메뉴 건너뛰기




Volumn 23, Issue 1-2, 1997, Pages 1-13

Potent and selective aromatase inhibitor: In vitro and in vivo studies with s-triazine derivative SEF19

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 IMIDAZOLYL) 4,6 DIMORPHOLINO 1,3,5 TRIAZINE; 2 (IMIDAZOL 1 YL) 4,6 DIMORPHORINO 1,3,5 TRIAZINE; ANDROSTENEDIONE; AROMATASE; AROMATASE INHIBITOR; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); ESTROGEN RECEPTOR; STEROID 11BETA MONOOXYGENASE; STEROID 17ALPHA MONOOXYGENASE; STEROID 21 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 0030905739     PISSN: 07435800     EISSN: None     Source Type: Journal    
DOI: 10.1080/07435809709031838     Document Type: Article
Times cited : (5)

References (34)
  • 1
    • 0023606126 scopus 로고
    • Alterations in the metabolism of oestrogens during treatment with aminoglutethimide in breast cancer patients. Preliminary findings
    • Lønning PE, Kvinnsland S, Thorsen T, and Ueland PM, 1987 Alterations in the metabolism of oestrogens during treatment with aminoglutethimide in breast cancer patients. Preliminary findings. Clin Pharmacokinet 13:393-406.
    • (1987) Clin Pharmacokinet , vol.13 , pp. 393-406
    • Lønning, P.E.1    Kvinnsland, S.2    Thorsen, T.3    Ueland, P.M.4
  • 2
    • 0014073738 scopus 로고
    • Inhibition of adrenal corticosteroid synthesis by aminoglutethimide: Studies of the mechanism of action
    • Dexter RN, Fishman LM, Ney RL, Liddle GW, 1967 Inhibition of adrenal corticosteroid synthesis by aminoglutethimide: Studies of the mechanism of action. J Clin Endocr 27:473-480.
    • (1967) J Clin Endocr , vol.27 , pp. 473-480
    • Dexter, R.N.1    Fishman, L.M.2    Ney, R.L.3    Liddle, G.W.4
  • 3
    • 0014275019 scopus 로고
    • Aminoglutethimide inhibition of adrenal desmolase activity
    • Cohen MP, 1968 Aminoglutethimide inhibition of adrenal desmolase activity, Proc Soc Exper Biol Med 127:1086-1900.
    • (1968) Proc Soc Exper Biol Med , vol.127 , pp. 1086-1900
    • Cohen, M.P.1
  • 4
    • 0016290422 scopus 로고
    • Modifiers of steroid-hormone metabolism: A review of their chemistry, biochemistry and clinical application
    • Gower DB, 1974 Modifiers of steroid-hormone metabolism: A review of their chemistry, biochemistry and clinical application. J Steroid Biochem 5:501-523.
    • (1974) J Steroid Biochem , vol.5 , pp. 501-523
    • Gower, D.B.1
  • 5
    • 0019836937 scopus 로고
    • Suppression of estrogens with aminoglutethimide and hydrocortisone (medical adrenalectomy) as treatment of advanced breast carcinoma: A review
    • Santen RJ, 1981 Suppression of estrogens with aminoglutethimide and hydrocortisone (medical adrenalectomy) as treatment of advanced breast carcinoma: a review. Breast Cancer Res Treat 1:183-202.
    • (1981) Breast Cancer Res Treat , vol.1 , pp. 183-202
    • Santen, R.J.1
  • 6
    • 0023148339 scopus 로고
    • Use of the aromatase inhibitor 4-hydroxyandrostenedione in postmenopausal breast cancer: Optimization of therapeutic dose and route
    • Dowsett M, Goss PE, Powles TJ, Hutchinson G, Brodie AMH, Jeffcoate SL, Coombes RC, 1987 Use of the aromatase inhibitor 4-hydroxyandrostenedione in postmenopausal breast cancer: Optimization of therapeutic dose and route. Cancer Res 47:1957-1961.
    • (1987) Cancer Res , vol.47 , pp. 1957-1961
    • Dowsett, M.1    Goss, P.E.2    Powles, T.J.3    Hutchinson, G.4    Brodie, A.M.H.5    Jeffcoate, S.L.6    Coombes, R.C.7
  • 9
    • 0027230575 scopus 로고
    • Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors
    • Schieweck K, Bhatnagar AS, Batzl C, Lang M, 1993 Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors. J Steroid Biochem Molec Biol 44:633-636.
    • (1993) J Steroid Biochem Molec Biol , vol.44 , pp. 633-636
    • Schieweck, K.1    Bhatnagar, A.S.2    Batzl, C.3    Lang, M.4
  • 11
    • 0026544537 scopus 로고
    • A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer
    • Raats JI, Falkson G, Falkson HC, 1992 A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer. J Clin Oncol 10:111-116.
    • (1992) J Clin Oncol , vol.10 , pp. 111-116
    • Raats, J.I.1    Falkson, G.2    Falkson, H.C.3
  • 12
    • 0027997441 scopus 로고
    • Aromatase inhibitors in the treatment of breast cancer
    • Brodie AMH, 1994 Aromatase inhibitors in the treatment of breast cancer. J Steroid Biochem Molec Biol 49:281-287.
    • (1994) J Steroid Biochem Molec Biol , vol.49 , pp. 281-287
    • Brodie, A.M.H.1
  • 16
    • 0021094377 scopus 로고
    • Steroid 21-hydroxylase (cytochrome P-450) from porcine adrenocortical microsomes: Microsequence analysis of cysteine-containing peptides
    • Yuan P-M, Nakajin S, Haniu M, Shinoda M, Hall PF, Shively JE, 1983 Steroid 21-hydroxylase (cytochrome P-450) from porcine adrenocortical microsomes: Microsequence analysis of cysteine-containing peptides. Biochemistry 22:143-149.
    • (1983) Biochemistry , vol.22 , pp. 143-149
    • Yuan, P.-M.1    Nakajin, S.2    Haniu, M.3    Shinoda, M.4    Hall, P.F.5    Shively, J.E.6
  • 17
    • 0002302052 scopus 로고
    • Biochemical aspect of iron-sulfur linkage in non-heme iron protein, with special reference to "adrenodoxin"
    • Neilands J. B., Nyholm RS, Reinen D, and Williams RJP (eds) Springer-Verlag, Berlin
    • Kimura T, 1968 Biochemical aspect of iron-sulfur linkage in non-heme iron protein, with special reference to "adrenodoxin" In: Neilands J. B., Nyholm RS, Reinen D, and Williams RJP (eds) Structure and Bonding, vol. 5, Springer-Verlag, Berlin, pp. 1-40.
    • (1968) Structure and Bonding , vol.5 , pp. 1-40
    • Kimura, T.1
  • 18
    • 0016293443 scopus 로고
    • Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione
    • Thompson Jr. EA and Siiteri PK, 1974 Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione. J Biol Chem 249:5364-5372.
    • (1974) J Biol Chem , vol.249 , pp. 5364-5372
    • Thompson Jr., E.A.1    Siiteri, P.K.2
  • 19
    • 0027416740 scopus 로고
    • A time-dependent inactivation of aromatase by 19-substituted androst-4-ene-3,6,17-triones
    • Numazawa M, Mutsumi A, Asano N, Ito Y, 1993 A time-dependent inactivation of aromatase by 19-substituted androst-4-ene-3,6,17-triones. Steroids 58:40-46.
    • (1993) Steroids , vol.58 , pp. 40-46
    • Numazawa, M.1    Mutsumi, A.2    Asano, N.3    Ito, Y.4
  • 20
    • 0016156788 scopus 로고
    • The Stoichiometry of the conversion of cholesterol and hydroxycholesterols to pregnenolone (3β-hydroxypregn-5-en-20-one) catalyzed by adrenal cytochrome P-450
    • Shikita M, Hall PF, 1974 The Stoichiometry of the conversion of cholesterol and hydroxycholesterols to pregnenolone (3β-hydroxypregn-5-en-20-one) catalyzed by adrenal cytochrome P-450. Proc Nat Acad Sci USA 71:1441-1445.
    • (1974) Proc Nat Acad Sci USA , vol.71 , pp. 1441-1445
    • Shikita, M.1    Hall, P.F.2
  • 21
    • 0019887951 scopus 로고
    • Microsomal cytochrome P-450 from neonatal pig testis
    • Nakajin S, Hall PF, 1981 Microsomal cytochrome P-450 from neonatal pig testis. J Biol Chem 256:3871-3876.
    • (1981) J Biol Chem , vol.256 , pp. 3871-3876
    • Nakajin, S.1    Hall, P.F.2
  • 24
    • 0017190574 scopus 로고
    • Determination of the best-fit values of kinetic parameters of the Michaelis-Menten equation by the method of least squares with the Taylor expansion
    • Sakoda M, Hiromi K, 1976 Determination of the best-fit values of kinetic parameters of the Michaelis-Menten equation by the method of least squares with the Taylor expansion. J Biochem 80:547-555.
    • (1976) J Biochem , vol.80 , pp. 547-555
    • Sakoda, M.1    Hiromi, K.2
  • 25
    • 0022475441 scopus 로고
    • Purification to homogeneity of aromatase from human placenta
    • Nakajin S, Hall PF, 1986 Purification to homogeneity of aromatase from human placenta. Biochem Biophys Res Commun 134:704-710.
    • (1986) Biochem Biophys Res Commun , vol.134 , pp. 704-710
    • Nakajin, S.1    Hall, P.F.2
  • 26
    • 0000636448 scopus 로고
    • 44-androstene-3,17-dione to estrone by endocrine tissue
    • 44-androstene-3,17-dione to estrone by endocrine tissue. Biochim Biophys Acta 17:441-442.
    • (1955) Biochim Biophys Acta , vol.17 , pp. 441-442
    • Meyer, A.S.1
  • 30
    • 0025327094 scopus 로고
    • Potency and selectivity of the non-steroidal aromatase inhibitor CGS 16949A in postmenopausal breast cancer patients
    • Dowsett M, Stein RC, Mehta A, Coombes RC. 1990 Potency and selectivity of the non-steroidal aromatase inhibitor CGS 16949A in postmenopausal breast cancer patients. Clin Endocr 32:623-634.
    • (1990) Clin Endocr , vol.32 , pp. 623-634
    • Dowsett, M.1    Stein, R.C.2    Mehta, A.3    Coombes, R.C.4
  • 31
    • 0024850612 scopus 로고
    • Evidence that corticosterone is not an obligatory intermediate in aldosterone biosynthesis in the rat adrenal
    • Häusler A, Monnet G, Borer C, Bhatnagar AS, 1989 Evidence that corticosterone is not an obligatory intermediate in aldosterone biosynthesis in the rat adrenal. J Steroid Biochem 34:567-570.
    • (1989) J Steroid Biochem , vol.34 , pp. 567-570
    • Häusler, A.1    Monnet, G.2    Borer, C.3    Bhatnagar, A.S.4
  • 32
    • 0023517368 scopus 로고
    • In vitro and in vivo studies demonstrating potent and selective estrogen inhibition with the nonsteroidal aromatase inhibitor CGS 16949A
    • Steel RE, Mellor LB, Sawyer WK, Wasvary JM, Browne LJ, 1987 In vitro and in vivo studies demonstrating potent and selective estrogen inhibition with the nonsteroidal aromatase inhibitor CGS 16949A. Steroids 50:147-161.
    • (1987) Steroids , vol.50 , pp. 147-161
    • Steel, R.E.1    Mellor, L.B.2    Sawyer, W.K.3    Wasvary, J.M.4    Browne, L.J.5
  • 33
    • 0025677316 scopus 로고
    • Inhibition of aromatase in vitro and in vivo by aromatase inhibitors
    • Bhatnagar AS, Häusler A, Schieweck K, 1990 Inhibition of aromatase in vitro and in vivo by aromatase inhibitors. J Enz Inhibit 4:179-186.
    • (1990) J Enz Inhibit , vol.4 , pp. 179-186
    • Bhatnagar, A.S.1    Häusler, A.2    Schieweck, K.3
  • 34
    • 0028048979 scopus 로고
    • Effect of blocking oestrogen synthesis with a new generation aromatase inhibitor CGS 16949A on follicular maturation induced by pregnant mare serum gonadotrophin in the immature rat
    • Selvaraj N, Shetty G, Vijayalakshmi K, Bhatnagar AS, Moudgal NR, 1994 Effect of blocking oestrogen synthesis with a new generation aromatase inhibitor CGS 16949A on follicular maturation induced by pregnant mare serum gonadotrophin in the immature rat. J Endocr 142:563-570.
    • (1994) J Endocr , vol.142 , pp. 563-570
    • Selvaraj, N.1    Shetty, G.2    Vijayalakshmi, K.3    Bhatnagar, A.S.4    Moudgal, N.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.