Essential lysine residues in the N-terminal and the C-terminal domain of human adenylate kinase interact with adenine nucleotides as found by site- directed random mutagenesis

Biochemistry

Volumn 36, Issue 13, 1997, Pages 4027-4033

  Ayabe, Takanori ^a   Takenaka, Hitoshi ^a,e   Takenaka, Osamu ^b   Sumida, Michihiro ^c   Maruyama, Hideharu ^f   Onitsuka, Toshio ^a   Shibata, Koichiro ^a   Uesugi, Seiichi ^d   Hamada, Minoru ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d YOKOHAMA NATIONAL UNIVERSITY   (Japan)

^e KYORIN UNIVERSITY   (Japan)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE MAGNESIUM; ADENYLATE KINASE; LYSINE; MUTANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HUMAN; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEADY STATE;

ADENINE NUCLEOTIDES; ADENYLATE KINASE; BINDING SITES; DNA PRIMERS; HUMANS; KINETICS; LYSINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0030909320     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961796a     Document Type: Article

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