Dynamics of cell-free viral burden in HIV-1-infected patients

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 14, Issue 3, 1997, Pages 237-242

  Michael, Nelson L ^a,c   Chang, George ^b   Kim, Jerome H ^a   Birx, Deborah L ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^c NONE   (United States)

Author keywords

HIV 1; Serum RN; Viral burden

Indexed keywords

CD4 ANTIGEN; VIRUS RNA;

ARTICLE; DISEASE COURSE; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; RNA ANALYSIS; T LYMPHOCYTE SUBPOPULATION; VIRUS PATHOGENESIS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030903420     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199703010-00007     Document Type: Article

References (16)

1. Bagnarelli P, Menzo S, Valenza A, et al. Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS. J Virol 1992;66: 7328-35.
2. Furtado MR, Kingsley LA, Wolinsky SM. Changes in the viral mRNA expression pattern correlate with a rapid rate of CD4+ T-cell number decline in human immunodeficiency virus type 1-infected individuals. J Virol 1995;69:2092-100.
3. Gupta P, Ding M, Cottrill M, et al. Quantitation of human immunodeficiency virus type 1 DNA and RNA by a novel internally controlled PCR assay. J Clin Microbiol 1995;33: 1670-3.
4. Michael NL, Vahey M, Burke DS, Redfield RR. Viral DNA and mRNA expression correlate with the stage of human immunodeficiency virus (HIV) type 1 infection in humans: evidence for viral replication in all stages of HIV disease. J Virol 1992;66:310-6.
5. Michael NL, Mo T, Merzouki A, et al. Human immunodeficiency virus type 1 cellular RNA load and splicing patterns predict disease progression in a longitudinally studied cohort. J Virol 1995;69:1868-77.
6. Saksela K, Stevens C, Rubinstein P, Baltimore D. Human immunodeficiency virus type 1 mRNA expression in peripheral blood cells predicts disease progression independently of the numbers of CD4+ lymphocytes. Proc Natl Acad Sci USA 1994;91:1104-8.
7. Schnittman SM, Greenhouse JJ, Lane HC, Pierce PF, Fauci AS. Frequent detection of HIV-1-specific mRNAs in infected individuals suggests ongoing active viral expression in all stages of disease. AIDS Res Hum Retroviruses 1991;7:361-7.
8. Seshamma T, Bagasra O, Trono D, Baltimore D, Pomerantz RJ. Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1992;89:10663-7.
9. Holodniy M, Katzenstein DA, Sengupta S, et al. Detection and quantification of human immunodeficiency virus RNA in patient serum by use of the polymerase chain reaction. J Infect Dis 1991;163:862-6.
10. Piatak MJ, Saag MS, Yang LC, et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 1993;259:1749-54.
11. Henrard DR, Phillips JF, Muenz LR, et al. Natural history of HIV-1 cell-free viremia. JAMA 1995;274:554-8.
12. Hogervorst E, Jurriaans S, de Wolf F, et al. Predictors for non- and slow progression in human immunodeficiency virus (HIV) type 1 infection: low viral RNA copy numbers in serum and maintenance of high HIV-1 p24-specific but not V3-specific antibody levels. J Infect Dis 1995;171:811-21.
13. Jurriaans S, Van Gemen B, Weverling GJ, et al. The natural history of HIV-1 infection: virus load and virus phenotype independent determinants of clinical course? Virology 1994; 204:223-33.
14. Mellors JW, Kingsley LA, Rinaldo CJ, et al. Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 1995;122:573-9.
15. Birx DL, Davis C, Ruiz N, et al. Results of a phase II double-blinded, multicenter, placebo-controlled HIV therapeutic vaccine trial. XI International Conference on AIDS, Vancouver, British Columbia, Canada, 1996. Abstract Tu.A.275.
16. Holodniy M, Mole L, Winters M, Merigan TC. Diurnal and short-term stability of HIV virus load as measured by gene amplification. J Acquir Immune Defic Syndr Hum Retrovirol 1994;7:363-8.