Psychiatric disorders in the relatives of depressed probands. II. Familial loading for comorbid non-depressive disorders based upon proband age of onset

Journal of Affective Disorders

Volumn 42, Issue 1, 1997, Pages 23-28

  Rende, Richard ^a   Weissman, Myrna ^b   Rutter, Michael ^c   Wickramaratne, Priya ^b   Harrington, Richard ^d   Pickles, Andrew ^c  

^a RUTGERS UNIVERSITY   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALCOHOLISM; ANTISOCIAL BEHAVIOR; ANXIETY; ARTICLE; COMORBIDITY; DEPRESSION; FAMILY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PERSONALITY DISORDER; PRIORITY JOURNAL; RELATIVE;

EID: 0030907363     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0327(97)84643-5     Document Type: Article

References (17)

1. Cox, D.R. (1972) Regression models and life tables. J. R. Statist. Soc. B, 34, 187-220.
2. Harrington, R., Rutter, M., Weissman, M., Fudge, H., Groothues, C., Bredenkamp, D., Pickles, A., Rende, R. and Wickramaratne, P. (1997) Psychiatric diagnoses in the relatives of depressed probands. I. Comparison of prepubertal, adolescent and early adult onset cases. J. Affect. Disord. 42, 9-22.
3. Kendler, K., Heath, A., Neale, M., Kessler, R. and Eaves, L. (1993) Alcoholism and major depression in women: A twin study of the causes of comorbidity. Arch. Gen. Psychiatry 50, 690-698.
4. Kendler, K., Neale, M., Kessler, R., Heath, A. and Eaves, L. (1992) Major depression and generalized anxiety disorders: Same genes, (partly) different environments? Arch. Gen. Psychiatry 49, 716-722.
5. Kupfer, D.J., Frank, E., Carpenter, L.L. and Neiswanger, K. (1989) Family history in recurrent depression. J. Affect. Disord. 17, 113-119.
6. Moldin, S.O., Reich, T. and Rice, J.P. (1991) Current perspectives on the genetics of unipolar depression. Behav. Genet., 21, 211-242.
7. Merikangas, K.R., Risch, N.J. and Weissman, M.M. (1994) Comorbidity and co-transmission of alcoholism, anxiety and depression. Psychol. Med., 24, 69-80.
8. Regier, D.A., Farmer, M., Rae, D., Locke, B., Keith, S., Judd, L. and Goodwin, F. (1990) Comorbidity of mental disorders with alcohol and drug abuse. J. Am. Med. Assoc., 240, 2511-2518.
9. Rende, R. and Plomin, R. (1994) Genetic influences on behavioural development. In M. Rutter and D. Hay (Eds.), Development through life: A handbook for clinicians. Blackwell, Oxford, pp. 26-48.
10. Rende, R. and Plomin, R. (1995) Nature, nurture, and the development of psychopathology. In D. Cicchetti and D. Cohen (Eds.), Handbook of Developmental Psychopathology, Vol. 1: Theory and Methods. Wiley, New York, NY, pp. 291-314.
11. Rhode, P., Lewinsohn, P.M. and Seeley, J.R. (1993) Comorbidity of unipolar depression: II. Comorbidity with other mental disorders in adolescents and adults. J. Abnorm. Psychol. 100, 214-222.
12. Rutter, M., Bolton, P., Harrington, R., Le Couteur, A., Macdonald, H. and Simonoff, E. (1990) Genetic factors in child psychiatric disorders-I. A review of research strategies. J. Child Psychol. Psychiatry 31, 3-37.
13. Strober, M. (1992) Relevance of early age of onset in genetic studies of bipolar affective disorder. J. Am. Acad. Child Adolesc. Psychiatry 31, 605-610.
14. Todd, R.D., Neuman, R., Geller, B., Fox, L.W. and Hickok, J. (1993) Genetic studies of affective disorders: Should we be starting with childhood onset probands? J. Am. Acad. Child Adolesc. Psychiatry 32, 1164-1171.
15. Weissman, M.M., Gershon, E.S., Kidd, K.K., Prusoff, B.A., Leckman, J.F., Dibble, E., Hamovit, J., Thompson, W.D., Pauls, D.L. and Guroff, J.J. (1984a) Psychiatric disorders in the relatives of probands with affective disorders. Arch. Gen. Psychiatry 41, 13-21.
16. Weissman, M.M., Wickramaratne, P., Merikangas, K.R., Leckman, J.F., Prusoff, B.A., Caruso, K.A., Kidd, K.K. and Gammon, G.D. (1984b) Onset of major depression in early adulthood. Arch. Gen. Psychiatry 41, 1136-1143.
17. Weissman, M.M., Warner, V., Wickramaratne, P. and Prusoff, B.A. (1988) Early-onset major depression in parents and their children. J. Affect. Disord. 15, 269-277.