The effects of nerve growth factor on spatial recent memory in aged rats persist after discontinuation of treatment

Journal of Neuroscience

Volumn 17, Issue 7, 1997, Pages 2543-2550

  Frick, Karyn M ^a   Price, Donald L ^b   Koliatsos, Vassilis E ^b   Markowska, Alicja L ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

aging; body weight; delayed non match to position; neurotrophins; water maze; working memory

Indexed keywords

NERVE GROWTH FACTOR;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SPATIAL MEMORY; TASK PERFORMANCE;

EID: 0030910003     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-07-02543.1997     Document Type: Article

References (14)

1. Bartus RT, Dean RL, Pontecorvo MJ, Flicker C (1985) The cholinergic hypothesis: a historical overview, current perspectives, and future directions. Ann NY Acad Sci 444:332-358.
2. Bondi MW, Salmon DP, Butters N (1994) Neuropsychological features of memory disorders in Alzheimer's disease. In: Alzheimer's disease (Terry RD, Katzman R, Bick KL, eds). New York: Raven.
3. Craik FIM (1977) Age differences in human memory. In: Handbook of the psychology of aging (Birren JE, Schale KW, eds), pp 384-420. New York: Van Nostrand Reinhold.
4. Damasio AR, Eslinger PJ, Damasio H, Van Hoesen GW, Cornell S (1985) Multimodal amnesiac syndrome following bilateral temporal and basal forebrain damage. Arch Neurol 42:252-259.
5. deToledo-Morrell L, Morrell F, Fleming S (1984) Age related deficits in spatial memory and hippocampal plasticity. Behav Neurosci 98:902-907.
6. Drachman DA, Leavitt J (1974) Human memory and the cholinergic system. A relationship to aging? Arch Neurol 30:113-121.
7. Fischer W, Wictorin K, Björklund A, Williams LR, Varos S, Gage FH (1987) Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329:65-68.
8. Vantini G, Fusco M, Schiavo N, Gradkowska M, Zaremba M, Leon A, Oderfeld-Nowak B (1990) Nerve growth factor induces a dosedependent and long-lasting increase of choline acetyltransferase activity in the septal area and hippocampus of uninjured rats. Acta Neurobiol Exp 50:323-332.
9. Williams LR (1991) Hypophagia is induced by intracerebroventricular administration of nerve growth factor. Exp Neurol 113:31-37.
10. Williams LR, Rylett RJ (1990) Exogenous nerve growth factor increases the activity of high-affinity choline uptake and choline acetyltransferase in brain of Fisher-344 male rats. J Neurochem 55:1042-1049.
11. Williams LR, Varon S, Peterson GM, Wictorin K, Fischer W, Björklund A, Gage FH (1986) Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection. Proc Natl Acad Sci USA 83:9231-9235.
12. Williams LR, Rylett RJ, Ingram DK, Joseph JA, Moises HC, Tang AH, Mervis RF (1993) Nerve growth factor affects the cholinergic neurochemistry and behavior of aged rats. Prog Brain Res 98:251-256.
13. Woolf CJ, Ma QP, Allchorne A, Poole S (1996) Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation. J Neurosci 16:2716-2723.
14. Yan Q, Matheson C, Sun J, Radeke MJ, Feinstein SC, Miller JA (1994) Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with trk receptor expression. Exp Neurol 127:23-36.