The lack of effect of baclofen on action potentials of spinal motor axon collateral terminations in vivo

Experimental Brain Research

Volumn 114, Issue 1, 1997, Pages 184-187

  Curtis, D R ^a   Lacey, G ^a  

^a Biology and Environment   (Australia)

Author keywords

Action potentials; Baclofen; Cat; Motor axon collateral terminations; Spinal cord; Transmitter release

Indexed keywords

BACLOFEN; CALCIUM ION;

ANIMAL EXPERIMENT; ARTICLE; CAT; FEMALE; MALE; MOTOR NERVE; NERVE FIBER; NERVE POTENTIAL; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; RENSHAW CELL; SPINAL CORD VENTRAL HORN; SPINAL NERVE; SYNAPSE;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMALS; AXONS; BACLOFEN; CATS; FEMALE; MALE; MOTOR NEURONS; NERVE ENDINGS; REACTION TIME; SPINAL CORD; SYNAPSES;

EID: 0030906132     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005618     Document Type: Article

References (26)

1. Bowe CM, Kocsis JD, Waxman SG (1985) Differences between mammalian ventral and dorsal spinal roots in response to blockade of potassium channels during maturation. Proc R Soc Lond B Biol Sci 224:355-366
2. Bowery NG, Doble A, Hill DR, Hudson AL, Shaw JS, Turnbull MJ, Warrington R (1981) Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals. Br J Pharmacol 71:53-70
3. Brown DA, Higgins AJ, Marsh S, Smart TG (1981) Actions of GABA on mammalian neurones, axons, and nerve terminals. In: De Feudis FV, Mandel P (eds) Amino acid neurotransmitters. Raven Press, New York, pp 321-326
4. Burley ES, Jacobs RS (1981) Effects of 4-aminopyridine on nerve terminal action potentials. J Pharmacol Exp Ther 219:268-273
5. Cullheim S, Kellerth J-O (1978) A morphological study of the axons and recurrent axon collaterals of cat sciatic α-motoneurons after intracellular staining with horseradish peroxidase. J Comp Neurol 178:537-558
6. Curtis DR, Gynther BD (1986) On the probable absence of GABA receptors on the terminations of motor axon collaterals in the cat spinal cord. Exp Brain Res 64:114-118
7. Curtis DR, Lodge D (1982) The depolarization of feline ventral horn group Ia spinal afferent terminations by GABA. Exp Brain Res 46:215-233
8. Curtis DR, Ryall RW (1966a) The acetylcholine receptors of Renshaw cells. Exp Brain Res 2:66-80
9. Curtis DR, Ryall RW (1966b) The synaptic excitation of Renshaw cells. Exp Brain Res 2:81-96
10. Curtis DR, Lodge D, Bornstein JC, Peet MJ (1981) Selective effects of (-)-baclofen on spinal synaptic transmission in the cat. Exp Brain Res 42:158-170
11. Curtis DR, Lodge D, Bornstein JC, Peet MJ, Leah JD (1982) The dual effects of GABA and related amino acids on the electrical threshold of ventral horn group Ia afferent terminations in the cat. Exp Brain Res 48:387-400
12. Curtis DR, Gynther BD, Beattie DT, Lacey G (1995) An electrophysiological investigation of group Ia afferent fibres and terminations in the cat spinal cord. Exp Brain Res 106:403-417
13. Curtis DR, Gynther BD, Lacey G, Beattie DT (1997) Baclofen: reduction of presynaptic calcium influx in the cat spinal cord in vivo. Exp Brain Res 113:520-533
14. Davies J (1981) Selective depression of synaptic excitation in cat spinal neurones by baclofen: an iontophoretic study. Br J Pharmacol 72:373-384
15. Galvan M, Grate P, Bruggencate G ten (1980) Presynaptic actions of 4-aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro. Eur J Physiol 314:141-147
16. Glavinovic MI (1979) Effects of baclofen on junctional transmission in rat phrenic diaphragm preparation. Neuroscience 4: 2031-2035
17. Jack JJB, Redman SJ, Wong K (1981) Modifications to synaptic transmission at group Ia synapses on cat spinal motoneurones by 4-aminopyridine. J Physiol (Lond) 321:111-126
18. Jankowska E, Lundberg A, Rudomin P, Sykova E (1982) Effects of 4-aminopyridine on synaptic transmission in the cat spinal cord. Brain Res 240:117-129
19. Kato M, Waldmann U, Murakami S (1978) Effects of baclofen on spinal neurones of cats. Neuropharmacology 17:827-833
20. Lacey G, Curtis DR (1994) Phosphinic acid derivatives as baclofen agonists and antagonists in the mammalian spinal cord: an in vivo study. Exp Brain Res 101:59-72
21. Lagerback P-A, Ronnevi L-O, Cullheim S, Kellerth J-O (1981a) An ultrastructural study of the synaptic contacts of α-motoneurone axon collaterals. I. Contacts in lamina IX and with identified α-motoneurone dendrites in lamina VII. Brain Res 207:247-266
22. Lagerback P-A, Ronnevi L-O, Cullheim S, Kellerth J-O (1981b) An ultrastructural study of the synaptic contacts of α-motoneurone axon collaterals. II. Contacts in lamina VII. Brain Res 222:29-41
23. Lemeignan M (1973) Analysis of the effects of 4-amino pyridine on the lumbar spinal cord of the cat. II. Modifications of certain spinal inhibitory phenomena, post-tetanic potentiation and dorsal root potentials. Neuropharmacology 12:641-657
24. Neumcke B, Schwarz W, Stampfli R (1980) Differences between K channels in motor and sensory nerve fibres of the frog as revealed by fluctuation analysis. Eur J Physiol 387:9-16
25. Renshaw B (1941) Influence of discharge of motoneurons upon excitation of neighbouring motoneurons. J Neurophysiol 4: 167-183
26. Thesleff S (1980) Aminopyridines and synaptic transmission. Neuroscience 5:1423-1419