Practical uses of individual pharmacokinetic parameters in drug development and clinical practice: Examples and simulations

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 22, Issue 1, 1997, Pages 1-14

  Bjornsson, T D ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG;

AREA UNDER THE CURVE; CLINICAL PRACTICE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DEVELOPMENT; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG MONITORING; HUMAN; KIDNEY CLEARANCE; MATHEMATICAL ANALYSIS; PHARMACOKINETICS; REVIEW;

EID: 0030906275     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03189779     Document Type: Review

References (8)

1. User's Guide. PharmSim™. A Pharmacokinetic Simulation Program for the Macintosh Microcomputer. Program available from: Office of Technology Transfer, Jefferson Alumni Hall, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107-6799, USA. PharmSim is also available for the PC Windows environment.
2. Bjornsson T.D. (1992): The method of relative drug accumulation: a simple method for illustrating the effects of different drug dosage regimens and variability in drug elimination on time courses of drug concentrations. Clin Pharm. Ther., 51, 266-270.
3. Bjornsson T.D. (1992): Two steady-state pharmacokinetic parameters: peak to trough drug concentration ratio and time of occurrence of time-averaged concentration. J. Pharm. Sci., 81, 108-109.
4. Bjornsson T.D., Lui N., England M. (1994): Estimation of pharmacokinetic parameters for simulation of time courses of drug concentrations after oral administration. J. Clin. Pharmacol., 34, 1046-1052.
5. Blaschke T.F., Bjornsson T.D. (1996): Pharmacokinetics and pharmaco-epidemiology. New York, Scientific American Medicine, Scientific American, Section VI, Chapter VI, pp. 1-12.
6. Bjornsson T.D., Cocchetto D.M., McGowan F.X., Verghese C.P., Sedor F. (1983): Nomogram for estimating creatinine clearance from serum creatinine. Clin. Pharmacokinet., 8, 365-369.
7. Bjornsson T.D. (1986): Nomogram for drug dosage adjustment in patients with renal failure. Clin. Pharmacokinet., 11, 164-170.
8. Bjornsson T.D. (1996): A classification system of drug action based on therapeutic effects. J. Clin. Pharmacol., 36, 669-673.