Stereoselective reductive metabolism of metyrapone and inhibitory activity of metyrapone metabolites, metyrapol enantiomers, on steroid 11β- hydroxylase in the rat

Biological and Pharmaceutical Bulletin

Volumn 20, Issue 2, 1997, Pages 188-192

  Nagamine, Sachiko ^a   Horisaka, Eri ^a   Fukuyama, Yukari ^a   Maetani, Kiyomi ^a   Matsuzawa, Ryo ^a   Iwakawa, Seigo ^a   Asada, Shozo ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

11 hydroxylase; enantiometric metabolite; metyrapone; pharmacokinetics; rat adrenal; stereoselective reduction

Indexed keywords

METYRAPONE; STEROID 11BETA MONOOXYGENASE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONFORMATIONAL TRANSITION; DRUG BLOOD LEVEL; DRUG CONFORMATION; DRUG EFFECT; DRUG METABOLISM; ENZYME INHIBITION; HUMAN; MALE; MOUSE; STEREOCHEMISTRY;

EID: 0030906140     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.20.188     Document Type: Article

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