Dextromethorphan ameliorates effects of neonatal hypoxia on brain morphology and seizure threshold in rats

Developmental Brain Research

Volumn 100, Issue 1, 1997, Pages 29-34

  Laroia, Nirupama ^a   McBride, Laura ^c   Baggs, Raymond ^b   Guillet, Ronnie ^a  

^a Golisano Childrens Hospital at Strong   (United States)

^b Departments of Pathology and Laboratory Medicine and of Environmental and Occupational Medicine   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Brain; Development; Dextromethorphan; Glutamate; Hypoxia; NMDA; Passive avoidance; Seizure

Indexed keywords

DEXTROMETHORPHAN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PENTETRAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN INJURY; BRAIN SIZE; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; LONG TERM MEMORY; MALE; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; SEIZURE SUSCEPTIBILITY; SEIZURE THRESHOLD;

AGING; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; AVOIDANCE LEARNING; BRAIN; CEREBRAL CORTEX; DEXTROMETHORPHAN; HIPPOCAMPUS; HUMANS; HYPOXIA, BRAIN; MALE; PENTYLENETETRAZOLE; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; REFERENCE VALUES; SEIZURES;

ANIMALIA;

EID: 0030908240     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(97)00018-7     Document Type: Article

References (27)

1. Bitran, D., Primus, R.J. and Kellogg, C.K., Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex, Eur. J. Pharmacol, 196 (1991) 223-231.
2. Chiba, S., Long-term effect of postnatal hypoxia on the seizure susceptibility in rats, Life Sci., 37 (1985) 1597-1604.
3. Fisher, S. and Guillet, R., Neonatal caffeine alters passive avoidance retention in rats in an age- and gender-related manner, Dev. Brain Res., in press.
4. Guillet, R., Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner, Dev. Brain Res., 89 (1995) 124-128.
5. Guillet, R. and Dunham, L., Neonatal caffeine exposure and seizure susceptiblitiy in adult rats, Epilepsia, 36 (1995) 743-749.
6. Hattori, H., Morin, A.M., Schwartz, P.H., Fujikawa, D.G. and Wasterlain, C.G., Posthypoxic treatment with MK-801 reduces hypoxic-ischemic damage in the neonatal rat, Neurology, 39 (1989) 713-718.
7. Hicks, S.P., Cavanaugh, M.C. and O'Brien, E.D., Effects of anoxia on the developing cerebral cortex in the rat, Am. J. Pathol. 40 (1962) 615-635.
8. Jensen, F.F., Applegate, C., Burchfiel, J. and Lombroso, C.T., Differential effects of perinatal hypoxia and anoxia on long term seizure susceptibility in the rat, Life Sci., 49 (1991) 399-407.
9. Jensen, F.F., Applegate, C.D., Holtzman, D., Belin, T.R. and Burchfiel, J.L., Epileptogenic effect of hypoxia in the immature rodent brain, Ann. Neural. 29 (1991) 629-637.
10. Jensen, F.F., Holmes, G.L., Lombroso, C.T., Blume, H.K. and Firkusny, I.R., Age-dependent changes in long-term seizure susceptibility and behavior after hypoxia in rats, Epilepsia, 33 (1992) 971-980.
11. Jensen, F., Tsuji, M., Offutt, M., Firkusny, I. and Holtzman, D., Profound, reversible energy loss in the hypoxic immature rat brain, Dev. Brain Res., 73 (1993) 99-105.
12. Levine, S., Anoxic-ischemic encephalopathy in rats, Am. J. Pathol., 36 (1960) 1-17.
13. Matsumoto, M., The effects of perinatal hypoxia on pentylenetetrazol-induced seizures in developing rats, Life Sci., 46 (1990) 1787-1792.
14. McDonald, J.W. and Johnston, M.V., Physiological and pathophysi-ological roles of excitatory amino acids during central nervous system development, Brain Res. Rev., 15 (1990) 41-70.
15. McDonald, J.W., Silverstein, F.S. and Johnston, M.V., Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system, Brain Res., 459 (1988) 200-203.
16. Moshe, S.L. and Albala, B.J., Perinatal hypoxia and subsequent development of seizures, Physiol. Behav., 35 (1985) 819-823.
17. Oppenheim, R.W., Naturally occurring cell death during neural development, Trends Neurosci., 17 (1985) 487-493.
18. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, 2nd ed., Academic Press, New York, 1986.
19. Prince, D.A. and Feeser, H.R., Dextromethorphan protects against cerebral infarction in a rat model of hypoxia-ischemia, Neurosci. Lett., 85 (1988) 291-296.
20. Raju, T.N.K. Some animal models for the study of perinatal asphyxia, Biol. Neonate, 62 (1992) 202-214.
21. Rice, J.E., Vannucci, R.C. and Brierley, J.B., The influence of immaturity on hypoxic-ischemic brain damage in the rat, Ann. Neural. 9 (1981) 131-141.
22. Rogawski, M.A., therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines, Trends Physiol. Sci., 14 (1993) 325-331.
23. Rothman, S., synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death, J. Neurosci., 4 (1984) 1884-1891.
24. Steinberg, G.K., Kunis, D., DeLaPaz, R. and Poljak, A., Neuroprotection following focal cerebral ischaemia with the NMDA antagonist dextromethorphan, has a favourable dose response profile, Neurol. Res., 15 (1993) 174-180.
25. Steinberg, G.K., Saleh, J. and Kunis, D., Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia, Neurosci. Lett. 80 (1988) 193-197.
26. Towfighi, J., Yager, J.Y., Housman, C. and Vannucci, R.C., Neuropathology of remote hypoxic-ischemic damage in the immature rat, Acta Neuropathol. 81 (1991) 578-587.
27. Vannucci, R.C. and Duffy, T.E., Carbohydrate metabolism in fetal and neonatal rat brain during anoxia and recovery, Am. J. Physiol. 230 (1976) 1269-1275.