Proline-glutamate interactions in the CNS

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 21, Issue 1, 1997, Pages 141-152

  Ortiz, Jose G ^a   Cordero, Mayra L ^a   Rosado, Arelys ^a  

^a UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

Author keywords

3H proline binding; AP 7; CGS 19755; CPP; glutamate; HA 966; NMDA

Indexed keywords

2 AMINO 7 PHOSPHONOHEPTANOIC ACID; 3 AMINO 1 HYDROXY 2 PYRROLIDINONE; 4 PHOSPHONOMETHYLPIPECOLIC ACID; DIZOCILPINE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PROLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG RECEPTOR BINDING; ISOTOPE LABELING; MALE; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; RAT; SYNAPTIC MEMBRANE; SYNAPTOSOME;

ANIMALS; CENTRAL NERVOUS SYSTEM; DRUG INTERACTIONS; GLUTAMIC ACID; MALE; MICE; MICE, INBRED C57BL; PROLINE; RATS; RATS, WISTAR;

EID: 0030905498     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(96)00164-9     Document Type: Article

References (20)

1. AULT, B., WANG, M., and YAWN, B.C., (1987). L-Proline depolarizes rat spinal motoneurones by an excitatory amino acid antagonist-sensitive mechanism. Br. J. Parmacol. 92: 319-326.
2. BARON, B.M., HARRISON, B.L., MILLER, F.P., MCDONALD, I.A., SALITURO, F.G., SCHMIDT, C.J., SORENSEN, S.M., WHITE, H.S., and PALFREYMAN, M.G., (1990) Activity of 5,7-Dichlorokynurenic Acid, A Potent Antagonist at the N-Methyl-D-aspartate Receptor-Associated Glycine Binding Site. Molec. Pharmacol. 38: 554-561.
3. COHEN, S.M., and NADLER, J.V., (1995) Proline-induced Potentiation of Synaptic Transmission is Long-lasting and NMDA Receptor-dependent. Soc. for Neuroscience, Abst. 437.5.
4. 3H]L-Proline binding to rat brain membranes by 2-amino-7-phosphono-heptanoic acid. Eur. J. of Pharmacol. 208: 179-181.
5. CURTIS, D.R., HOSLI, L., and JOHNSTON, G.A.P. (1968). A pharmacological study of the depression of spinal neurons by glycine and related amino acids. Exp. Brain Res. 6: 1-18.
6. CUTLER, N.R., SRAMEK, J.J., JHEE, S.S., HERTING, R.L., and FAKOUKI, D.T., (1994), The tolerability and efficacy of Cycloserine in Alzheimer's Disease. Abst. 33rd ACNP Annual Meeting.
7. D'SOUZA, D.C., MORRISSEY, K., ABI-SAAB, D., DAMON, D., GIL, R., KARPER, L., BENNETT, A., KRYSTAL, J., and CHARNEY, D., IV Glycine and Oral D-Cycloserine in Healthy humans: Effects on CSF Amino Acids, Plasma Hormones, Cognition and behavior. Abst. 33rd ACNP Annual Meeting.
8. FAKOUKI, D.T., ROSENTHAL, M., SANDEL, E., WILLIAMS, K., STEIN, S., WILLIAMS, J.M., SMITH, W., ENGLAND, D., HERTING, R.L., and MENDELS, J., (1994), Abst. 33rd Annual ACNP Annual Meeting.
9. FREMEAU, JR., R.T., CARON, M.G., and BLAKELY, R.D. (1992). Molecular cloning and expression of a high affinity L-Proline Transporter expressed in putative glutamatergic pathways of rat brain. Neuron 8: 915-936.
10. FREMEAU, JR., R.T., CHAN, J., POHORILLE, A., NADLER, J.V., MILNER, T.A., and PICKEL, M.V., (1995). Mammalian Brain specific L-Proline Transporter: Preferential Localization of Transporter Protein in Glutamatergic Nerve terminals in Rat Forebrain. Soc. For Neuroscience, Abst. 811.5.
11. 3H]proline to hippocampal synaptic membranes. Eur. J. Pharmacol. 130: 333-336.
12. +2 indicator with greatly improved fluorescence properties. . Biol. Chem. 260: 3440-3450.
13. HAUPTMANN, M., WILSON, D.F., and ERECINSKA, M., (1993). High affinity proline uptake in rat brain synaptosomes. FEBS Lett. 161: 301-305.
14. HENZI, V., REINCHLING, D.B., HELM, S.W. and MACDERMOTT, A.B., (1992). L-Proline activates glutamate and glycine receptors in cultured rat dorsal horn neurons. Molecular Pharmacol. 41: 793-801.
15. MCGRAW, T.S., FREMEAU, JR. R.T., and ANDERSON, K.J., (1995). Distribution of mRNA coding from the Mammalian Brain-Specific L-Proline transporter. Soc. for Neuroscience, Abst. 811.9.
16. NADLER, J.V., (1987). Sodium-dependent proline uptake in the rat hippocampal formation: association with ipsilateral-commissural projections of CA3 pyramidal cells. J. Neurochem. 49: 1155-1160.
17. NADLER, J.V., WANG A., and HAKIN, A., (1988). Toxicity of L-proline toward rat hippocampal neurons. Brain Research 456: 168-172.
18. NADLER, J.V., BRAY, S.D., and EVENSON, D.A., (1992). Autoradiographic localization of proline uptake in excitatory hippocampal pathways. Hippocampus 2: 269-278.
19. ORTIZ, J.G., NEGRON, A.E., and BRUNO, M.S., (1989). High-affinity binding of proline to mouse brain synaptic membranes. Neurochem. Res. 14: 139-142.
20. SHAFQUAT, S., HENZI, V., BLAKELY, R.D., and FREMEAU, JR., R.T., (1994). Enkephalins competitively antagonize the mammalian brain L-proline transporter. Soc., Neuroscience, Abst. 380.10.