Synthesis, stability and anticonvulsant activity of two new GABA prodrugs

Pharmazie

Volumn 52, Issue 4, 1997, Pages 272-276

  Palagiano, F ^a   Bonina, F P ^b   Montenegro, L ^b   Biondi, A ^c   Sorrentino, L ^a   Capasso, A ^a   De Caprariis, P ^d  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

^d UNIVERSITY OF SASSARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3,4 DIHYDRO 2,4 DIOXO 2H 1,3 BENZOXAZIN 3 YL)BUTYRIC ACID; 4 AMINOBUTYRIC ACID DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STABILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; PLASMA;

ANIMALS; ANTICONVULSANTS; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GAMMA-AMINOBUTYRIC ACID; HALF-LIFE; HYDROLYSIS; INJECTIONS, INTRAPERITONEAL; MALE; MICE; OXAZINES; PRODRUGS; SOLUBILITY;

EID: 0030909207     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Enna, S. J.; Stern, L. Z.; Wastek, G. J.; Yakamura, H. I.: Life Sci. 20, 205 (1977)
2. Bakay, R. A. E.; Harris, A. B.: Brain Res. 206, 387 (1981)
3. Nishino, N.; Fujiwara, H.; Noguchi-Kuno, S. A.; Tanaka, C.: Jpn. J. Pharmacol. 48, 331 (1988)
4. Meldrum, B. S.; Horton, R. W.; in Harris, P.; Mawdsley, C. (Eds.): Epilepsy, p. 55, Churchill Livingston, Edinburg 1974
5. Shashoua, V. E.; Jacob, J. N.; Ridge, R.; Campbell, A.; Baldessarrini, R. J.: J. Med. Chem. 27, 659 (1984)
6. Madrid, Y.; Feigenbaum Langer, L.; Brem, H.; Langer, R.: Adv. Pharmacol. 22, 299 (1991)
7. Bianchi, M.; Deana, R.; Quadro, G.; Mourier, G.; Galzigna, L.: Biochem. Pharmacol. 32, 1093 (1983)
8. Jacob, J. N.; Shashoua, V. E.; Campbell, A.; Baldessarrini, R. J.: J. Med. Chem. 28, 106 (1985)
9. Jacob, J. N.; Hesse, G. W.; Shashoua, V. E.: J. Med. Chem. 33, 733 (1990)
10. Deverre, J. R.; Loiseau, P.; Couvreur, P.; Letourneux, Y.; Gayral, P.; Benoit, J. P.: J. Pharm. Pharmacol. 41, 191 (1989)
11. Lambert, D. M.; Neuvens, L.; Mergen, F.; Gallez, B.; Poupaert, J. H.; Ghysel-Burton, J.; Maloteaux, J. M.; Dumont, P.: J. Pharm. Pharmacol. 45, 186 (1993)
12. Matsuyama, K.; Yamashita, C.; Noda, A.; Goto, S.; Noda, H.; Ichimaru, Y.; Gomita, Y.: Chem. Pharm. Bull. 32, 4089 (1984)
13. Galzigna, L.; Garbin, L.; Bianchi, M.; Marzotto, A.: Arch. Int. Pharmacodyn. 235, 73 (1978)
14. Bodor, N. S.: U.S: Patent US 482850, 25 Apr., 1989
15. Kahns, A. H.; Bundgaard, H.: Acta Pharm. Nord. 3, 45 (1991)
16. Kahns, A. H.; Møss, J.; Bundgaard, H.: Int. J. Pharm. 78, 199 (1992)
17. Fieser, L. F.; Fieser, M.: Reagents for Organic Synthesis, vol. 1, p. 114, John Wiley & Sons, Inc., New York 1967
18. Bonina, F. P.; Montenegro, L.; de Caprariis, P.; Bousquet, E.; Tirendi, S.: Int. J. Pharm. 77, 21 (1991)
19. Sloan, K. B.: Adv. Drug Del. Rev. 3, 67 (1989)
20. Mishima, M.; Kobayashi, S.; Abe, S.; Yamato, C.: Xenobiotica 20, 135 (1990)
21. Bonina, F. P., Montenegro, L.; Trapani, G.; Franco, M.; Liso, G.: Int. J. Pharm. 124, 45 (1995)