HLA-DRB9 - Possible remnant of an ancient functional DRB subregion

Scandinavian Journal of Immunology

Volumn 45, Issue 5, 1997, Pages 504-510

  Gongora, R ^a   Figueroa, F ^a   O'Huigin, C ^a   Klein, J ^a,b  

^a MAX PLANCK INST FÜR BIOLOGIE   (Germany)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN;

ARTICLE; CELL LINE; DNA SEQUENCE; EVOLUTION; HLA SYSTEM; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0030903641     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-428.x     Document Type: Article

References (40)

1. Trowsdale J, Hanson I. MHC genes. In: Solheim BG, Ferrone S, Möller E, eds. The HLA System in Clinical Transplantation. Heidelberg: Springer-Verlag, 1993:41-8.
2. Klein J, Figueroa F. Evolution of the major histocompatibility complex. CRC Crit Rev Immunol 1986;6:295-386.
3. Gorski J. The HLA-DRw8 lineage was generated by a deletion in the DRB region followed by first domain diversification. J Immunol 1989;142:4041-5.
4. Böhme J, Andersson M, Andersson G, Möller E, Peterson PA, Rask L. HLA-DRβ genes vary in number between different DR specificities, whereas the number of DQβ genes is constant. J Immunol 1985;135:2149-55.
5. Kawai J, Ando A, Sato T, Nakatsuji T, Tsuji K, Inoko H. Analysis of gene structure and antigen determinants of DR2 antigens using DR gene transfer into mouse L cells. J Immunol 1989;142: 312-7.
6. Rollini P, Mach B, Gorski J. Linkage map of three HLA-DR β-chain genes: evidence for a recent duplication event. Proc Natl Acad Sci USA 1985;82:7197-201.
7. Spies T, Sorrentino R, Boss JM, Okada K, Strominger JL. Structural organization of the DR subregion of the human major histocompatibility complex. Proc Natl Acad Sci USA 1985;82:5165-9.
8. Andersson G, Larhammar D, Widmark E, Servenius B, Peterson PA, Rask L. Class II genes of the human major histocompatibility complex. J Immunol 1987;262:8748-58.
9. Gongora R, Figueroa F, Klein J. The HLA-DRB9 gene and the origin of HLA-DR haplotypes. Hum Immunol 1996;51:23-31.
10. Meunier H, Carson S, Bodmer W, Trowsdale J. An isolated β1 exon next to the DRA gene in the HLA-D region. Immunogenetics 1986; 23:172-80.
11. Fan W, Kasahara M, Gutknecht J et al. Shared class II Mhc polymorphisms between human and chimpanzees. Hum Immunol 1989;26:107-21.
12. Gyllensten U, Sundvall M, Ezcurra I, Erlich HA. Genetic diversity at class II DRB loci of the primate MHC. J Immunol 1991;146: 4368-76.
13. Slierendregt BL, van Noort JT, Bakas RM, Otting N, Jonker M, Bontrop RM. Evolutionary stability of trans-species major histocompatibility complex class II DRB lineages in humans and rhesus monkeys. Hum Immunol 1992;35:29-39.
14. Klein J. Origin of major histocompatibility complex polymorphism: the trans-species hypothesis. Hum Immunol 1987;19:155-62.
15. Arvidsson A, Svensson A, Widmark E, Andersson G, Rask L, Larhammar D. Characterization of three separated exons in the HLA class II DR region of the human major histocompatibility complex. Hum Immunol 1995;42:254-64.
16. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chainterminating inhibitors. Proc Natl Acad Sci USA 1977;74:5463-7.
17. Kimura M. A simple method for estimating evolutionary rates of base substitution through comparative studies of nucleotide sequences. J Mol Evol 1980;16:111-20.
18. Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 1987;4: 406-25.
19. Sokal RR, Michener CD. A statistical method for evaluating systematic relationships. Univ Kansas Sci Bull 1958;28:1409-38.
20. Kumar S, Tamuru K, Nei M. MEGA: Molecular evolutionary genetic analysis, version L01. University Park, PA: The Pennsylvania State University, 1993.
21. Smit AFA, Tóth G, Riggs AD, Jurka J. Ancestral, mammalian-wide subfamilies of LINE-1 repetitive sequences. J Mol Biol 1995; 246:401-17.
22. Batzer MA, Deininger PA, Hellmann-Blumberg U et al. Standardized nomenclature for Alu repeats. J Mol Evol 1996;42:3-6.
23. Rinehart FP, Ritch TG, Deininger PL, Schmid CW. Renaturation rate studies of a single family of interspersed repeated DNA sequences in human deoxyribonucleic acid. Biochemistry 1980;20: 3003-10.
24. Satta Y, Mayer WE, Klein J. HLA-DRB intron 1 sequences: implications for the evolution of HLA-DRB genes and haplotypes. Hum Immunol 1996;51:1-12.
25. Kapitanov V, Jurka J. The age of Alu subfamilies. J Mol Biol 1996; 42:59-65.
26. Singer MF. SINEs and LINEs: highly repetitive short and long interspersed sequences in mammalian genomes. Cell 1982;28: 433-4.
27. Kuplan DJ, Jurka J, Solus JF, Duncan CH. Medium reiteration frequency repetitive sequences in the human genome. Nucl Acid Res 1991;19:4731-8.
28. McNaughton JC, Marshall CJ, Broom JE et al. Phylogenetic relationships among transposon-like elements in human and primate DNA. J Mol Evol 1995;40:127-35.
29. Smit AFA. Identification of a new abundant superfamily of mammalian LTR-retrotransposons. Nucl Acid Res 1993;21:1863-72.
30. Lehrman MA, Goldstein JL, Russell DW, Brown MS. Duplication of seven exons in LDL receptor gene caused by Alu-Au recombination in a subject with familial hypercholesterolemia. Cell 1987;48: 827-35.
31. Lakich D, Kazazian HH, Antonakis SF, Gitschier J. Inversions disrupting the factor VIII gene are a common cause of severe haemophilia A. Nature Genetics 1993;5:236-41.
32. Satta Y, Mayer WE, Klein J. Evolutionary relationships on HLA-DRB genes inferred from intron sequences. J Mol Evol 1996;42: 648-57.
33. Brändle U, Ono H, Vincek V et al. Trans-species evolution of Mhc-DRB haplotype polymorphism in primates: organization of DRB genes in chimpanzee. Immunogenetics 1992;36:39-48.
34. Kasahara M, Klein D, Vincek V, Sarapata D, Klein J. Comparative anatomy of the primate major histocompatibility complex DR subregion: evidence for combinations of DRB genes conserved across species. Genomics 1992;14:340-9.
35. Schönbach C, Vincek V, Mayer WE, Golubic M, O'hUigin C, Klein J. Multiplication of Mhc-DRB5 loci in the orangutan: implications for the evolution of DRB haplotypes. Mamm Genome 1993; 4:159-70.
36. Slierendregt BL, Otting N, Besouw N, Jonker M, Bontrop R. Expansion and contraction of rhesus macaque DRB regions by duplication and deletion. J Immunol 1994;152:2298-306.
37. Trtkova K, Kupfermann H, Grahovac B et al. Mhc-DRB genes of platyrrhine primates. Immunogenetics 1993;38:210-17.
38. Figueroa F, O'Huigin C, Tichy H, Klein J. The origin of primate Mhc-DRB genes and allelic lineages as deduced from the study of prosimians. J Immunol 1994;152:4455-65.
39. Mayer WE, O'Huigin C, Klein J. Resolution of the HLA-DRB6 puzzle: a case of grafting a de novo-generated exon on an existing gene. Proc Natl Acad Sci USA 1993;90:10720-4.
40. O'Huigin C, Klein J. The age and evolution of the DRB pseudogenes. In: Klein J, Klein D, eds. Molecular Evolution of the Major Histocompatibility Complex. Heidelberg: Springer-Verlag, 1991: 287-97.