New inotropic agents: Milrinone analogs

General Pharmacology

Volumn 28, Issue 5, 1997, Pages 781-788

  Dorigo, P ^a   Froccarollo, D ^a   Gaion, R M ^a   Santostasi, G ^a   Borea, P A ^b   Floreani, M ^a   Mosti, L ^c   Maragno, I ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

adenosine; guinea pig atria; Milrinone analogs; phosphodiesterase III

Indexed keywords

3 ACETYL 6 PHENYL 2(1H) PYRIDONE; 3 ACETYL 7 METHYL 7,8 DIHYDRO 2,5(1H,6H) QUINOLINONE; 3 ACETYL 7,8 DIHYDRO 7 METHYL 2,5(1H,6H) QUINOLINEDIONE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE DEAMINASE; BETA ADRENERGIC RECEPTOR; CYCLOHEXYLADENOSINE; INOTROPIC AGENT; MILRINONE; PHENYLISOPROPYLADENOSINE; PHOSPHODIESTERASE; PROPRANOLOL; RESERPINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; CARDIOVASCULAR EFFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; GUINEA PIG; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADENOSINE; ADENOSINE DEAMINASE; ANIMALS; ATRIAL FUNCTION; BINDING, COMPETITIVE; CARDIOTONIC AGENTS; ELECTRIC STIMULATION; GUINEA PIGS; HEART ATRIA; MALE; MILRINONE; MYOCARDIAL CONTRACTION; MYOCARDIUM; PHENYLISOPROPYLADENOSINE; PHOSPHODIESTERASE INHIBITORS; PROPRANOLOL; PYRIDONES; QUINOLONES; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, PURINERGIC P1; RESERPINE;

EID: 0030909302     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00271-6     Document Type: Article

References (27)

1. Belardinelli L., West A., Crampton R. and Berne R. M. (1983) Chronotropic and dromotropic actions of adenosine. In Regulatory Function of Adenosine (Edited by Berne R. M., Tall T.W. and Rubio E.) pp. 378-398. Martinus Nijhoff, Boston.
2. 3H phenylxanthine. Proc. Natl. Acad. Sci. USA, 77, 5547-5551.
3. Dorigo P., Fraccarollo D., Santostasi G., Gaion R. M., Maragno L., Floreani M., Carpenedo F., Jester M., Mosti L. and Schenone P. (1994) Pharmacological characterization of a new milrinone analogue. Il Farmaco 49, 19-23.
4. Dorigo P. and Maragno I. (1986) Interaction of amrinone with endogenous adenosine in guinea-pig atria. Br. J. Pharmac. 32, 625-629.
5. Dorigo P., Gaion R. M. and Maragno I. (1990) Involvement of purine compounds in the inotropic action of milrinone. Cardiovasc. Drugs Ther. 4, 509-514.
6. Dorigo P., Gaion R. M., Betluco P., Borea P. A., Guerra L., Mosti L., Floreani M. and Carpenedo F. (1992) Antagonism towards endogenous adenosine and inhibition of cGI-PDE in the cardiac effects of amrinone, milrinone and related analogues. Gen. Pharmac. 23, 535-541.
7. Dorigo P., Gaion R. M., Belluco P., Fraccarollo D., Maragno I., Bombieri G., Benetollo F., Mosti L. and Orsini F. ( 1993) A pharmacological, crystallographic, and quantum chemical study of new inotropic agents. J. Med. Chem. 36, 2475-2484.
8. Dorigo P., Gaion R. M., Belluco P., Mosti L., Borea P. A. and Maragno I. (1991) An analysis of the mechanism of the inotropic action of some milrinone analogues in guinea-pig isolated atria. Br. J. Pharmac. 104, 867-872.
9. Earl C. Q., Linden J. and Weglicki W. B. (1986) Biochemical mechanism for the inotropic effect of the cardiotonic drug milrinone. J. Cardiovasc. Pharmac. 8, 864-871.
10. Endoh M., Maruyama M. and Taira N. (1983) Adenosine-induced changes in role of beating and cyclic nucleotide levels in rat atria: modifications by islet-activating protein. In Physiology and Pharmacology of Adenine Derivatives (Edited by Daly J. W., Kuroda Y., Phillis J. W. and Schmizu H. V. M.) pp. 127-141. Raven Press, New York.
11. Feldman M. D., Copelas L., Gwanthmey J. K., Phillips P., Warren S. E., Schoen F. J., Grossman W. and Morgan J. P. (1987) Deficient production of cyclic AMP: pharmacological evidence of an important cause of contractile dysfunction in patients with end-stage heart failure. Circulation. 75, 331-339.
12. Itoh S., Mori T., Tominaga M., Shikawa M., Koga K. and Yabu-Uchi Y, ( 1995) Differential effects of OPC-18790, amrinone and dobutamine on cardiac function and energy metabolism in the guinea-pig isolated ishaemic heart. Br. J. Pharmac. 114, 1090-1096.
13. 3H]adenosine. Eur.J. Pharmac. 73, 109-113.
14. Lowry O. H., Rosebrough N. J., Farr A. L. and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
15. Lubbe W. F., Podzuwett T. and Opie L. H. (1992) Potential arrhyrhmogenic role of cyclic monophosphate (AMP) and cytosolic calcium overload: implications for prophylactic effects of beta-blockers in myocardial infarction and proarrhythmic effects of phosphodiesterase inhibitors. J. Am. Coll. Cardiol. 19, 1622-1655.
16. Newman W. H., Grossman S. J., Frankis M. B. and Webb J. G. (1984) Increase myocardial adenosine release in heart failure. J. Mol. Cell. Cardiol. 16, 577-580.
17. Packer M. (1988) Vasodilator and inotropic drugs for the treatment of chronic heart failure: distinguishing type from hope. J. Am. Coll. Cardiol. 12, 1299-1317.
18. Packer M., Carver J. R., Rodeheffer R. J., Ivanhoe R. J., Di Bianco R., Zeldis S. M., Hendrix G. H., Bommer W. J., Elkayam D., Kukin M. L., Mallis G. J., Sollano J. A., Shannon J., Tandon P. K. and De Metes D. L. (1991) Effect of oral milrinone on mortality in severe chronic heart failure. N. Engl. J. Med. 325, 1468-1475.
19. Parson W. J., Ramkumar V. and Stiles G. L. (1988) The new cardiotonic agent sulmazole is an Al adenosine receptor antagonist and functionally blocks the inhibitory regulator Gi. Mol. Pharmac. 33, 441-448.
20. Pelleg A., Mitsouka T. and Michelson E. L. (1987) Adenosine mediates the negative chronotropic action of adenosine-5′-triphosphate in the canine sinus node. J. Pharmacol. Exp. Ther. 242, 791-795.
21. Schmitz W., Brukner R., Häckbarth J., Meyer W. and Scholz H. (1981) Evidence against a role of cAMP and cGMP in the inotropic effects of adenosine and adenosine analogs in guinea-pig atria. Naunyn-Schmiedeberg's Arch. Pharmac. 316, R34.
22. Schutz W. and Tuiste E. (1981) Evidence against adenylate cyclase-coupled adenosine receptors in the guinea-pig heart. Eur. J. Pharmac. 76, 285-288.
23. Temma K., Akera T., Brody T. M. and Mannian A. A. (1977) Hydroxylated chloropromazine metabolites: positive inotropic action and the release of catecholamines. Molec. Pharmac. 13, 1076-1085.
24. Thompson W. J., Brooker G. and Appleman M. M. (1974) Assay of cyclic nucleotide phosphodiesterase with radioactive substrates. Meth. Enzymol. 38, 205-214.
25. Thompson W. J., Terasaki W. L., Epstein P. M. and Strada S. J. (1979) Assay of cyclic nucleotide phosphodiesterase and resolution of multiple molecular forms of the enzyme. Adv. Cyclic Nucl. Res. 10, 69-72.
26. Ungerer M., Bohm M., Schwinger R. H. G. and Erdman E. (1990) Antagonism of novel inotropic agents at A1 adenosine receptors and m-cholinoceptors in human myocardium. Naunyn-Schmiedebergs Arch. Pharmac. 341, 577-585.
27. Weishaar R. E., Kobilarz-Singer D. L., Steffen R. P. and Kaplan A. R. (1987) Subclasses of cyclic AMP specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility. Curr. Res. 61, 539-547.