Pathogenesis and medical treatment of secondary hyperparathyroidism

Seminars in Surgical Oncology

Volumn 13, Issue 2, 1997, Pages 73-77

  Fukagawa, Masafumi ^a   Kurokawa, Kiyoshi ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKAI UNIVERSITY   (Japan)

Author keywords

calcitriol; calcitriol receptors; hyperparathyroidism; hyperplasia; parathyroid glands; parathyroid hormones; ultrasonography

Indexed keywords

CALCITRIOL;

ARTICLE; CHRONIC KIDNEY DISEASE; DISEASE ASSOCIATION; HUMAN; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROID HORMONE RELEASE; PARATHYROID HYPERPLASIA; PATHOGENESIS; PRIORITY JOURNAL; SECONDARY HYPERPARATHYROIDISM; VITAMIN INTAKE;

CALCITRIOL; DRUG RESISTANCE; HUMANS; HYPERPARATHYROIDISM, SECONDARY; HYPERPLASIA; KIDNEY FAILURE, CHRONIC; PARATHYROID GLANDS; PARATHYROID HORMONE; VITAMIN D;

EID: 0030909938     PISSN: 87560437     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2388(199703/04)13:2<73::AID-SSU2>3.0.CO;2-Z     Document Type: Article

References (36)

1. Malluche H, Faugere MC: Renal bone disease 1990: An unmet challenge for the nephrologist. [Review] Kidney Int 1990; 38:192-211.
2. Akizawa T, Fukagawa M, Koshikawa S, Kurokawa K: Recent progress in management of secondary hyperparathyroidism of chronic renal failure. Curr Opin Nephrol Hypertens 1993;2:558-565.
3. Coburn JW, Llach F: Renal osteodystrophy. In Narins RG (ed): "Maxwell and Kleeman's Clinical Disorders of Fluid and Electrolyte Metabolism." 5th ed. New York: McGraw Hill, 1994, 1299-1377.
4. Felsenfeld AJ, Llach F: Parathyroid function in chronic renal failure [editorial]. Kidney Int 1993;43:771-789.
5. Kremer R, Boliver I, Goltzman D, Hendy GN: Influence of calcium and 1,25-dihydroxycholecalciferol on proliferation and proto-oncogene expression in primary cultures of bovine parathyroid cells. Endocrinology 1989;125:935-941.
6. 2+ sensing receptor from bovine parathyroid. Nature 1993;366:575-580.
7. 3 inhibits parathyroid cell proliferation in experimental uremia. Kidney Int 1989;35:1049-1056.
8. Slatopolsky EA, Weerts C, Thielan J, et al.: Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxycholecalciferol in uremic patients. J Clin Invest 1984;74:2136-2143.
9. Delmez JA, Tindira C, Grooms P, et al.: Parathyroid hormone suppression by intravenous 1,25-dihydroxyvitamin D. A role for increased sensitivity to calcium. J Clin Invest 1989; 83:1349-1355.
10. Fukagawa M, Okazaki R, Takano K, et al.: Regression of parathyroid hyperplasia by calcitriol-pulse therapy in patients on long-term dialysis. N Engl J Med 1990;323:421-422.
11. Fukagawa M, Kaname S, Igarashi T, et al : Regulation of parathyroid hormone synthesis in chronic renal failure in rats. Kidney Int 1991;39:874-881.
12. 3 in the parathyroid glands of patients with renal failure. N Engl J Med 1987;316:1573-1577.
13. 2D receptors are decreased in parathyroid glands from chronically uremic dogs. Kidney Int 1989;35:19-23.
14. 3 in the parathyroid in vivo. J Clin Invest 1990;86:1968-1975.
15. Hsu CH, Patel SR, Young EW, Vanholder R: The biological action of calcitriol in renal failure. [Editorial] [Review] Kidney Int 1994;46:605-612.
16. Lopez-Hilker S, Dusso AS, Rapp NS, et al.: Phosphorus restriction reverses secondary hyperparathyroidism in uremia independent of changes in calcium and calcitriol. Am J Physiol 1990;259(3 Pt 2):F432-437.
17. Yi H, Fukagawa M, Yamato H, et al.: Prevention of enhanced parathyroid hormone secretion, synthesis and hyperplasia by mild dietary phosphorus restriction in early chronic renal failure in rats: Possible direct role of phosphorus. Nephron 1995;70:242-248.
18. Slatopolsky E, Finch J, Denda M, et al.: Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro. J Clin Invest 1996;96:7534-2540.
19. Almaden Y, Canalejo A, Hernandez A, et al.: Direct effect of phosphorus on PTH secretion from whole rat parathyroid glands in vitro. J Bone Miner Res 1996;7:970-976.
20. Sriussadaporn S, Wong MS, Pike JW, Favus MJ: Tissue specificity and mechanism of vitamin D receptor up-regulation during dietary phosphorus restriction in the rat. J Bone Miner Res 1995;10:271-280.
21. Ureña P, Kubrusly M, Mannstadt M, et al.: The renal PTH/PTHrP receptor is down-regulated in rats with chronic renal failure. Kidney Int 1994;45.605-611.
22. Fukagawa M, Kitaoka M, Yi H, et al.: Serial evaluation of parathyroid size by ultrasonography is another useful marker for the long-term prognosis of calcitriol pulse therapy in chronic dialysis patients. Nephron 1994;68:221-228.
23. Tominaga Y, Takagi H: Molecular genetics of hyperparathyroid disease. Curr Opin Nephrol Hypertens 1996;5:336-341.
24. 3 receptor density is associated with a more severe form of a parathyroid hyperplasia in chronic uremic patients. J Clin Invest 1993;92:1436-1443.
25. Drüėke TB: The pathogenesis of parathyroid gland hyperplasia in chronic renal failure. [Review] Kidney Int 1995;48:259-272.
26. Falchetti A, Bale AE, Amorosi A, et al.: Progression of uremic hyperparathyroidism involves allelic loss on chromosome 11. J Clin Endocrinol Metab 1993;76:139-144.
27. Quarles LD, Lobaugh B, Murphy G: Intact parathyroid hormone overestimates the presence and severity of parathyroid-mediated osseous abnormalities in uremia. J Clin Endocrinol Metab 1992;75:145-150.
28. Hercz G, Pei Y, Greenwood C, et al.: Aplastic osteodystrophy without aluminum: The role of "suppressed" parathyroid function. Kidney Int 1993;44:860-866.
29. Goodman WG, Ramirez JA, Belin TR, et al.: Development of adynamic bone in patients with secondary hyperparathyroidism after intermittent calcitriol therapy. Kidney Int 1994;46:1160-1166.
30. Kurokawa K, Akizawa T, Suzuki M, et al.: Effect of 22-oxacalcitriol on hyperparathyroidism of dialysis patients: results of a preliminary study. Nephrol Dial Transplant 1996;11:121-129.
31. Fox J, Hadfield S, Petty BA, et al.: NPS R-568 inhibits parathyroid hormone secretion and stimulates calcitonin secretion in hyperparathyroid rats with chronic renal failure [abstract]. J Am Soc Nephrol 1993;4:719.
32. Giangrande A, Castiglioni A, Sorbiati L, Allaria P: Ultrasound guided percutaneous fine needle ethanol injection into parathyroid glands in secondary hyperparathyroidism. Nephrol Dial Transplant 1992;7:412-421.
33. Kitaoka M, Fukagawa M, Ogata E, Kurokawa K: Reduction of functioning parathyroid cell mass by ethanol injection in chronic dialysis patients. Kidney Int 1994;46:1110-1117.
34. Kitaoka M, Fukagawa M, Kurokawa K: Direct injection of calcitriol into parathyroid hyperplasia in chronic dialysis patients with severe parathyroid hyperfunction Nephrology 1995;1:563-568.
35. 3 ameliorates the high-turnover bone diseases without suppression parathyroid function in chronic renal failure in rats. Nephrology 1996;2:361-366.
36. Kazama JJ, Fukagawa M, Yi H, et al.: Fine structure of trabecular bone in uremic rats analyzed by microfocus X-ray imaging. [Abst] J Bone Miner Res 1996,11:S490.