Enhanced binding of advanced glycation endproducts (AGE) by the ApoE4 isoform links the mechanism of plaque deposition in Alzheimer's disease

Neuroscience Letters

Volumn 226, Issue 3, 1997, Pages 155-158

  Li, Yong Ming ^a   Dickson, Dennis W ^b  

^a PICOWER INST FOR MEDICAL RESEARCH   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

advanced glycation endproducts; Alzheimer's disease; apolipoprotein E

Indexed keywords

APOLIPOPROTEIN E;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLYCOSYLATION; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; SENILE PLAQUE;

ALLELES; ALZHEIMER DISEASE; AMYLOID; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BLOTTING, WESTERN; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; PROTEIN BINDING; RISK FACTORS;

EID: 0030908734     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00266-8     Document Type: Article

References (17)

1. Dickson, D.W., Sinicropi, S., Yen, S., Ko, L., Mattiace, L.A., Bucala, R. and Vlassara, H., Glycation and microglial reaction in lesions of Alzheimer's disease, Neurobiol. Aging, 17 (1996) 733-743.
2. Goedert, M., Strittmatter, W.J. and Roses, A.D., Alzheimer's disease, risky apolipoprotein in brain, Nature, 372 (1994) 45-46.
3. Huang, D.Y., Goedert, M., Jakes, R., Weisgraber, K.H., Garner, C.C., Saunders, A.M., Pericak-Vance, M.A., Schmechel, D.E., Roses, A.D. and Strittmatter, W.J., Isoform-specific interactions of apolipoprotein e with the microtubule-associated protein MAP2c: implications for Alzheimer's disease, Neurosci. Lett., 182 (1994) 55-58.
4. Ledesma, M.D., Bonay, P. and Avila, J., Tau protein from Alzheimer's disease patients is glycated at its tubulin-binding domain, J. Neurochem., 65 (1995) 1658-1664.
5. Ledesma, M.D., Bonay, P., Colaco, C. and Avila, J., Analysis of microtubule-associated protein tau glycation in paired helical filaments, J. Biol. Chem., 269 (1994) 21614-21619.
6. Li, Y.M., Arkins, S., McCusker, R.H. Jr., Donovan, S.M., Liu, Q., Jayaraman, S., Dantzer, R. and Kelley, K.W., Macrophages synthesize and secrete a 25-kilodalton protein that binds insulin-like growth factor-I, J. Immunol., 156 (1996) 64-72.
7. Li, Y.M., Steffes, M., Donnelly, T., Liu, C., Fuh, H., Basgen, J., Bucala, R. and Vlassara, H., Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine, Proc. Natl. Acad. Sci. USA, 93 (1996) 3902-3907.
8. Li, Y.M., Tan, A.X. and Vlassara, H., Antibacterial activity of lysozyme and lactoferrin is inhibited by binding of advanced glycation-modified proteins to a conserved motif, Nat. Med., 1 (1995) 1057-1061.
9. Ma, J., Yee, A., Brewer, H.B. Jr., Das, S. 61nd Potter, H., Amyloid- associated proteins alpha 1-antichymotrypsin and apolipoprotein e promote assembly of Alzheimer beta-protein into filaments [see comments], Nature, 372 (1994) 92-94.
10. Smith, M.A., Taneda, S., Richey, P.L., Miyata, S., Yan, S.D., Stern, D., Sayre, L.M., Monnier, V.M. and Perry, G., Advanced maillard reaction end products are associated with Alzheimer disease pathology, Proc. Natl. Acad. Sci. USA, 91 (1994) 5710-5714.
11. Strittmatter, W.J. and Roses, A.D., Apolipoprotein e and Alzheimer disease, Proc. Natl. Acad. Sci. USA, 92 (1995) 4725-4727.
12. Strittmatter, W.J., Saunders, A.M., Goedert, M., Weisgraber, K.H., Dong, L.M., Jakes, R., Huang, D.Y., Pericak-Vance, M., Schmechel, D. and Roses, A.D., Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease, Proc. Natl. Acad. Sci. USA, 91 (1994) 11183-11186.
13. Strittmatter, W.J., Saunders, A.M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G.S. and Roses, A.D., Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90 (1993) 1977-1981.
14. Strittmatter, W.J., Weisgraber, K.H., Huang, D.Y., Dong, L.M., Salvesen, G.S., Pericak-Vance, M., Schmechel, D., Saunders, A.M., Goldgaber, D. and Roses, A.D., Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90 (1993) 8098-8102.
15. Thome, J., Munch, G., Muller, R., Schinzel, R., Kornhuber, J., Blum-Degen, D., Sitzmann, L., Rosler, M., Heidland, A. and Riederer, P., Advanced glycation endproducts-associated parameters in the peripheral blood of patients with Alzheimer's disease, Life. Sci., 59 (1996) 679-685.
16. Vitek, M.P., Bhattacharya, K., Glendening, J.M., Stopa, E., Vlassara, H., Bucala, R., Manogue, K. and Cerami, A., Advanced glycation end products contribute to amyloidosis in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 91 (1994) 4766-4770.
17. Vlassara, H., Recent progress on the biologic and clinical significance of advanced glycosylation end products, J. Lab. Clin. Med., 124 (1994) 19-30.