Psychomotor effects of dopamine infusion under decreased glutathione conditions

Free Radical Biology and Medicine

Volumn 23, Issue 3, 1997, Pages 412-418

  Shukitt Hale, Barbara ^a,b   Denisova, Natalia A ^a   Strain, Joy G ^a   Joseph, James A ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Aging; Buthionine sulfoximine; Dopamine; Free radicals; Glutathione; Motor behavior; Oxidative stress; Performance

Indexed keywords

ANTIOXIDANT; BUTHIONINE SULFOXIMINE; DOPAMINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; REACTIVE OXYGEN METABOLITE; RINGER SOLUTION;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN LEVEL; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; GLUTATHIONE METABOLISM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MOTOR DYSFUNCTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT; WALKING;

AGING; ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; BRAIN; BUTHIONINE SULFOXIMINE; DOPAMINE; GLUTATHIONE; MALE; OXIDATIVE STRESS; PSYCHOMOTOR PERFORMANCE; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0030911665     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(97)00094-4     Document Type: Article

References (32)

1. Ames B. N., Shigenaga M. K., Hagen T. M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA. 90:1993;7915-7922.
2. Harman D. Role of free radicals in aging and disease. Ann. NY Acad. Sci. 673:1992;126-141.
3. Carney J. M., Starke-Reed P. E., Oliver C. N., Landum R. W., Cheng M. S., Wu J. F., Floyd R. A. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl- α -phenylnitrone. Proc. Natl. Acad. Sci. USA. 88:1991;3633-3636.
4. Olanow C. W. An introduction to the free radical hypothesis in Parkinson's disease. Ann. Neurol. 32:1992;S2-S9.
5. Lopez G. H., Ilincheta de Boschero M. G., Castagnet P. I., Giusto N. M. Age-associated changes in the content and fatty acid composition of brain glycerophospholipids. Comp. Biochem. Physiol. 112B:1995;331-343.
6. Vogt B. L., Richie J. P. Fasting-induced depletion of glutathione in the aging mouse. Biochem. Pharmacol. 46:1993;257-263.
7. Chen T. S., Richie J. P., Lang C. A. The effect of aging on glutathione and cysteine levels in different regions of the mouse brain. Proc. Soc. Exp. Biol. Med. 190:1989;399-402.
8. Mo J. Q., Hom D. G., Andersen J. K. Decreases in protective enzymes correlates with increased oxidative damage in the aging mouse brain. Mech. Ageing Dev. 81:1995;73-82.
9. Carney J. M., Smith C. D., Carney A. M., Butterfield D. A. Aging- and oxygen-induced modifications in brain biochemistry and behavior. Ann. NY Acad. Sci. 738:1994;44-53.
10. Pileblad E., Magnusson T. Effective depletion of glutathione in rat striatum and substantia nigra by L-buthionine sulfoximine in combination with 2-Cyclohexene-1-one. Life Sci. 47:1990;2333-2342.
11. Vanella A., Di Giacomo C., Sorrenti V., Russo A., Castorina C., Campisi A., Renis M., Perez-Polo J. R. Free radical scavenger depletion in post-ischemic reperfusion brain damage. Neurochem. Res. 18:1993;1337-1340.
12. Griffith O. W. Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J. Biol. Chem. 257:1982;13704-13712.
13. Hastings T. G., Lewis D. A., Zigmond M. J. Role of oxidation in the neurotoxic effects of intrastriatial dopamine injections. Proc. Natl. Acad. Sci. USA. 93:1996;1956-1961.
14. Rabinovic A. D., Zigmond M. J., Hastings T. G. Intrastriatial dopamine oxidizes to quinones: Role of endogenous glutathione. Soc. Neurosci. Abst. 20:1994;413.
15. Mytilineou C., Han S., Cohen G. Toxic and protective effects of L-DOPA on mesencephalic cell cultures. J. Neurochem. 61:1993;1470-1478.
16. 3H] dopamine: Impact of ascorbic acid and glutathione. J. Neurochem. 63:1994;1126-1132.
17. Hastings T. G. Enzymatic oxidation of dopamine: The role of prostaglandin H synthase. J. Neurochem. 64:1995;919-924.
18. Joseph J. A. The putative role of free radicals in the loss of neuronal functioning in senescence. Integ. Physiol. Behav. Sci. 27:1992;216-227.
19. Dean R. L., Scozzafava J., Goas J. A., Regan B., Beer B., Bartus R. T. Age-related differences in behavior across the life span of the C57BL/6J mouse. Exp. Aging Res. 7:1981;427-451.
20. Ingram D. K., Jucker M., Spangler E. L. Behavioral manifestations of aging. Mohr U., Cungworth D. L., Capen C. C. Pathobiology of the aging rat. 2:1994;149-170 ILSI Press, Washington, DC.
21. Joseph J. A., Bartus R. T., Clody D., Morgan D., Finch C., Beer B., Sesack S. Psychomotor performance in the senescent rodent: Reduction of deficits via striatal dopamine receptor up-regulation. Neurobiol. Aging. 4:1983;313-319.
22. Joseph J. A., Lippa A. S. Reduction of motor behavioral deficits in senescent animals via chronic prolactin administration - II. Non-stereotypic behaviors. Neurobiol. Aging. 7:1986;37-40.
23. Pileblad E., Magnusson T. Marked reduction of rat brain glutathione following intracerebroventricular administration of the glutathione synthesis inhibitor L-buthionine sulfoximine. Neurosci. Lett. 95:1988;302-306.
24. Pileblad E., Magnusson T. Intracerebroventricular administration of L-buthionine sulfoximine: A method for depleting brain glutathione. J. Neurochem. 53:1989;1878-1882.
25. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 2nd ed. 1986;Academic, Orlando.
26. 14C-glycine. J. Biol. Chem. 222:1956;581-585.
27. Owens C. W. I., Belcher R. V. A colorimetric micro-method for the determination of glutathione. Biochem. J. 94:1965;705-711.
28. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal. Biochem. 27:1969;502-522.
29. Pileblad E., Magnusson T., Fornstedt B. Reduction of brain glutathione by l-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum. J. Neurochem. Sci. 52:1989;978-980.
30. Bartus R. T., Flicker C., Dean R. L. Logical principles for the development of animal models of age-related memory impairments. Crook T., Ferris S., Bartus R. Behavioral assessment in geriatric psychopharmacology. 1983;263-299 Mark Powley Associates, New Canaan, CT.
31. Obata T., Yamanaka Y. Intracranial microdialysis of salicylic acid to detect hydroxyl radical generation by monoamine oxidase inhibitor in the rat. Neurosci. Lett. 188:1995;13-16.
32. +-evoked dopamine release from superfused striatal slices: Reversals by PBN or Trolox. Free Radic. Biol. Med. 20:1996;821-830.