, Marcel Dekker, 1989, pp 246-250
7. Nelson D, Azari M, Brown R, et al: Preparation and characterization of diaspirin cross-linked hemoglobin solutions for preclinical studies. Biomaterial Artificial Cells Immobilization Biotechnology 20:423, 1992
8. Hedrick MS, Ryan ML, Pizarro J, et al: Modulation of respiratory rhythm by alpha 2-adrenoceptors in awake and anesthetized goats. J Appl Physiol 77:742, 1994
9. Berne RM, Levy MN, Eds. Gas exchange and gas transport. In Physiology. St. Louis, Mo, C.V. Mosby Company, 1988, pp 605-606
10. Rosen AL, Sehgal LR, Gould SA, et al: Methodology to assess the oxygen concentration of red cells and stroma-free hemoglobin solutions. Crit Care Med 14:147, 1986
11. Feldman DS, Gagnon J, Hofmann R, et al: Stat View II™, version 1.03. Berkeley, CA, Abacus Concepts, 1991
12. SAS Institute, Inc. Technical Report P-229: SAS/STAT Software: Changes and Enhancements, release 6.07. Cary, NC, SAS Institute, Inc., 1992
13. Przybelski RJ, Daily EK: The pressor/perfusion effect of diaspirin cross-linked hemoglobin (DCLHb™). Yearbook Intensive Care and Emergency Medicine, New York, Springer-Verlag, 1994, pp 252-263
14. Schultz SC, Hamilton IN, Malcolm DS: Use of base deficit to compare resuscitation with lactated Ringer's solution, haemaccel, whole blood, and diaspirin cross-linked hemoglobin following hemorrhage in rats. J Trauma 4:619, 1993
15. Bishop MH, Wo CJ, Appel PL, et al: Relationship between supranormal circulatory values, time delays and outcome in severely traumatized patients. Crit Care Med 21:56, 1993
16. Bishop MH, Shoemaker WC, Appel PL, et al: Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma. J Trauma 5:780, 1995
17. Taylor AE, Adkins WK, Wilson P, et al: Regulation of capillary exchange of fluid and protein. In Ayres SM, Grenvik A, Holbrook PR, et al (eds): Textbook of Critical Care, 3rd ed. Philadelphia, WB Saunders, 1995, pp 659-673
18. Cohn SM, Farrell TJ: Diaspirin cross-linked hemoglobin resuscitation of hemorrhage: Comparison of a blood substitute with hypertonic saline and isotonic saline. J Trauma 39:210, 1995
19. Hamilton I, Schultz SC, Cole F, et al: Characterization of diaspirin cross-linked hemoglobin's pressor response. Crit Care Med 20:S106, 1992
20. Nolte D, Botzlar A, Hecht R, et al: Diaspirin crosslinked hemoglobin: Evaluation of effects on the microcirculation of striated muscle. Artificial Cells, Blood Substitutes, & Immobilization Biotechnology 22:587, 1994
21. Nolte D, Pickelmann A, Botzlar A, el al: Effects of diaspirin-crosslinked hemoglobin (DCLHb™) on local lissue oxygen tension in striated skin muscle after resuscitation from severe hemorrhagic shock. Artificial Cells, Blood Substitutes, & Immobilization Biotechnology 24:394, 1996