High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT(1A) receptors

Pharmacology Biochemistry and Behavior

Volumn 56, Issue 3, 1997, Pages 481-486

  Canto De Souza, Azair ^b   Nunes De Souza, Ricardo L ^a   Pelá, Irene R ^b   Graeff, Frederico G ^b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b NONE

Author keywords

5 HT(1A) agonists; analgesia; diazepam; naloxone; social conflict; Swiss albino mice

Indexed keywords

4 DIPROPYLAMINO 1,3,4,5 TETRAHYDRO 6 METHOXYBENZ[CD]INDOLE; BENZODIAZEPINE RECEPTOR; DIAZEPAM; GEPIRONE; MORPHINE; NALOXONE; SEROTONIN 1A RECEPTOR; SEROTONIN AGONIST;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SOCIAL BEHAVIOR; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION;

ANALGESIA; ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; CONFLICT (PSYCHOLOGY); DIAZEPAM; INDOLES; MALE; MICE; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; PAIN; PAIN MEASUREMENT; PYRIMIDINES; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS;

ANIMALIA;

EID: 0030909076     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00246-8     Document Type: Article

References (38)

1. Amir, S.; Brown, Z. W.; Amit, Z. The role of endorphins in stress: Evidence and speculations. Neurosci. Biobehav. Rev. 4:77-86; 1980.
2. Bolles, R. C.; Fanselow, M. S. A perceptual-defensive-recuperative model of fear and pain. Behav. Brain Sci. 3:291-322; 1980.
3. Clatworthy, A.; Williams, J. H.; Barasi, S. Intrathecal 5-hydroxytryptamine and electrical stimulation of the nucleus raphe magnus in rats both reduce the antinociceptive potency of intratecally administered noradrenaline. Brain Res. 455:300-306; 1988.
4. Deakin, J. F. W.; Graeff, F. G. 5-HT and mechanisms of defence. J. Psychopharmacol. 5(4):305-315; 1991.
5. 1A receptors in anxiety. In: Briley, M.; File, S. E , eds. New concepts in anxiety. London: MacMillan Press; 1991:94-129.
6. Fanselow, M. S. Conditioned fear-induced opiate analgesia: A competing motivational state theory of stress analgesia. Ann. NY. Academic. Sci. 467:40-54; 1986.
7. Frischknecht, H.-R.; Siegfried, B. Relationship between behavioral and nociceptive changes in attacked mice: Effects of opiate antagonists. Psychopharmacology 97:160-162; 1989.
8. Frischknecht, H.-R.; Siegfried, B.; Waser, P. G. Opioids and behavior: Genetic aspects. Experientia 44:473-481; 1988.
9. Hüston, J. P.; Bures, J. Innate and motivated behavior. In: Bures, J.; Buresova, O.; Hüston, J. P. Techniques and basic experiments for the study of brain and behavior. Amsterdam, Holland: Elsevier; 1983:77-126.
10. Hylden, J. L. K.; Wilcox, G. L. Intrathecal serotonin in mice. Analgesia and inhibition of spinal action of substance P. Life Sci. 33:789-795; 1983.
11. Larsen, J. J.; Avnt, J. Spinal 5-HT orNA uptake inhibition potentiates supraspinal morphine antinociception in rats. Acta. Pharmacol. Toxicol. 54:72-75; 1984.
12. Miczek, K. A.; Thompson, M. L. Analgesia resulting from defeat in a social confrontation: The role of endogenous opioids in brain. In: Bandler, R., ed. Modulation of sensorimotor activity during alterations in behavioral states. New York: A. R. Liss; 1984:431-456.
13. Miczek, K. A.; Thompson, M. L.; Shuster, L. Opioid-like analgesia in defeated mice. Science 215:1520-1522; 1982.
14. Murphy, R. M.; Zemlan, F. P. Differential effects of substance P on serotonin-modulated spinal nociceptive reflexes. Psychopharmacology 93:118-121; 1987.
15. Rodgers, R. J.; Hendrie, C. A. Social conflict activates status-dependent endogenous analgesic or hyperalgesic mechanisms in male mice: Effects of naloxone on nociception and behaviour. Physiol. Behav. 30:775-780; 1983.
16. Rodgers, R. J.; Randall, J. I. Social conflict analgesia: Studies on naloxone antagonism and morphine cross-tolerance in male DBA/2 mice. Pharmacol. Biochem. Behav. 23:883-887; 1985.
17. Rodgers, R. J.; Randall, J. I. Acute non-opioid analgesia in defeated male mice. Physiol. Behav. 36:947-950; 1986.
18. Rodgers, R. J.; Randall, J. I. Social conflict analgesia: Inhibition of early non-opioid component by diazepam or flumazenil fails to affect appearance of late opioid component. Brain Res. Bull. 19:141-144; 1987a.
19. Rodgers, R. J.; Randall, J. I. Benzodiazepine ligands, nociception and defeat analgesia in male mice. Psychopharmacol. (Berlin) 91:305-315; 1987b.
20. Rodgers, R. J.; Randall, J. I Are the analgesic effects of social defeat mediated by benzodiazepine receptors? Physiol. Behav. 41:279-289; 1987c.
21. Rodgers, R. J.; Randall, J. I. Potent inhibition of non-opioid defeat analgesia in male mice by benzodiazepine antagonist Ro 15-3505. Physiol. Behav. 42:461-464; 1988a.
22. Rodgers, R. J.; Randall, J. I. Blockade of non-opioid analgesia in intruder mice by selective neuronal and non-neuronal benzodiazepine recognition site ligands. Psychopharmacol. (Berlin) 96:45-54; 1988b.
23. Rodgers, R. J.; Randall, J. I. Environmentally induced analgesia: Situational factors, mechanisms and significance. In: Rodgers, R. J.; Cooper, S. J., eds. Endorphins, opiates and behavioural processes. Chichester: John Wiley; 1988c:107-142.
24. 1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), inhibits non-opioid analgesia in defeated mice: Influence of route of administration. Psychopharmacol. (Berlin) 97:163-165; 1989a.
25. 1A anxiolytics, buspirone, gepirone and ipsapirone. Psychopharmacol. 99:374-380; 1989b.
26. 1A receptor agonist. Eur. J. Pharmacol. 182:581-585; 1990.
27. Schmauss, C.; Hammond, D. L.; Ochi, J. W.; Yaksh, T. L. Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord. Eur. J. Pharmacol. 90:349-357; 1983.
28. Siegfried, B.; Frischknecht, H.-R. Place avoidance learning and stress-induced analgesia in the attacked mouse: Role of endogenous opioids. Neural Biol. 52:95-107; 1989.
29. Siegfried, B.; Frischknecht, H.-R.; Riggio, G.; Waser, P. G. Long-term analgesic reaction in attacked mice. Behav. Neurosci. 101:797-805; 1987a.
30. Siegfried, B.; Frischknecht, H.-R.; Riggio, G.; Waser, P. G. Preexposure to a nonaggressive opponent prevents low-intensity, social conflict analgesia in mice. Behav. Neurosci. 101:423-426; 1987b.
31. Siegfried, B.; Frischknecht, H.-R.; Nunes de Souza, R. L. An ethological model for the study of activation and interaction of pain, memory and defensive systems in the attacked mouse. Role of endogenous opioids. Neurosci. Biobehav. Rev. 14:481-490; 1990.
32. Siegfried, B.; Frischknecht, H.-R.; Waser, P. G. Defeat, learned submissiveness, and analgesia: Effect of genotype. Behav. Neural Biol. 42:91-97; 1984.
33. Teskey, G. C.; Kavaliers, M. Aggression, defeat and opioid activation in mice: Influences of social factors, size and territory. Behav. Brain Res. 23:77-84; 1987.
34. Teskey, G. C.; Kavaliers, M.; Hirst, M. Social conflict activates opioid analgesic and ingestive behaviors in male mice. Life Sci. 35:303-315; 1984.
35. Wang, J. K. Antinociceptive effect of intrathecally administered serotonin. Anesthesiol. 271:269-271; 1977.
36. Yaksh, T. L.; Wilson, P. R. Spinal serotonin terminal system mediates antinociception. J. Pharmacol. Exp. Therap. 208:446-453; 1979.
37. Zemlan, F. P.; Kow, L. M.; Pfaff, D. W. Spinal serotonin (5-HT) receptors subtypes and nociception. J. Pharmacol. Exp. Therap. 226:477-485; 1983.
38. Zifa, E.; Fillion, G. 5-Hydroxytryptamine receptors. Pharmacol. Rev. 44:401-458; 1992.