Transforming growth factor-β3 mediated modulation of cell cycling and attenuation of 5-fluorouracil induced oral mucositis

European Journal of Cancer Part B: Oral Oncology

Volumn 33, Issue 1, 1997, Pages 47-54

  Sonis, S T ^a   Van Vugt, A G ^a   Brien, J P O ^a   Muska, A D ^a   Bruskin, A M ^b   Rose, A ^b   Haley, J D ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Oncogene Science Inc   (United States)

Author keywords

Chemoprotection; DNA ploidy; Epithelial cell proliferation; Oral mucositis; PCNA; Transformi8ng growth factor beta

Indexed keywords

CYCLINE; FLUOROURACIL; TRANSFORMING GROWTH FACTOR BETA3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; EPITHELIUM CELL; MUCOSA INFLAMMATION; NONHUMAN; PLOIDY; PRIORITY JOURNAL; SURVIVAL;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BIOLOGICAL MARKERS; CELL DIVISION; CRICETINAE; FLUOROURACIL; INJECTIONS, SUBCUTANEOUS; MOUTH MUCOSA; PROLIFERATING CELL NUCLEAR ANTIGEN; SEVERITY OF ILLNESS INDEX; STOMATITIS; SURVIVAL RATE; TRANSFORMING GROWTH FACTOR BETA; WEIGHT LOSS;

EID: 0030907791     PISSN: 09641955     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0964-1955(96)00043-7     Document Type: Article

References (27)

1. 1. Roberts, A. and Sporn, M. B. The transforming growth factors-β. In Handbook of Experimental Pharmacology, vol. 95/1: Peptide Growth Factors and their Receptors, eds M.B. Sporn and A. Roberts. Springer, Heidelberg. 1990, pp. 419-472.
2. 2. Barnard, J. A., Lyons, R. and Moses, H. L., The cell biology of transforming growth factor β. Biochim Biophys Acta, 1990, 1032, 79-87.
3. 3. Hampson, J., Ponting, I. L., Cook, N., et al, The effects of TGF beta on haemopoietic cells. Growth Factors, 1989, 1, 193-202.
4. 4. Strife, A., Lambek, C., Perez, A., et al, The effects of TGF-β3 on the growth of highly enriched hematopoietic progenitor cells derived from normal human bone marrow and peripheral blood. Cancer Research, 1991, 51, 4828-4836.
5. kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes and Development, 1994, 8, 9-22.
6. 6. Sherr, C. J. and Roberts, J. M., Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Development, 1995, 9, 1149-1163.
7. 7. Wrana, J. L., Attisano, L., Wieser, R., Ventura, F. and Massague, J., Mechanism of activation of the TGF-β receptor. Nature, 1994, 370, 341-347.
8. 8. Derynck, R., TGF-β-receptor-mediated signaling. Trends in Biological Sciences, 1994, 19, 548-553.
9. 9. Sonis, S. T. Oral complications of cancer chemotherapy. In: Cancer, Principles and Practice of Oncology, eds V. T. Hellman Jr and S. A. Rosenburg. Lippincott, Philadelphia, 1993, pp. 2385-2394.
10. 10. Sonis, S., Lindquist, L., Van Vugt, A., et al, Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor β3. Cancer Research, 1994, 54, 1135-1138.
11. 11. Boulton, R. A. and Hodgson, H. J., Assessing cell proliferation: A methodological review. Clinical Science, 1995, 88, 119-130.
12. 12. Stewart, A. A., Haley, J. D., Qu, G.-Y. et al., Isolation and physical characterization of native and recombinant transforming growth factor beta-3. Growth Factors, in press.
13. 13. Cerletti, N., McMaster, G. K., Schmitz, A. and Cox, D., Preparation of biologically active TGF-β2 by in vitro folding of the monomeric protein expressed in E. coli. Protein Science, 1993, 2 (Suppl. 1), 62.
14. 14. Iwata, K. K., Fryling, C. M., Knott, W. B. and Todaro, G. J., Isolation of tumor cell growth inhibiting factors from human rhabdomyosarcoma cell line. Cancer Research, 1985, 45, 2689-2694.
15. 15. Gibbs, S. J. and Casarett, G. W., Spatial distribution of cells in mitotic and DNA-synthesis phases of the cell cycle in hamster cheek pouch epithelium. Journal of Dental Research, 1972, 54, 30-38.
16. 16. Sonis, S. T., Tracey, C., Shklar, G., Jensen, J. and Florine, D., An animal model for mucositis induced by cancer chemotherapy. Oral Surgery, Oral Medicine, Oral Pathology, 1990, 69, 437-443.
17. 17. England, M. C. and Burke, G., Diurnal variation in DNA synthesis in hamster oral epithelium. Journal of Dental Research, 1971, 50, 976.
18. 18. Kellet, M., Potten, C. S. and Rew, D. A., A comparison of in vivo cell proliferation measurements in the intestine of mouse and man. Epithelial Cell Biology, 1992, 1, 147-155.
19. 19. Pallidino, M. A., Morris, R. E., Starnes, H. F. and Levinson, A. D., The transforming growth factor-betas: A new family of immunoregulatory molecules. New York Academy of Science, 1990, 593, 18-187.
20. 20. Lemoli, R. M., Strife, A., Clarkson, B. D., Haley, J. D. and Gulati, S., TGF-β3 protects normal human hematopoietic progenitor cells treated with 4 hydroperoxycyclophosphamide in vitro. Experimental Hematology, 1992, 20, 1252-1256.
21. 21. Pierce, D. F. and Coffey, R. J., Therapeutic manipulation of cytokines: Transforming growth factor beta-1 protects mice treated with lethal doses of cytarabine. American Surgeon, 1994, 60, 18-25.
22. 22. Grzegorzewski, Ruscetti, F., Usui, N., et al, Recombinant transforming growth factor β1 and β2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin. Journal of Experimental Medicine, 1994, 180, 1047-1057.
23. 23. Cox, D. A., Transforming growth factor-beta 3. Cell Biology International, 1995, 19, 357-371.
24. 24. Beck, L. S., DeGuzman, L., Lee, W. P., Xu, Y., Siegal, M. W. Amento, E. P., One systemic administration of transforming growth factor-β1 reverses age-or glucocorticoid-impaired wound healing. Journal of Clinical Investigation, 1993, 92, 2841-2849.
25. 25. Markowitz, S., Wang, J., Myeroff, L., et al, Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science, 1995, 268, 1336-1338.
26. 26. Hunter, T. and Pines, J., Cyclins and cancer II: Cyclin D and cdk inhibitors come of age. Cell, 1994, 79, 573-582.
27. 27. Zugmaier, G., Palk, S., Wilding, G., et al, Transforming growth factor β1 induces cachexia and systemic fibrosis without an antitumor effect in nude mice. Cancer Research, 1991, 51, 3590-3594.