Pharmacokinetic studies of lanoteplase, a novel tissue plasminogen activator (3) metabolism and excretion after a single bolus intravenous administration in rats

Pharmacometrics

Volumn 53, Issue 1, 1997, Pages 23-28

  Hata, Kimiyo ^a   Komoriya, Kazumi ^a   Takada, Naomi ^a   Kobayashi, Hayao ^a   Hayashi, Yujiro ^a  

^a SUNTORY LTD   (Japan)

Author keywords

(rat); Excretion; Lanoteplase; Metabolism; Novel tissue plasminogen activator

Indexed keywords

ALTEPLASE; LANOTEPLASE; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BOLUS INJECTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG TISSUE LEVEL; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; MALE; NONHUMAN; RADIOACTIVITY; RAT;

EID: 0030910691     PISSN: 03008533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

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2. (1997a): Plasminogen Activator, Lanoteplase (1) 53, 1-10.
3. (1997b): Plasminogen Activator, Lanoteplase (2) 53, 11-21.
4. (1995): Carperitide 49, 287-311.
5. Kuiper, J., Otter, M., Rijken, D.C. and Berkel, T.J.C. (1988): Characterization of the interaction in vivo of tissue-type plasminogen activator with liver cells, J. Biol. Chem., 263, 18220-18224.
6. Smerdrod, B. and Einarsson, M. (1990): Clearance of tissue plasminogen activator by mannose and galactose receptors in the liver, Thromb. Haemostas., 63, 60-66.
7. Stang, E., Roos, N., Schluter, M., Berg, T. and Krause, J. (1992): Evidence for carbohydrate-independent endocytosis of tissue-type plasminogen activator by liver cells, Biochem. J., 285, 799-804.