Comparative embryotoxicity of four anthracyclines: In vitro study on their effects on glutathione status

Toxicology in Vitro

Volumn 11, Issue 1-2, 1997, Pages 33-41

  Menegola, E ^a   Broccia, M L ^a   Prati, M ^a   Ricolfi, R ^a   Giavini, E ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Anthracyclines; Embryotoxicity; Glutathione; Whole embryo culture

Indexed keywords

ANTHRACYCLINE DERIVATIVE; DAUNORUBICIN; DOXORUBICIN; EPIRUBICIN; GLUTATHIONE; IDARUBICIN; OXYGEN RADICAL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO CULTURE; EMBRYOTOXICITY; IN VITRO STUDY; NONHUMAN; RAT;

EID: 0030905359     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(96)00070-7     Document Type: Article

References (30)

1. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein. Analytical Biochemistry 72, 248-274.
2. Brown N. A. and Fabro S. (1981) Quantitation of rat embryonic development in vitro: a morphological scoring system. Teratology 24, 65-78.
3. Capranico G., Zunino F., Kohn K. W. and Pommier Y. (1990) Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity. Biochemistry 29, 562-569.
4. Chaires J. B., Fox K. R., Herrera J. E., Britt M. and Waring M. J. (1987) Site and sequence specificity of the daunomycin-DNA interaction. Biochemistry 26, 8227-8236.
5. Colombo R. and Milzani A. (1988) How does doxorubicin interfere with actin polymerization?. Biochimica et Biophysica Acta 968, 9-16.
6. Cova D., Rossini L., Monti E., Paracchini L. and Piccinini F. (1988) Detection of DNA damage induced by doxorubicin and the effect of glutathione. Archives of Toxicology (Suppl. 12), 330-333.
7. Fantel A. G., Greenway J. C. and Juchau M. R. (1985) The embryotoxicity of Adriamycin in rat embryos in vitro. Toxicology and Applied Pharmacology 80, 155-165.
8. Faustman-Watts E. M., Namkung M. J. and Juchau M. R. (1986) Modulation of the embryotoxicity in vitro of reactive metabolites of 2-acetylaminofluorene by reduced glutathione and ascorbate and via sulfatation. Toxicology and Applied Pharmacology 86, 400-410.
9. Fritzsche H., Triebel H., Chaires J. B., Dattagupta N. and Crothers D. M. (1982) Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: geometry of intercalation of iremycin and daunomycin. Biochemistry 21, 3940-3946.
10. Fujita K., Shinpo K., Yamada K., Sato T., Nimi H., Shamoto M., Nagatsu T., Takeuchi T. and Umezawa H. (1982) Reduction of adriamycin toxicity by ascorbate in mice and guinea pigs. Cancer Research 42, 309-316.
11. Giavini E., Broccia M. L., Prati M., Bellomo D. and Menegola E. (1992) Effects of ethanol and acetaldehyde on rat embryos developing in vitro. In Vitro Cellular and Developmental Biology 28A, 205-210.
12. Harris C. (1993) Glutathione biosynthesis in the postimplantation rat conceptus in vitro. Toxicology and Applied Pharmacology 120, 247-256.
13. Harris C., Stark K. L. and Juchau M. R. (1988) Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro. Teratology 37, 577-590.
14. Hiranruengchok R. and Harris C (1993) Glutathione oxidation and embryotoxicity elicited by diamide in the developing rat conceptus in vitro. Toxicology and Applied Pharmacology 120, 62-71.
15. Hissin P. and Hilf R. (1976) A fluorometric method for determination of oxidized glutathione in tissues. Analytical Biochemistry 74, 214-226.
16. Juchau M. R., Fantel A. G., Harris C. and Beyer B. K. (1986) The potential role of redox cycling as a mechanism for chemical teratogenesis. Environmental Health Perspectives 70, 131-136.
17. Kavlok R. J., Rogers E. H. and Rehnberg B. F. (1986) Renal functional teratogenesis resulting from Adriamycin exposure. Teratology 33, 213-220.
18. Keizer H. G., Pinedo H. M., Schuurhuis G. J. and Joenje H. (1990) Doxorubicin (Adriamycin): a critical review of free-radical-dependent mechanisms of cytotoxicity. Pharmacology and Therapeutics 47, 219-231.
19. Labarca C. and Paigen K. (1980) A simple, rapid and sensitive DNA assay procedure. Analytical Biochemistry 102, 344-352.
20. Mazuè G., Iatropolous M., Imondi A., Castellino S., Brughera M., Podestà A., Delia Torre P. and Moneta D. (1995) Anthracyclines: a review of general and special toxicity studies. International Journal of Oncology 7, 713-726.
21. Menegola E., Broccia M. L., Prati M. and Giavini E. (1995) Glutathione and N-acetylcysteine protection against acetaldehyde embryotoxicity in rat embryos developing in vitro. Toxicology in Vitro 9, 633-641.
22. Menegola E., Broccia M. L., Prati M., Ricolfi R. and Giavini E. (1996) Glutathione status in diabetes-induced embryopathies. Biology of the Neonate 69, 293-297.
23. Monti E., Prosperi E., Supino R. and Bottiroli G. (1995) Free radical-dependent DNA lesions are involved in the delayed cardiotoxicity induced by Adriamycin in the rat. Anticancer Research 15, 193-198.
24. Olson R. D. and Mushlin P. S. (1990) Doxorubicin cardiotoxicity: analysis of prevailing hypothesis. FASEB Journal 4, 3076-3086.
25. Roux C. and Taillemite J. L. (1971) Les effets de la Rubidomycine sur le developpement embryonnaire chez le rat Wistar et Sprague-Dawley, chez le souris Swiss et le hamster Doré. Teratology 4, 499.
26. Sinka B. K. (1989) Free radicals in anticancer drug pharmacology. Chemico-Biological Interactions 69, 293-317.
27. Thompson D. J., Molello J. A., Strebing R. J. and Dyke I. L. (1978) Teratogenicity of Adriamycin and Daunomycin in the rat and rabbit. Teratology 17, 151-157.
28. Tritton T. R. (1991) Cell surface actions of adriamycin. Pharmacology Therapeutics 49, 293-309.
29. Wong M. and Wells P. G. (1988) Effects of N-acetylcysteine on fetal development and on phenytoin teratogenicity in mice. Teratogenesis, Carcinogenesis and Mutagenesis 8, 65-79.
30. Zucker R. M., Elstein K. H., Shuey D. L., Ebron-McCoy M. and Rogers J. M. (1995) Utility of fluorescence microscopy in embryonic/fetal topographical analysis. Teratology 51, 430-434.