The inhibitory effect of vitamin E on K-ras mutation at an early stage of lung carcinogenesis in mice

European Journal of Pharmacology

Volumn 323, Issue 1, 1997, Pages 99-102

  Yano, Tomohiro ^a   Uchida, Mikako ^b   Yuasa, Mutsuko ^a   Murakami, Ayumi ^b   Hagiwara, Kiyokazu ^a   Ichikawa, Tomio ^b  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^b MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Chemoprevention; K ras; Lung cancer; Proliferating cell nuclear antigen; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; DRUG EFFECT; HUMAN CELL; LUNG CARCINOGENESIS; MALE; MOUSE; NONHUMAN; ONCOGENE K RAS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANIMALS; BLOTTING, SOUTHERN; CELL DIVISION; DISEASE MODELS, ANIMAL; GENES, RAS; LUNG; LUNG NEOPLASMS; MALE; MICE; POINT MUTATION; POLYMERASE CHAIN REACTION; SPECIFIC PATHOGEN-FREE ORGANISMS; URETHANE; VITAMIN E;

EID: 0030906568     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00094-0     Document Type: Article

References (13)

1. Higaki, I., I. Matsui-Yuasa, M. Terakura, H. Kinoshita and S. Otani, 1994, Increased spermidine or spermine level is essential for hepatocyte growth factor induced DNA synthesis in cultured rat hepatocytes, Gastroenterology 106, 1024.
2. Ichikawa, T., Y. Yano, M. Uchida, S. Otani, K. Hagiwara and T. Yano, 1996, The activation of K-ras gene at an early stage of lung tumorigenesis in mice, Cancer Lett. 107, 165.
3. Kumar, R., S. Sukumar and M. Barbacid, 1990, Activation of ras oncogenes preceding the onset of neoplasia, Science 248, 1100.
4. Kline, K. and B.G. Sanders, 1991, Anti-tumor proliferation properties of vitamin E, in: Vitamins and Minerals in the Prevention and Treatment of Cancer, ed. M.M. Jacobs (CRC Press, Boston, MA) p. 189.
5. Malkinson, A.M., 1992, Primary lung tumors in mice: an experimentally manipulable model of human adenocarcinoma, Cancer Res. 52, 2670s.
6. 1-acetyltransferase, a new biochemical marker of epithelial proliferation in rat bladder, Jpn. J. Cancer Res. 83, 1037.
7. Nelson, M.A., B.W. Futscher, T. Kinsella, J. Wymer and G.T. Bowden, 1992, Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors, Proc. Natl. Acad. Sci. USA 89, 6398.
8. Oreffo, V.I.C., H.W. Lin, R. Padmanabhan and H.P. Witschi, 1993, Ki-ras and p53 point mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors, Carcinogenesis 14, 451.
9. Said, T.K. and D. Medina, 1995, Cell cyclins and cyclin-dependent kinase activities in mouse mammary tumor development, Carcinogenesis 16, 823.
10. Wald, N.J., S.G. Thompson, J.W. Densen, J. Borehan and A. Bailey, 1987, Serum vitamin E levels and subsequent risk of cancer, Br. J. Cancer 56, 69.
11. Yano, T., G. Ishikawa and T. Ichikawa, 1993, Is vitamin E a useful agent to protect against oxy radical-promoted lung tumorigenesis in ddY mice? Carcinogenesis 14, 1133.
12. Yano, Y., T. Yano, M. Uchida, A. Murakami, M. Ogita, T. Ichikawa, S. Otani and K. Hagiwara, 1997, The inhibitory effect of vitamin E on pulmonary polyamine biosynthesis, cell proliferation and carcinogenesis in mice, Biochim. Biophys. Acta 1356, 35.
13. You, M., U. Candrian, R.R. Maronpot, G.D. Stoner and M.W. Anderson, 1989, Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse, Proc. Natl. Acad. Sci. USA 86, 3070.