Formation of reactive oxygen species by spermatozoa from asthenospermic patients: Response to treatment with pentoxifylline

Journal of Urology

Volumn 157, Issue 6, 1997, Pages 2140-2146

  Okada, Hiroshi ^a   Tatsumi, Noboru ^a   Kanzaki, Masanori ^a   Fujisawa, Masato ^a   Arakawa, Soichi ^a   Kamidono, Sadao ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

infertility, male; pentoxifylline; reactive oxygen species; spermatozoa

Indexed keywords

FORMYLMETHIONYLLEUCYLPHENYLALANINE; PENTOXIFYLLINE; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE;

ARTICLE; ASTHENOSPERMIA; CHEMOLUMINESCENCE; CLINICAL ARTICLE; DRUG EFFICACY; FERTILIZATION; HUMAN; INFERTILITY THERAPY; MALE; MALE INFERTILITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0030910061     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)64697-4     Document Type: Article

References (26)

1. Aitken, R. J., Buckingham, D., West, K., Wu, F. C., Zikopoulos, K. and Richardson, D. W.: Differential contribution of leucocytes and spermatozoa to the generation of reactive oxygen species in the ejaculates of oligozoospermic patients and fertile donors. J. Reprod. Fertil., 94: 451, 1992.
2. Aitken, R. J. and Clarkson, J. S.: Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J. Reprod. Fertil., 81: 459, 1987.
3. D'Agata, R., Vicari, E., Moncada, M. L., Sidoti, G., Calogero, A. E., Fornito, M. C., Minacapilli, G., Mongioi, A. and Polosa, P.: Generation of reactive oxygen species in subgroup of infertile men. Int. J. Androl., 13: 344, 1990.
4. de Lamirande, E. and Gagnon, C.: Reactive oxygen species and human spermatozoa. I. Effects on the motility of intact spermatozoa and on sperm axonemas. J. Androl., 13: 368, 1992.
5. Alvarez, J. G., Touchstone, J. C., Storey, B. T. and Blasco, L.: Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa. Superoxide dismutase as major enzyme protectant against oxygen toxicity. J. Androl., 8: 338, 1987.
6. Iwasaki, A. and Gagnon, C.: Formation of reactive oxygen species in spermatozoa of infertile patients. Fertil. Steril., 57: 409, 1992.
7. Pang, S. C., Chan, P. J. and Lu, A.: Effect of pentoxifylline on sperm motility and hyperactivation in normozoospermic and normokinetic semen. Fertil. Steril., 60: 336, 1993.
8. Marrama, P., Baraghini, G. F., Carani, C., Celani, M. F., Giovenco, P., Grandi, F. and Montanini, V.: Further studies on the effect of pentoxifylline on sperm count and sperm motility in patients with idiopathic oligo-asthenozoospermia. Andrologia, 17: 612, 1985.
9. Yovich, J. M., Edirisinghe, W. R., Cummins, J. M. and Yovich, J. L.: Influence of pentoxifylline in severe male factor infertility. Fertil. Steril., 53: 715, 1990.
10. Biggers, J. D., Whitten, W. K. and Whittingham, D. G.: The culture of mouse embryos in vitro. In: Methods in Mammalian Embryology. Edited by J. C. Daniel, Jr. San Francisco: Freeman, pp. 86-116, 1971.
11. WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction, 3rd ed. New York: Cambridge University Press, 1992.
12. Makler, A.: The improved ten-micrometer chamber for rapid sperm count and motility evaluation. Fertil. Steril., 33: 337, 1980.
13. Mortimer, D., Serres, C., Mortimer, S. T. and Jouannet, P.: Influence of image sampling frequency on the perceived movement characteristics of progressively motile human spermatozoa. Gamete Res., 20: 313, 1988.
14. Burkman, L. J.: Discrimination between nonhyperactivated and classical hyperactivated motility patterns in human spermatozoa using computerized analysis. Fertil. Steril., 55: 363, 1991.
15. Lewis, S. E., Moohan, J. M. and Thompson, W.: Effect of pentoxifylline on the sperm motility in normospermic individuals using computer-assisted analysis. Fertil. Steril., 59: 418, 1993.
16. Yanagimachi, R., Yanaginachi, H. and Rogers, B. J.: The use of zona-free animal ova as a test-system for the assessment of the fertilizing capacity of human spermatozoa. Biol. Reprod., 15: 471, 1976.
17. Aitken, R. J. and Buckingham, D.: Enhanced detection of reactive oxygen species produced by human spermatozoa with 7-dimethyl amino-naphthalin-1, 2-dicarbonic acid hydrazide. Int. J. Androl., 15: 211, 1992.
18. Holland, M. K. and Storey, B. T.: Oxygen metabolism of mammalian spermatozoa. Generation of hydrogen peroxide by rabbit epididymal spermatozoa. Biochem. J., 198: 273, 1981.
19. Krausz, C., West, K., Buckingham, D. and Aitken, R. J.: Development of a technique for monitoring the contamination of human semen samples with leukocytes. Fertil. Steril., 57: 1317, 1992.
20. Niedel, J., Wilkinson, S. and Cuatrecasas, P.: Receptor-mediated uptake and degeneration of 1211-chemotactic peptide by human neutrophils. J. Biol., 254: 10700, 1979.
21. Jones, R., Mann, T. and Sherins, R.: Peroxidative breakdown of phospholipids in human spermatozoa, spermicidal properties of fatty acid peroxides, and protective action of seminal plasma. Fertil. Steril., 31: 531, 1979.
22. Ohyashiki, T., Ohtsuka, T. and Mohri, T.: Increase of molecular rigidity of the protein conformation in the intestinal brush-border membranes by lipid peroxidation. Biochem. Biophys. Acta, 93: 383, 1988.
23. Gavella, M. and Lipovac, V.: Pentoxifylline-mediated reduction of superoxide anion production by human spermatozoa. Andrologia, 24: 37, 1991.
24. Gavella, M., Lipovac, V. and Marotti, T.: Effect of pentoxifylline on superoxide anion production by sperm. Int. J. Androl., 14: 320, 1991.
25. Tesarik, J., Thébault, A. and Testart, J.: Effect of pentoxifylline on sperm movement characteristics in normozoospermic and asthenozoospermic specimens. Hum. Reprod., 7: 1257, 1992.
26. Tournaye, H., Van Steirteghem, A. C. and Devroey, P.: Pentoxifylline in idiopathic male-factor infertility: a review of its therapeutic efficacy after oral administration. Hum. Reprod., 9: 996, 1994.