Mechanism of action of clozapine-induced modification of motor behavior in an animal model of the ''super-off'' phenomenon

Movement Disorders

Volumn 12, Issue 2, 1997, Pages 159-166

  Dziewczapolski, G ^a   Menalled, L B ^a   Savino, M T ^a   Mora, M ^a   Stefano, F J E ^a   Gershanik, O ^a,b  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b Instituto de Investigaciones Farmacologicas   (Argentina)

Author keywords

Clozapine; Dopamine receptors; Locomotor activity; Mice

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; CLOZAPINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE 4 RECEPTOR; NEUROLEPTIC AGENT; QUINPIROLE; RECEPTOR SUBTYPE; RITANSERIN; SEROTONIN 1C RECEPTOR; SEROTONIN 2 RECEPTOR; SULPIRIDE;

AKINESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG BINDING; LOCOMOTION; MALE; MOUSE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; CLOZAPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MOTOR ACTIVITY; NEURAL INHIBITION; PARKINSON DISEASE, SECONDARY; PSYCHOMOTOR PERFORMANCE; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; RECEPTORS, SEROTONIN; SYNAPTIC TRANSMISSION;

EID: 0030903230     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.870120205     Document Type: Article

References (3)

1. Merello M, Lees AJ. Beginning-of-dose motor deterioration following the acute administration of levodopa and apomorphine in Parkinson's disease. J Neurol Neurosurg Psychiatry 1992;55: 1024-1026.
2. Gershanik O, Lera G, Gomez Arevalo G. Clinical profile of parkinsonian patients with super off phenomenon. Neurology 1994; 44:248.
3. Nutt JG, Gancher SX, Woodward WR. Does an inhibitory action of levodopa contribute to motor fluctuations? Neurology 1988;38: 1553-1557.