메뉴 건너뛰기




Volumn 390, Issue 1-2, 1997, Pages 113-120

Modulation of mitomycin C mutagenicity on Saccharomyces cerevisiae by glutathione, cytochrome P-450, and mitochondria interactions

Author keywords

Antiblastic drug; Gene conversion; Point mutation; Respiratory deficient mutant; Short term mutagenesis assay; Yeast

Indexed keywords

CYTOCHROME P450; GLUTATHIONE; MITOMYCIN C;

EID: 0030906840     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1218(97)00007-4     Document Type: Article
Times cited : (13)

References (54)
  • 1
    • 78651117965 scopus 로고
    • Molecular mechanism of mitomycin action: linking of complementary DNA strands
    • Iyer, V.N. and W. Szybalski (1963) Molecular mechanism of mitomycin action: linking of complementary DNA strands, Proc. Natl. Acad. Sci. USA, 50, 355-362.
    • (1963) Proc. Natl. Acad. Sci. USA , vol.50 , pp. 355-362
    • Iyer, V.N.1    W. Szybalski2
  • 2
    • 0001896852 scopus 로고
    • Potential bioreductive alkylating agents
    • in: A.C. Sartorelli (Ed.) American Chemical Society, Washington, DC
    • Lin, A.J., L.A. Cosby and A.C. Sartorelli (1976) Potential bioreductive alkylating agents, in: A.C. Sartorelli (Ed.), Cancer Chemotherapy, American Chemical Society, Washington, DC, pp. 71-86.
    • (1976) Cancer Chemotherapy , pp. 71-86
    • Lin, A.J.1    L.A. Cosby2    A.C. Sartorelli3
  • 3
    • 0022511678 scopus 로고
    • DNA alkylation by enzyme-activated mitomycin C
    • Pan, S.S., T. Iracki and N.R. Bachur (1986) DNA alkylation by enzyme-activated mitomycin C, Mol. Pharmacol., 29, 622-628.
    • (1986) Mol. Pharmacol. , vol.29 , pp. 622-628
    • Pan, S.S.1    T. Iracki2    N.R. Bachur3
  • 4
    • 0023136662 scopus 로고
    • Modeling of the electrophilic activation of mitomycins: chemical evidence for the intermediacy of a mitosene semiquinone as the active electrophile
    • Egbertson, M. and S.J. Danishefsky (1987) Modeling of the electrophilic activation of mitomycins: chemical evidence for the intermediacy of a mitosene semiquinone as the active electrophile, J. Am. Chem. Soc., 109, 2204-2205.
    • (1987) J. Am. Chem. Soc. , vol.109 , pp. 2204-2205
    • Egbertson, M.1    S.J. Danishefsky2
  • 5
    • 0022622807 scopus 로고
    • Generation of reactive oxygen radicals through bioactivation of mitomycin C antibiotic
    • Pritsos, C.A. and A.C. Sartorelli (1986) Generation of reactive oxygen radicals through bioactivation of mitomycin C antibiotic, Cancer Res., 46, 3528-3532.
    • (1986) Cancer Res. , vol.46 , pp. 3528-3532
    • Pritsos, C.A.1    A.C. Sartorelli2
  • 6
    • 0001333113 scopus 로고
    • Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct
    • Tomasz, M., D. Chowdary, R. Lipman, S. Shimotakahara, D. Veiro, V. Walker and G.L. Verdine (1986) Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct, Proc. Natl. Acad. Sci. USA, 83, 6702-6706.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 6702-6706
    • Tomasz, M.1    D. Chowdary R. Lipman S. Shimotakahara D. Veiro V. Walker2    G.L. Verdine3
  • 7
    • 0023123806 scopus 로고
    • Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
    • Tomasz, M., R. Lipman, D. Chowdary, J. Pawlak, G.L. Verdine and K. Nakanishi (1987) Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA, Science, 235, 1204-1208.
    • (1987) Science , vol.235 , pp. 1204-1208
    • Tomasz, M.1    R. Lipman D. Chowdary J. Pawlak G.L. Verdine2    K. Nakanishi3
  • 8
    • 0017265763 scopus 로고
    • Studies related to antitumor antibiotics. V. Reaction of mitomycin C with DNA examined by ethidium fluorescence assay
    • Lown, J.W., A. Begleiter, D. Johnson and A.R. Morgan (1976) Studies related to antitumor antibiotics. V. Reaction of mitomycin C with DNA examined by ethidium fluorescence assay, Can. J. Biochem., 54, 110-119.
    • (1976) Can. J. Biochem. , vol.54 , pp. 110-119
    • Lown, J.W.1    A. Begleiter D. Johnson2    A.R. Morgan3
  • 9
    • 0021345793 scopus 로고
    • Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH cytochrome P-450 reductase and xanthine oxidase
    • Pan, S.S., P.A. Andrews, C.J. Glover and N.R. Bachur (1984) Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH cytochrome P-450 reductase and xanthine oxidase, J. Biol. Chem., 259, 959-966.
    • (1984) J. Biol. Chem. , vol.259 , pp. 959-966
    • Pan, S.S.1    P.A. Andrews C.J. Glover2    N.R. Bachur3
  • 10
    • 0025166614 scopus 로고
    • DNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues
    • Dusre, L., S. Rajagopalan, H.M. Eliot, J.M. Covey and B.K. Sinha (1990) DNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues, Cancer Res., 50, 648-652.
    • (1990) Cancer Res. , vol.50 , pp. 648-652
    • Dusre, L.1    S. Rajagopalan H.M. Eliot J.M. Covey2    B.K. Sinha3
  • 12
    • 0027051111 scopus 로고
    • Role of NAD(P)H: (quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia
    • Begleiter, A., E. Robotham and M.K. Leith (1992) Role of NAD(P)H: (quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia, Mol. Pharmacol., 41, 677.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 677
    • Begleiter, A.1    E. Robotham2    M.K. Leith3
  • 13
    • 0023280679 scopus 로고
    • Mitomycin C resistant L1210 leukemia cells: association with pleiotropic drug resistance
    • Dorr, R.T., J.D. Liddil, J.M. Trent and W.S. Dalton (1987) Mitomycin C resistant L1210 leukemia cells: association with pleiotropic drug resistance, Biochem. Pharmacol., 36, 3115-3120.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 3115-3120
    • Dorr, R.T.1    J.D. Liddil2    J.M. Trent3    W.S. Dalton4
  • 14
    • 0343777938 scopus 로고
    • Effect of glutathione (GSH) depletion by diethylmalate (DEM) or buthionine-S,R-sulfoximine (BSO) on mitomycin C (MC) toxicity towards EMT6 mouse mammary tumor cells
    • McGurl, J. and K.A. Kennedy (1989) Effect of glutathione (GSH) depletion by diethylmalate (DEM) or buthionine-S,R-sulfoximine (BSO) on mitomycin C (MC) toxicity towards EMT6 mouse mammary tumor cells, Proc. Am. Assoc. Cancer Res., 30, 543.
    • (1989) Proc. Am. Assoc. Cancer Res. , vol.30 , pp. 543
    • McGurl, J.1    K.A. Kennedy2
  • 15
    • 0026779820 scopus 로고
    • Potentiation of mitomycin C cytotoxicity by glutathione depletion in a multi-drug resistant mouse leukemia cell line
    • Xu, B.H. and S.V. Singh (1992) Potentiation of mitomycin C cytotoxicity by glutathione depletion in a multi-drug resistant mouse leukemia cell line, Cancer Lett., 66, 49-53.
    • (1992) Cancer Lett. , vol.66 , pp. 49-53
    • Xu, B.H.1    S.V. Singh2
  • 16
    • 0027442709 scopus 로고
    • Biochemical characterization of a mitomycin C resistant colon cancer cell line variant
    • Perry, R.R., Y. Kang and B. Greaves (1993) Biochemical characterization of a mitomycin C resistant colon cancer cell line variant, Biochem. Pharmacol., 46, 1999-2005.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 1999-2005
    • Perry, R.R.1    Y. Kang2    B. Greaves3
  • 17
    • 0028223827 scopus 로고
    • Mitomycin C sensitivity in human bladder cancer cell: possible role of glutathione and glutathione transferase in resistance
    • Xu, B.H., V. Gupta and S.V. Singh (1994) Mitomycin C sensitivity in human bladder cancer cell: possible role of glutathione and glutathione transferase in resistance, Arch. Biochem. Biophys., 308, 164-170.
    • (1994) Arch. Biochem. Biophys. , vol.308 , pp. 164-170
    • Xu, B.H.1    V. Gupta2    S.V. Singh3
  • 18
    • 0026727829 scopus 로고
    • Effect of treatment duration and glutathione depletion on mitomycin C
    • Perry, R.R., B.R. Greaves, U. Rasberry and S.C. Barranco (1995) Effect of treatment duration and glutathione depletion on mitomycin C, Cancer Res., 52, 4608-4612.
    • (1995) Cancer Res. , vol.52 , pp. 4608-4612
    • Perry, R.R.1    B.R. Greaves U. Rasberry2    S.C. Barranco3
  • 19
    • 0019835111 scopus 로고
    • Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes
    • Tomasz, M. and R. Lipman (1981) Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes, Biochemistry, 20, 556-561.
    • (1981) Biochemistry , vol.20 , pp. 556-561
    • Tomasz, M.1    R. Lipman2
  • 20
  • 21
    • 0025352024 scopus 로고
    • Decreased NADPH: cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions
    • Hoban, P.R., M.I. Walton, C.N. Robson, J. Godden, I.J. Stratford, P. Workman, A.L. Harris and I.D. Hickson (1990) Decreased NADPH: cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions, Cancer Res., 50, 4692-4697.
    • (1990) Cancer Res. , vol.50 , pp. 4692-4697
    • Hoban, P.R.1    M.I. Walton C.N. Robson J. Godden I.J. Stratford P. Workman A.L. Harris2    I.D. Hickson3
  • 22
    • 0027746244 scopus 로고
    • Characterization of a set of Chinese hamster ovary variant cell lines demonstrating differing sensitivity to mitomycin C
    • Kuehl, B.L., M. Buchwald and A.M. Rauth (1993) Characterization of a set of Chinese hamster ovary variant cell lines demonstrating differing sensitivity to mitomycin C, Oncol. Res., 5, 213-221.
    • (1993) Oncol. Res. , vol.5 , pp. 213-221
    • Kuehl, B.L.1    M. Buchwald2    A.M. Rauth3
  • 23
    • 0024557260 scopus 로고
    • Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions
    • Marshall, R.S., M.C. Patterson and A.M. Rauth (1989) Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions, Br. J. Cancer, 59, 341-346.
    • (1989) Br. J. Cancer , vol.59 , pp. 341-346
    • Marshall, R.S.1    M.C. Patterson2    A.M. Rauth3
  • 24
    • 0025797202 scopus 로고
    • Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase
    • Dulhanty, A.M. and G.F. Whitmore (1991) Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase, Cancer Res., 51, 1860-1865.
    • (1991) Cancer Res. , vol.51 , pp. 1860-1865
    • Dulhanty, A.M.1    G.F. Whitmore2
  • 25
    • 0343342296 scopus 로고
    • Effects of hypoxia upon detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells
    • O'Dwyer, P.J., K.S. Yao, A.K. Godwin and M. Clayon (1993) Effects of hypoxia upon detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells, Proc. Am. Assoc. Cancer Res., 34, 12.
    • (1993) Proc. Am. Assoc. Cancer Res. , vol.34 , pp. 12
    • O'Dwyer, P.J.1    K.S. Yao A.K. Godwin2    M. Clayon3
  • 26
    • 0027163881 scopus 로고
    • Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY25282 and BMY25067, in isolated rat hepatocytes
    • Silva, J.M., S. Khan and P.J. O'Brien (1993) Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY25282 and BMY25067, in isolated rat hepatocytes, Biochem. Pharmacol., 45, 2303-2309.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 2303-2309
    • Silva, J.M.1    S. Khan2    P.J. O'Brien3
  • 27
    • 0018852436 scopus 로고
    • Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells
    • Kennedy, K.A., S. Rockwell and A.C. Sartorelli (1980) Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells, Cancer Res., 40, 2356-2360.
    • (1980) Cancer Res. , vol.40 , pp. 2356-2360
    • Kennedy, K.A.1    S. Rockwell2    A.C. Sartorelli3
  • 28
    • 0021057557 scopus 로고
    • Effects of mitomycin C alone and in combination with X-rays on EMT6 mouse mammary tumors in vivo
    • Rockwell, S. (1983) Effects of mitomycin C alone and in combination with X-rays on EMT6 mouse mammary tumors in vivo, J. Natl. Cancer Inst., 71, 765-771.
    • (1983) J. Natl. Cancer Inst. , vol.71 , pp. 765-771
    • Rockwell, S.1
  • 29
    • 0016771744 scopus 로고
    • A yeast for simultaneous detection of induced mitotic crossing-over, mitotic gene conversion and reverse mutation
    • Zimmermann, F.K., R. Kern and H. Rasenberg (1975) A yeast for simultaneous detection of induced mitotic crossing-over, mitotic gene conversion and reverse mutation, Mutation Res., 28, 381-388.
    • (1975) Mutation Res. , vol.28 , pp. 381-388
    • Zimmermann, F.K.1    R. Kern2    H. Rasenberg3
  • 30
    • 0023863353 scopus 로고
    • Mitotic crossing-over by anticancer drugs in Saccharomyces cerevisiae strain D5
    • Ferguson, L.R. and P.M. Turner (1988) Mitotic crossing-over by anticancer drugs in Saccharomyces cerevisiae strain D5, Mutation Res., 204, 239-249.
    • (1988) Mutation Res. , vol.204 , pp. 239-249
    • Ferguson, L.R.1    P.M. Turner2
  • 31
    • 0023946498 scopus 로고
    • `Petite' mutagenesis by anticancer drugs in Saccharomyces cerevisiae
    • Ferguson, L.R. and P.M. Turner (1988) `Petite' mutagenesis by anticancer drugs in Saccharomyces cerevisiae, Eur. J. Cancer Clin. Oncol., 24, 591-596.
    • (1988) Eur. J. Cancer Clin. Oncol. , vol.24 , pp. 591-596
    • Ferguson, L.R.1    P.M. Turner2
  • 32
    • 0026799775 scopus 로고
    • Induction of the cytoplasmic `petite' mutation by chemical and physical agents in Saccharomyces cerevisiae
    • Ferguson, L.R. and R.C. von Borstel (1992) Induction of the cytoplasmic `petite' mutation by chemical and physical agents in Saccharomyces cerevisiae, Mutation Res., 265, 103-148.
    • (1992) Mutation Res. , vol.265 , pp. 103-148
    • Ferguson, L.R.1    R.C. von Borstel2
  • 33
    • 0015526919 scopus 로고
    • Biogenesis of mitochondria. XXI. Studies on the nature of the mitochondrial genome in yeast: the degenerative effects of ethidium bromide on mitochondrial genetic information in a respiratory competent strain
    • Nagley, P. and A.W. Linnane (1972) Biogenesis of mitochondria. XXI. Studies on the nature of the mitochondrial genome in yeast: the degenerative effects of ethidium bromide on mitochondrial genetic information in a respiratory competent strain, Mol. Biol., 66, 181-193.
    • (1972) Mol. Biol. , vol.66 , pp. 181-193
    • Nagley, P.1    A.W. Linnane2
  • 34
    • 0024975592 scopus 로고
    • Reaction of o-phthalaldehyde with aminoacids and glutathione. Application to high-performance liquid chromatography determination
    • Morineau, G., M. Azoulay and F. Frappier (1989) Reaction of o-phthalaldehyde with aminoacids and glutathione. Application to high-performance liquid chromatography determination, J. Chromatogr., 467, 209-216.
    • (1989) J. Chromatogr. , vol.467 , pp. 209-216
    • Morineau, G.1    M. Azoulay2    F. Frappier3
  • 35
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsome. I. Evidence for its hemoprotein nature
    • Omura, T. and R. Sato (1964) The carbon monoxide-binding pigment of liver microsome. I. Evidence for its hemoprotein nature, J. Biol. Chem., 239, 2370-2378.
    • (1964) J. Biol. Chem. , vol.239 , pp. 2370-2378
    • Omura, T.1    R. Sato2
  • 36
    • 0000925644 scopus 로고
    • Different rates of spontaneous mutation during mitosis and meiosis in yeast
    • Magni, G.E. and R.C. von Borstel (1962) Different rates of spontaneous mutation during mitosis and meiosis in yeast, Genetics, 47, 1097-1108.
    • (1962) Genetics , vol.47 , pp. 1097-1108
    • Magni, G.E.1    R.C. von Borstel2
  • 37
    • 0019504288 scopus 로고
    • Evaluating statistical analysis and reproducibility of microbial mutagenicity of microbial mutagenicity assays
    • Chu, K.C., K.M. Patel, A.H. Lin, R.E. Tarone, M.S. Linhart and V.C. Dunkel (1981) Evaluating statistical analysis and reproducibility of microbial mutagenicity of microbial mutagenicity assays, Mutation Res., 85, 119-132.
    • (1981) Mutation Res. , vol.85 , pp. 119-132
    • Chu, K.C.1    K.M. Patel A.H. Lin R.E. Tarone M.S. Linhart2    V.C. Dunkel3
  • 38
    • 0018178945 scopus 로고
    • Regulation of the biosynthesis of cytochrome P-450 in brewer's yeast. Role of cyclic AMP
    • Wieseman, A., T.-K. Lim and L.F.J. Woods (1978) Regulation of the biosynthesis of cytochrome P-450 in brewer's yeast. Role of cyclic AMP, Biochem. Biophys. Acta, 544, 615-623.
    • (1978) Biochem. Biophys. Acta , vol.544 , pp. 615-623
    • Wieseman, A.1    T.-K. Lim2    L.F.J. Woods3
  • 39
    • 0019422457 scopus 로고
    • Effect of carbon source on the accumulation of cytochrome P-450 in the yeast Saccharomyces cerevisiae
    • Kärenlampi, S.O., E. Marin and O.O.P. Hänninen (1981) Effect of carbon source on the accumulation of cytochrome P-450 in the yeast Saccharomyces cerevisiae, Biochem. J., 194, 407-413.
    • (1981) Biochem. J. , vol.194 , pp. 407-413
    • Kärenlampi, S.O.1    E. Marin2    O.O.P. Hänninen3
  • 40
    • 0022002149 scopus 로고
    • Modulation in cytochrome P-420 and P-450 content in Saccharomyces cerevisiae according to physiological conditions and genetic background
    • von Borstel, R.C., D.F. O'Connell, R.D. Metha and U.G.G. Henning (1985) Modulation in cytochrome P-420 and P-450 content in Saccharomyces cerevisiae according to physiological conditions and genetic background, Mutation Res., 150, 217-224.
    • (1985) Mutation Res. , vol.150 , pp. 217-224
    • Von Borstel, R.C.1    D.F. O'Connell R.D. Metha2    U.G.G. Henning3
  • 41
    • 0018817225 scopus 로고
    • Oxygen activation by cytochrome P-450
    • White, R.E. and M.J. Coon (1980) Oxygen activation by cytochrome P-450, Annu. Rev. Biochem., 49, 315-356.
    • (1980) Annu. Rev. Biochem. , vol.49 , pp. 315-356
    • White, R.E.1    M.J. Coon2
  • 43
    • 0021846197 scopus 로고
    • 5 interactions: crosslinking of the phospholipid vesicle-associated proteins by a water-soluble carbodiimide
    • 5 interactions: crosslinking of the phospholipid vesicle-associated proteins by a water-soluble carbodiimide, Arch. Biochem. Biophys., 241, 386-396.
    • (1985) Arch. Biochem. Biophys. , vol.241 , pp. 386-396
    • Nisimoto, Y.1    J.D. Lambeth2
  • 48
    • 0026443376 scopus 로고
    • Role of chemotherapy in the future treatment of ovarian cancer
    • Ozols, R.F. (1992) Role of chemotherapy in the future treatment of ovarian cancer, Acta Obstet. Gynecol. Scand., 155, 55-60.
    • (1992) Acta Obstet. Gynecol. Scand. , vol.155 , pp. 55-60
    • Ozols, R.F.1
  • 49
    • 0022455374 scopus 로고
    • Enhancement of EMT6/SF tumor cell killing by mitomycin C and cyclophosphamide following in vivo administration of buthionine sulfoximine
    • Ono, K. and D.C. Shrieve (1986) Enhancement of EMT6/SF tumor cell killing by mitomycin C and cyclophosphamide following in vivo administration of buthionine sulfoximine, Int. J. Radiat. Oncol. Biol. Phys., 12, 1175-1178.
    • (1986) Int. J. Radiat. Oncol. Biol. Phys. , vol.12 , pp. 1175-1178
    • Ono, K.1    D.C. Shrieve2
  • 50
    • 0022547517 scopus 로고
    • Effects of glutathione depletion by buthionine sulfoximine on the sensitivity of EMT6/SF cells to chemotherapy agents or X radiation
    • Shrieve, D.C. and J.W. Harris (1986) Effects of glutathione depletion by buthionine sulfoximine on the sensitivity of EMT6/SF cells to chemotherapy agents or X radiation, Int. J. Radiat. Oncol. Biol. Phys., 12, 1171-1174.
    • (1986) Int. J. Radiat. Oncol. Biol. Phys. , vol.12 , pp. 1171-1174
    • Shrieve, D.C.1    J.W. Harris2
  • 51
    • 0022490341 scopus 로고
    • Glutathione levels and cytotoxicity of a thiol activated alkylating agent in human and mouse cells
    • Geard, C.R. and M.A. Georgsson (1986) Glutathione levels and cytotoxicity of a thiol activated alkylating agent in human and mouse cells, Int. J. Radiat. Oncol. Biol. Phys., 12, 1179-1182.
    • (1986) Int. J. Radiat. Oncol. Biol. Phys. , vol.12 , pp. 1179-1182
    • Geard, C.R.1    M.A. Georgsson2
  • 52
    • 0024787621 scopus 로고
    • Effects of systemic glutathione depletion by buthionine sulfoximine on sensitivity of murine bladder cancer to cytotoxic agents
    • Lee, K.E. and R.D. Mayer (1989) Effects of systemic glutathione depletion by buthionine sulfoximine on sensitivity of murine bladder cancer to cytotoxic agents, Urology, 34, 376-380.
    • (1989) Urology , vol.34 , pp. 376-380
    • Lee, K.E.1    R.D. Mayer2
  • 53
    • 0027366010 scopus 로고
    • In vivo therapeutic potential of combination thiol depletion and alkylating chemotherapy
    • Siemann, D.W. and K.L. Beyers (1993) In vivo therapeutic potential of combination thiol depletion and alkylating chemotherapy, Br. J. Cancer, 68, 1071-1079.
    • (1993) Br. J. Cancer , vol.68 , pp. 1071-1079
    • Siemann, D.W.1    K.L. Beyers2
  • 54
    • 0028230878 scopus 로고
    • Effects of glutathione on alkylation and cross-linking of DNA by mitomycin C. Isolation of a ternary glutathione-mitomycin-DNA adduct
    • Sharma, M., Q.-Y. He and M. Tomasz (1994) Effects of glutathione on alkylation and cross-linking of DNA by mitomycin C. Isolation of a ternary glutathione-mitomycin-DNA adduct, Chem. Res. Toxicol., 7, 401-407.
    • (1994) Chem. Res. Toxicol. , vol.7 , pp. 401-407
    • Sharma, M.1    Q.-Y. He2    M. Tomasz3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.