Combined blockade of 5-HT3- and 5-HT4-serotonin receptors inhibits colonic functions in conscious rats and mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 1, 1997, Pages 284-290

  Nagakura, Yasunori ^a,b   Kontoh, Akiko ^a   Tokita, Kenichi ^a   Tomoi, Masaaki ^a   Shimomura, Kyoichi ^a   Kadowaki, Makoto ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b Fujikawa Pharmaceutical Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 2 (DIETHYLAMINO)ETHYL ESTER; 8 AMINO 7 CHLORO 1,4 BENZODIOXAN 5 CARBOXYLIC ACID 1 BUTYL 4 PIPERIDINYLMETHYL ESTER; FABESETRON; ONDANSETRON; RAMOSETRON; RECEPTOR SUBTYPE; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; COLON MOTILITY; CONTROLLED STUDY; DIARRHEA; DRUG SELECTIVITY; INTESTINE INNERVATION; INTESTINE SECRETION; INTESTINE TRANSIT TIME; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SEROTONINERGIC SYSTEM; SUBCUTANEOUS DRUG ADMINISTRATION;

4-AMINOBENZOIC ACID; ANIMALS; COLON; DIOXANES; MALE; MICE; ONDANSETRON; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN ANTAGONISTS;

EID: 0030910974     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. 3 receptor radioligand, in the cerebral cortex of rats. Eur. J. Pharmacol. 281: 37-42, 1995.
2. ANDERSON, J. V., COUPE, M. O., MORRIS, J. A., HODGSON, J. J. F. AND BLOOM, S. R.: Remission of symptoms in carcinoid syndrome with a new 5-hydroxy-tryptamine M receptor antagonist. Br. Med. J. 294: 1129, 1987.
3. 4 receptor antagonism by SB204070 inhibits 5-hydroxytryptophan-evoked defecation in mice. Br. J. Pharmacol. 110: 17P, 1993.
4. 3 receptor subtypes mediate cholera toxin-induced intestinal fluid secretion in the rat. Gastroenterology 99: 83-89, 1990.
5. 4 receptor function. J. Pharm. Pharmacol. 47: 219-222, 1995.
6. 4 receptor in the secretory response of human small intestine to 5-HT. Br. J. Pharmacol. 110: 927-928, 1993.
7. 4 receptors. Eur. J. Pharmacol. 205: 203-208, 1991.
8. BULBRING, E. AND CREMA, A.: The action of 5-hydroxytryptamine, 5-hydroxytryptophan and reserpine on intestinal peristalsis in anesthetized guinea-pigs. J. Physiol. 146: 29-53, 1959a.
9. BULBRING, E. AND CREMA, A.: The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa. J. Physiol. 146: 18-28, 1959b.
10. BULBRING, E. AND LIN, R. C. Y.: The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis; the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity. J. Physiol. 140: 381-407, 1958.
11. BUNCE, K. T., ELSWOOD, C. J. AND BALL, M. T.: Investigation of the 5-hydroxy-tryptamine receptor mechanism mediating the short-circuit current response in rat colon. Br. J. Pharmacol. 102: 811-816, 1991.
12. COOKE, H. J. AND REDDIX, R. A.: Neural regulation of intestinal electrolyte transport. In Physiology of the Gastrointestinal Tract. Ed. by L. R. Johnson, pp. 2083-2132, Raven Press, New York, 1994.
13. COOKE, H. J., WANG, Y.-Z., FRIELING, T. AND WOOD, J. D.: Neural 5-hydroxytryptamine receptors regulate chloride secretion in guinea pig distal colon. Am. J. Physiol. 261: G833-G840, 1991.
14. 4 receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea-pig isolated ileum. Br. J. Pharmacol. 110: 1572-1578, 1993.
15. 4 receptor. J. Pharmacol. Exp. Ther. 252: 1378-1386, 1990.
16. 4 receptor activation, Br. J. Pharmacol. 102: 563-564, 1991.
17. 3 receptors are membrane ion channels. Nature (Lond.) 339: 706-709, 1989.
18. 4) receptors. Br. J. Pharmacol. 108: 376-382, 1993.
19. 4 receptors in guinea-pig ascending colon. Eur. J. Pharmacol. 196: 149-155, 1991.
20. 4 receptors mediate the intestinal secretory response to 5-HT in rat in-vivo? J. Pharm. Pharmacol. 47: 213-218, 1995.
21. GERSHON, M. D., DRAKONTIDES, A. B. AND Ross, L. L.: Serotonin: Synthesis and release from the myenteric plexus of the mouae intestine. Science (Wash. DC) 149: 197-199, 1965.
22. GERSHON, M. D., A. L. KIRCHGESSNER AND P. R. WADE: Functional anatomy of the enteric nervous system. In Physiology of the Gastrointestinal Tract, ed bv L. R. Johnson, pp. 381-422. Raven Press, New York, 1994.
23. GUSTAFSEN, J., LENDORF, A., RASKOV, H. AND BOESBY, S.: Ketanserin versus placebo in carcinoid syndrome. Scand. J. Gastroenterol. 21: 816-818, 1986.
24. HANSEN, M. B., THORBOLL, J. E., CHRISTENSEN, P., BINDSLEV, N. AND SKADHAUOE, E.: Serotonin-induced short-circuit current in pig jejunum. J. Vet. Med. 41-110-120, 1994.
25. 4 receptor mediated stimulation of gastric emptying in rats. Naunyn-Schmiedeberg's Arch Pharmacol. 351: 589-595, 1995.
26. 4 receptor antagonist, on gastrointestinal functions. Gastroenterology 102: A739, 1992.
27. 4 receptor dual antagonist, on colonie function in vivo. J. Pharmacol. Exp. Ther. 266-74-80, 1993.
28. 4 receptor. Am. J. Physiol. 267: G357-G363, 1994.
29. 4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus. 345: 270-275, 1992.
30. MAWE, G. M., BRANCHEK, T. A. AND GERSHON, M. D.: Peripheral neural serotonin receptors: Identification and characterization with specific antagonists and agonists. Proc. Natl. Acad. Sci. U.S.A. 83: 9799-9803, 1986.
31. 3 receptor in stress-induced defecation. J. Pharmacol. Exp. Ther. 261: 297-303, 1992.
32. 4 receptors and gastric emptying in rodents. Jpn. J. Pharmacol. 69: 205-214, 1995.
33. 3 receptors in peristaltic reflex elicited by stroking the mucosa in the canine jejunum. J. Physiol. 471: 159-173, 1993.
34. 4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am. J. Physiol. 266: G230-G238, 1994.
35. PLATT, A. J., HEDDLE, R. M., RAKE, M. O. AND SMEDLEY, H.: Ondansetmn in carcinoid syndrome (letter), Lancet 339: 1416, 1992.
36. SCOTT, C. M., BUNCE, K. T. AND SPRAGGS, C. F.: Investigation of the 5-hydroxy-tryptamine receptor mediating the "maintained" short-circuit current response in guinea-pig ileal mucosa. Br. J. Pharmacol. 106: 877-882, 1992.
37. SIDHU, M. AND COOKE, H. J.: Role for 5-HT and Ach in submucosal reflexes mediating colonie secretion. Am. J. Physiol. 269: G346-G351, 1995.
38. VANNER, S. AND SURPRENANT, A.: Effects of 5-HT3 receptor antagonists on 5-HT and nicotinic depolarizations in guinea-pig submucosal neurones. Br. J. Pharmacol. 99: 840-844, 1990.
39. WADE, P. R., CHEN, J., JAFFE, B., KASSEM, I. S., BLAKELY, R. D. AND GERSHON, M. D.: Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J. Neurosci. 16: 2352-2364, 1996.
40. WADE, P. R., TAMIR, H., KIRCHGESSNER, A. L. AND GERSHUN, M. D.: Analysis of the role of 5-HT in the enteric nervous system using anti-idiotopic antibodies to 5-HT receptors. Am. J. Physiol, 266: G403-G416, 1994.
41. 4 receptor antagonist, on guinea-pig distal colon. Br. J. Pharmacol. 112: 789-794, 1994.
42. 4 receptor mediated contractions. Br. J. Pharmacol. 110: 1593-1599, 1993.
43. 4 receptors in ascending and descending reflexes to the circular muscle of guinea-pig small intestine, Br. J. Pharmacol. 112: 1095-1100, 1994.