Identification and mechanism of formation of potentially genotoxic metabolites of tamoxifen: Study by LC-MS/MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 15, Issue 9-10, 1997, Pages 1335-1342

  Lim, C K ^a   Yuan, Zhi Xin ^a   Jones, R M ^a   White, I N H ^a   Smith, L L ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Electrospray ionization mass spectrometry; HPLC; Reactive and genotoxic metabolites of tamoxifen; Tamoxifen metabolism in liver microsomes

Indexed keywords

4 HYDROXYTAMOXIFEN; DRUG METABOLITE; TAMOXIFEN;

ANIMAL TISSUE; CONFERENCE PAPER; DETOXIFICATION; DRUG IDENTIFICATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME METABOLISM; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; DNA DAMAGE; ESTROGEN ANTAGONISTS; HUMANS; MASS SPECTROMETRY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; MUTAGENS; TAMOXIFEN;

EID: 0030908194     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(96)02007-9     Document Type: Conference Paper

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