Channel-forming leucotoxins from Staphylococcus aureus cause severe inflammatory reactions in a rabbit eye model

Journal of Medical Microbiology

Volumn 46, Issue 6, 1997, Pages 486-494

  Siqueira, J A ^a   Speeg Schatz, C ^b   Freitas, F I S ^c   Sahel, J ^b   Monteil, H ^c   Prevost G ^c  

^a Institute Hilton Hocha   (Brazil)

^b UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCIDIN; LEUKOTOXIN; STAPHYLOCOCCUS TOXIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; EYE INFECTION; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; NONHUMAN; PRIORITY JOURNAL; RABBIT; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

EID: 0030904247     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/00222615-46-6-486     Document Type: Article

References (31)

1. Woodin AM. The staphylococcal leukocidin. In: Cohen JO (ed) The staphylococci. New York, Wiley Interscience. 1972: 281-289.
2. Woodin AM. Purification of the two components of leueoeidin from Staphylococcus aureus. Biochem J 1960; 75: 158-165.
3. Prévost G, Cribier B, Couppié et al Panton-Valentine leueoeidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities. Infect Immun 1995; 63: 4121-4129.
4. Supersac G, Prévost G, Piémont Y. Sequencing of leucocidin R from Staphylococcus aureus P83 suggests that staphylococcal leucocidins and gamma-hemolysin are members of a single, two-component family of toxins. Infect Immun 1993; 61: 580-587.
5. Panton PN, Valentine FCO. Staphylococcal toxin. Lancet 1932; 1: 506-508.
6. Finck-Barbançon V, Prévost G, Piémont Y. Improved purification of leukocidin from Staphylococcus aureus and toxin distribution among hospital strains. Res Microbiol 1991; 142: 75-85.
7. Llewellyn-Smith M, Price SA. Staphlococcus γ-haemolysin. J Pathol Bacteriol 1938; 47: 379-393.
8. Guyonnet F, Plommet M. Hémolysine gamma de Staphylococcus aureus: purification et propriétés. [Gamma hemolysin of Staphylococcus aureus: purification and properties.] Ann Iust Pasteur 1970; 118: 19-33.
9. Soboll H, Ito A, Schaeg W, Blobel H. [Leukocidin from staphylococci of different origin.] Zentralbl Bakteriol Orig A 1973; 224: 184-193.
10. Taylor AG, Bernheimer AW. Further characterization of staphylococcal gamma-hemolysin. Infect Immun 1974; 10: 54-59.
11. Cooney J, Kienle Z, Foster TJ, O'Toole PW. The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin. Infect Immun 1993; 61: 768-771.
12. Kamio Y, Rahman A, Nariya H, Ozawa T, Izaki K. The two staphyloccocal bi-component toxins, leukocidin and gamma-hemolysin, share one component in common. FEBS Lett 1993; 321: 15-18.
13. Finck-Barbançon V, Duportail G, Meunier O. Colin DA. Pore formation by a two-component leukocidin from Staphylococcusx aureus within the membrane of human polymorphonuclear leukocytes, Biochem Biophys Acta 1993; 1182: 275-282.
14. Colin DA, Mazurier I, Sire S, Finck-Barbançon V. Interaction of the two components of leukocidin from Staphylococcus aureus with human polymorphonuclear leukocyte membranes: sequential binding and subsequent activation. Infect Immun 1994; 62: 3184-3188.
15. Meunier O, Falkenrodt A, Monteil H, Colin DA. Application of flow cytometry in toxinology: pathophysiology of human polymorphonuclear leukocytes damaged by a pore-forming toxin from Staphylococcus aureus. Cytometry 1995; 21: 241-247.
16. Gladstone GP, van Heyningen WF. Staphylococcal leucocidins. Br J Exp Pathol 1957; 38: 123-137.
17. Couppié P, Cribier B, Prévost G, Grosshans E, Piémont Y. Leucocidin from Staphylococcus aureus and cutaneous infections: an epidemiologic study. Arch Dermatol 1994; 130: 1208-1209.
18. Cribier B, Prévost G, Couppié P, Finck-Barbançon V, Grosshans E, Piémont Y. Staphylococcus aures leukocidin: a new virulence factor in cutaneous infections? An epidemiological and experimental study. Dermatology 1992; 185: 175-180.
19. Ward PD, Turner WH. Identification of staphylococcal Panton-Valentine leukocidin as a potent dermonecrotic toxin. Infect Immun 1980; 28: 393-397.
20. Prévost G, Couppié P, Prévost P et al. Epidemiological data on Staphylococcus aureus strains producing synergohymenotropic toxins. J Med Microbiol 1995; 42: 237-245.
21. Hensler T, König B, Prévost G, Piémont Y, Köller M, König W. Leukotricne B4-generation and DNA fragmentation induced by leukocidin from Staphylococcus aureus: the protective role of granulocyte-macrophage colony stimulating factor (GM-CSF) and G-CSF for human neutrophils. Infect Immun 1994; 62: 2529-2535.
22. König B, Köller M, Prévost G. et al Activation of human effector cells by different bacterial toxins (leukocidin, alveolysin, erythrogenic toxin A), generation of interleukin-8. Infect Immun 1994; 62: 4831-4837.
23. Hensler T, Köller M, Prévost G, Piémont Y, König W. GTP-binding proteins are involved in the modulated activity of human neutrophils treated with the Panton-Valentine leukocidin from Staphylococcus aureus. Infect Immun 1994; 62: 5281-5289.
24. König B, Prévost G, Piémont Y, König W. Effect of Staphylococcus aureus leucocidins inflammatory mediator release from human granulocytes. J Infect Dis 1995; 171: 607-613.
25. Forster RK, Abbott RL, Gellender H. Management of endophthalmitis. Ophthalmology 1980; 87: 313-319.
26. Mao LK, Flynn HW, Miller D, Plugfelder SC. Endophthalmitis caused by Staphylococcus aureus. Am J Ophthalmol 1993; 116: 584-589.
27. Johnson MK, Hobden JA, Hagenah M, O'Calleghan RJ, Hill JM, Chen S. The role of pneumolysin in ocular infections with Streptococcus pneumoniae. Curr Eye Res 1990; 9: 1107-1114.
28. Nussenblatt RB, Palestine AG, Chan CC, Roberge F. Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology 1985; 92: 467-471.
29. Smith D, Lee EK, Saloupis P, Davis JK, Hatchell DL. Role of neutrophils in breakdown of the blood retinal barrier following intravitreal injection of platelet-activating factor. Exp. Eye Res 1994; 59: 425-432.
30. Callegan MC, Engel LS, Hill JM, O'Callaghan RJ. Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis. Infect Immun 1994; 62: 2478-2482.
31. Booth MC, Atkuri RV, Nanda SK, Iandolo JJ, Gilmore MS. Accessory gene regulator controls Staphylococcus aureus virulence in endophthalmitis. Invest Ophthalmol Vis Sci 1995; 36: 1828-1836.