Myoglobinuric acute renal failure in the rat: A role for acidosis?

Experimental Nephrology

Volumn 5, Issue 3, 1997, Pages 210-216

  Heyman, S N ^a,c   Greenbaum, R ^a   Shina, A ^a   Rosen, S ^b   Brezis, M ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Acid base balance; Alkalosis; Hematin; Isolated perfused kidney; Myoglobin; Rat kidney; Renal failure, acute acidosis

Indexed keywords

HEMATIN;

ACID BASE BALANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; KIDNEY FAILURE; KIDNEY TUBULE ACIDOSIS; MALE; MYOGLOBINURIA; NONHUMAN; PRIORITY JOURNAL; RAT;

ACID-BASE EQUILIBRIUM; ACIDOSIS; ANIMALS; DISEASE MODELS, ANIMAL; HYDROGEN-ION CONCENTRATION; KIDNEY FAILURE, ACUTE; KIDNEY TUBULES; MALE; MYOGLOBINURIA; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030907131     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Zager RA, Foerder CA: Effects of inorganic iron and myoglobin on in vitro proximal tubular lipid peroxidation and cytotoxicity. J Clin Invest 1992;89:989-995.
2. Zager RA, Burkhart KM, Conrad DS, Gmur DJ: Iron, heme oxygenase and glutathione: Effects on myohemoglubinuric proximal tubular injury. Kidney Int 1995;48:1624-1634.
3. Heyman SN, Rosen S, Fuchs S, Epstein FH, Brezis M: Myoglobinuric acute renal failure in the rat: A role for medullary hypoperfusion, hypoxia and tubular obstruction. J Am Soc Nephrol 1996;7:1066-1072.
4. Baker SL, Dodds EC: Obstruction of renal tubules during the excretion of hemoglobin. Br J Exp Pathol 1925;6:247-260.
5. Perri GC, Gerini P: Uraemia in the rabbit after injection of crystalline myoglobin. Br J Exp Pathol 1952;33:440-444.
6. Muckart DJJ, Moodley M, Naidu AG, Reddy ADR, Meineke KR: Prediction of acute renal failure following soft-tissue injury using the venous bicarbonate concentration. J Trauma 1992;33:813-817.
7. Bywaters GL, Stead JK: The production of renal failure following injection of solutions containing myohemoglobin. Q J Exp Physiol 1944;33:53-70.
8. Bywaters EGL: Ischemic muscle necrosis. JAMA 1944;124:1103-1109.
9. Eneas JF, Schoenfeld PY, Humphreys MH: The effect of infusion of mannitol-sodium bicarbonate on the clinical course of myoglobinuria. Arch Intern Med 1979;139:801-805.
10. Ron D, Taitelman U, Michaelson M, Bar-Joseph G, Bursztein S, Better O: Prevention of acute renal failure in traumatic rhabdomyolysis. Arch Intern Med 1984;144:277-280.
11. Better OS, Stein JH: Current concepts: Early management of shock and prophylaxis of acute renal failure in traumatic rhabdomyolysis. N Engl J Med 1990;322:825-829.
12. Bank N, Better OS: Acid-base balance and acute renal failure. Miner Electrolyte Metab 1991;17:116-123.
13. Zager RA: Studies of the mechanisms and protective maneuvers in myoglobinuric acute renal injury. Lab Invest 1989;60:619-629.
14. Kent KS, Pesce AJ, Clyne DH, Pollak VE: Coprecipitation of Tamm-Horsfall protein with myoglobin, hemoglobin, Bence-Jones protein and albumin. Clin Res 1977;25:594.
15. Sanders PW, Booker BB, Bishop JB, Cheung HC: Mechanisms of intranephronal proteinaceous cast formation by low molecular weight proteins. J Clin Invest 1990;85:570-576.
16. Wu AHB, Laios I, Green S, et al: Immunoassays for serum and urine myoglobin: Myoglobin clearance assessed as a risk factor for acute renal failure. Clin Chem 1994;40:796-802.
17. Zager RA: Myoglobin depletes renal adenine nucleotide pools in the presence and absence of shock. Kidney Int 1991;39:111-119.
18. Litwin MS, Walter CW, Jackson N: Experimental production of acute renal tubular necrosis. I. The role of gram-negative bacteremia. II. The toxicity of acid hematin. III. Acid hematin-the etiologic pigment. Ann Surg 1960;152; 1010-1025.
19. Shah SV, Walker PD: Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol 1988;255: F438-F443.
20. Paller MS: Hemoglobin- and myoglobin-induced acute renal failure in rats: Role of iron in nephrotoxicity. Am J Physiol 1988;255:F539-F544.
21. Zager RA: Combined mannitol and deferoxamine therapy for myohemoglobinuric renal injury and oxidant tubular stress. Mechanistic and therapeutic implications. J Clin Invest 1992;90:711-719.
22. Miller JH, McDonald RK: The effect of hemoglobin on renal function in the human. J Clin Invest 1951;30:1033-1040.
23. Liberthal W, Wolf EF, Merrill EW, Levinski NG, Valeri CR: Hemodynamic effects of different preparations of stroma free hemolysates in the isolated perfused rat kidney. Life Sci 1987;41:2525-2533.
24. Wellum GR, Irvine TW Jr, Zervas NT: Cerebral vasoactivity of heme proteins in vitro. Some mechanistic considerations. J Neurosurg 1982;56:777-783.
25. Edwards DH, Byrne JV, Griffith TM: The effect of chronic subarachnoid hemorrhage on basal endothelium-derived relaxing factor activity in intrathecal cerebral arteries. J Neurosurg 1992;76:830-837.
26. Ross BD, Epstein FH, Leaf A: Sodium reabsorption in the perfused rat kidney. Am J Physiol 1973;225:1165-1171.
27. Epstein FH, Brosnan JT, Tange JD, Ross BD: Improved function with amino acids in the isolated perfused kidney. Am J Physiol 1982;243: F284-F292.
28. Heyman SN, Brezis M, Epstein FH, Spokes K, Silva P, Rosen S: Early renal medullary hypoxic injury from radiocontrast and indomethacin. Kidney Int 1991;40:632-642.
29. Good DW, Burg MB: Ammonia production by individual segments of the rat nephron. J Clin Invest 1984;73:602-610.
30. Brezis M, Rosen S, Silva P, Epstein FH: Transport activity modifies thick ascending limb damage in the isolated perfused kidney. Kidney Int 1984;25:65-72.
31. Brezis M, Rosen S: Mechanisms of disease. Hypoxia of the renal medulla: Its implication for disease. N Engl J Med 1995;332:647-655.
32. 2+ homeostasis in the pH paradox of reperfusion injury to neonatal rat cardiac myocytes. Am J Physiol 1993;265: C129-C137.
33. Koop A, Piper HM: Protection of energy status of hypoxic cardiomyocytes by mild acidosis. J Mol Cell Cardiol 1992;24:55-65.
34. Simon RP, Niro M, Gwinn R: Brain acidosis induced by hypercarbic ventilation attenuates focal ischemic injury. J Pharmacol Exp Ther 1993;267:1428-1431.
35. Andreeva N, Khodorov B, Stelmashook E, Sokolova S, Cragoe R Jr, Victorov I: 5-(N-Ethyl-N-isopropyl) amiloride and mild acidosis protect cultured cerebellar granule cells against glutamate-induced delayed neuronal death. Neuroscience 1992;49:175-181.
36. Gores GJ, Nieminen AL, Fleishman KE, Dawson TL, Herman B, Lemasters JJ: Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes. Am J Physiol 1988;255: C315-C322.
37. Nieminen AL, Dawson TL, Gores GJ, Kawanishi T, Herman B, Lemasters JJ: Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals. Biochem Biophys Res Commun 1990;167:600-606.
38. Weinberg JM, Davis JA, Roeser NF, Venkatachalam MA: Role of increased cytosolic free calcium in the pathogenesis of rabbit proximal tubule cell injury and protection by glycine or acidosis. J Clin Invest 1991;87:581-590.
39. Almeida AR, Wetzels JF, Bunnachak D, Burke TJ, Chaimovitz C, Hammond WS, Schrier RW: Acute phosphate depletion and in vitro rat proximal tubule injury: Protection by glycine and acidosis. Kidney Int 1992;41:1494-1500.
40. Rodeheaver DP, Schnellmann RG: Extracellular acidosis ameliorates metabolic-inhibitor-induced and potentiates oxidant-induced cell death in renal proximal tubules. J Pharmacol Exp Ther 1993;265:1355-1360.
41. Zager RA, Schimpf BA, Gmur DJ: Physiological pH. Effect on posthypoxic proximal tubular injury. Circ Res 1993;72:837-846.
42. Shanley PF, Shapiro JI, Chan L, Burke TJ, Johnson GC: Acidosis and hypoxic medullary injury in the isolated perfused kidney. Kidney Int 1988;34:791-796.
43. West JB: Respiratory physiology. Ventilation, blood flow and gas exchange; in Nadel JA, Murray JF (eds): Textbook of Respiratory Medicine. Philadelphia, Saunders, 1988, pp 47-84.
44. i). J Am Soc Nephrol 1995;6:822.
45. + and alpha 2 receptors in escape from sympathetic vasoconstriction. Am J Physiol 1991;261:H868-H873.
46. Tateishi J, Faber JE: Inhibition of arteriole alpha 2- but not alpha 1-adrenoceptor constriction by acidosis and hypoxia in vitro. Am J Physiol 1995;268:H2068-H2076.
47. Rose CE Jr, Walker BR, Erickson A, Kaiser DL, Carey RM, Anderson RJ: Renal and cardiovascular responses to acute hypercapnic acidosis in conscious dogs: Role of renin-angiotensin. J Cardiovasc Pharmacol 1982;4:676-687.
48. Walley KR, Lewis TH, Wood LD: Acute respiratory acidosis decreases left ventricular contractility but increases cardiac output in dogs. Circ Res 1990;67:628-635.
49. Brimioulle S, Lejueune P, Vachiery JL, Leeman M, Melot C, Naeije R: Effects of acidosis and alkalosis on hypoxic pulmonary vasoconstriction in dogs. Am J Physiol 1990;258: H347-H353.
50. Anderson RJ, Pluss WT, Bell J, Zerbe GG: Effect of hypoxia and hypercapnic acidosis on renal autoregulation in the dog: Role of renal nerves. Clin Sci 1983;65:533-538.
51. Robillard JE, Kisker CT: Effect of metabolic acidosis on fetal renal hemodynamics. J Dev Physiol 1987;9:105-112.
52. Brezis M, Heyman SN, Epstein F: Determinants of intrarenal oxygenation. 2. Hemodynamic effects. Am J Physiol 1994;267:F1063-F1068.
53. Zager RA, Gamelin LM: Pathogenetic mechanisms in experimental hemoglobinuric acute renal failure. Am J Physiol 1989;256:F446-F455.