Synthesis and cycloaddition reactions of pyrrole-fused 3-sulfolenes: A new versatile route to tetrabenzoporphyrins

Tetrahedron Letters

Volumn 38, Issue 20, 1997, Pages 3639-3642

  Vicente, Maria G H ^a   Tomé, Augusto C ^a   Walter, Andreas ^a   Cavaleiro, José A S ^a  

^a UNIVERSITY OF AVEIRO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPORPHYRIN DERIVATIVE; PHOTOSENSITIZING AGENT;

ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; MASS SPECTROMETRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS;

EID: 0030910795     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00689-8     Document Type: Article

References (30)

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28. Similar observation was made for pyrazole-fused 3-sulfolenes; see ref. 6b and references cited therein.
29. Typical procedure: Pyrrole 2a (50 mg; 0.22 mmol) and N-phenylmaleimide (76 mg; 2 equiv.) were heated in 1,2,4-trichlorobenzene (5 ml) at reflux, under nitrogen atmosphere, for 3 hours. After cooling to room temperature, the mixture was applied to the top of a column of silica; the trichlorobenzene and the excess of N-phenytmaleimide were eluted with petroleum ether: dichloromethane (7:3) and the adduct 3 (70 mg; 95 % yield) was then eluted with chloroform.
30. +).