Paternal transmission of the mouse T(hp) mutation is lethal in some genetic backgrounds

Developmental Genetics

Volumn 20, Issue 1, 1997, Pages 23-28

  Rogers, Ian ^b   Okano, Kazuhiro ^b   Varmuza, Sue ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NONE

Author keywords

Igf2r; paternal lethal; T(hp); Tme

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME 17; CONTROLLED STUDY; EMBRYO; FEMALE; FETUS; GENE DOSAGE; GENE LOCUS; GENE MUTATION; GENOME IMPRINTING; INBRED STRAIN; LETHAL GENE; MALE; NEWBORN; NONHUMAN; PATERNITY; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; PROGENY; VERTICAL TRANSMISSION;

ABNORMALITIES, MULTIPLE; ANIMALS; CHROMOSOME DELETION; CHROMOSOME MAPPING; CROSSES, GENETIC; EDEMA; EMBRYONIC AND FETAL DEVELOPMENT; EPISTASIS, GENETIC; FEMALE; FETAL DEATH; GENES, LETHAL; GENOMIC IMPRINTING; GENOTYPE; GESTATIONAL AGE; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEURAL TUBE DEFECTS; PHENOTYPE; RECEPTOR, IGF TYPE 2; TAIL;

ANIMALIA;

EID: 0030909724     PISSN: 0192253X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6408(1997)20:1<23::AID-DVG3>3.0.CO;2-B     Document Type: Article

References (18)

1. hp deletion. J Heredity 82:351-353.
2. Artzt K, Cookingham J, Bennett D (1987): A new mutation (t-int) interacts with the mutations of the mouse T/t complex that affect the tail. Genetics 116:601-605.
3. Artzt K, Barlow D, Dove WF, Fischer-Lindahl K, Klein J, Lyon MF, Silver L (1991): Maps of mouse chromosome 17: First report. Mammalian Genome 1:5-29.
4. Barlow DP, Stoger R, Hermann BG, Schweifer N (1991): The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature 349:84-87.
5. Bennett D (1975): The T-Locus of the mouse. Cell 6:414-454.
6. Filson AJ, Louvi A, Efstratiadis A, Robertson EJ (1993): Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf-2r, two recprocally imprinted genes. Development 118:731-736.
7. Forejt J, Gregorova S (1992): Genetic analysis of genomic imprinting: An imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus. Cell 70:443-450.
8. Forejt J, Gregorova S, Landikova M, Capkova J, Silver LM (1995): Genetic variations in parental imprinting on mouse chromosome 17. In Ohlsson R, Hall K, Ritzen M (eds): "Genomic Imprinting: Causes and Consequences." New York: Cambridge University Press, pp 29-45.
9. Frankel WN (1995): Taking stock of complex trait genetics in mice. Trends Gen 11:471-477.
10. Johnson DR (1974): Hairpin-tail: A case of post reductional gene action in the mouse egg? Genetics 76:795-805.
11. hp) mutation in the mouse. Genetic Res Cambridge 24:204-213.
12. Lau MMH, Stewart CEH, Liu Z, Bhatt H, Rotwein P, Stewart CL (1994): Loss of the IGF2 / cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev 8:2953-2963.
13. Rennebeck GM, Lader E, Chen Q, Bohm RA, Cai ZS, Faust C, Magnuson T, Pease LR, Artzt K (1995): Is there a Brachyury the second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol 172:206-217.
14. Schimenti J, Void L, Socolow D, Silver L (1987): An unstable family of large DNA elements in the center of the mouse t complex. J Mol Biol 194:583-594.
15. Tsai JY, Silver L (1991): Escape from genomic imprinting at the mouse T-associated maternal effect (Tme) locus. Genetics 129:1159-1166.
16. ae5) in the mouse on the lymphoid system and reproduction. J. Embry Exp Morph 36:443-451.
17. Wang ZQ, Fung MR, Barlow DP, Wagner EF (1994): Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/ Mpr gene. Nature 372:464-467.
18. Winking H, Silver L (1984): Characterization of a recombinant mouse T haplotype that expresses a dominant lethal maternal effect. Genetics 108:1013-1020.