Increased expression of telomerase RNA component is associated with increased cell proliferation in human astrocytomas

American Journal of Pathology

Volumn 150, Issue 4, 1997, Pages 1159-1164

  Sallinen, Pauli ^a   Miettinen, Helena ^b   Sallinen, Satu Leena ^a   Haapasalo, Hannu ^a   Helin, Heikki ^a   Kononen, Juha ^b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

RNA; TELOMERASE;

ANIMAL CELL; ARTICLE; ASTROCYTOMA; CANCER GROWTH; CARCINOGENESIS; CELL PROLIFERATION; DNA REPLICATION; GLIOBLASTOMA; HUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA SYNTHESIS;

ASTROCYTOMA; BRAIN NEOPLASMS; CELL DIVISION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; RNA, NEOPLASM; TELOMERASE;

EID: 0030903129     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Blackburn EH: Structure and function of telomeres. Nature 1991, 350:569-573
2. Harley CB, Futcher AB, Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345: 458-460
3. Harley CB: Telomere loss: mitotic clock or genetic time bomb? Mutat Res 1991, 256:271-282
4. Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB: Telomere end-replication problem and cell aging. J Mol Biol 1992, 225:951-960
5. Wright WE, Shay JW: Telomere positional effects and the regulation of cellular senescence. Trends Genet 1992, 8:193-197
6. Rhyu MS: Telomeres, telomerase, and immortality. J Natl Cancer Inst 1995, 87:884-894
7. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL, Shay JW: Specific association of human telomerase activity with immortal cells and cancer, Science 1994, 266:2011-2015
8. Langford LA, Piatyszek MA, Xu R, Schold SC Jr, Shay JW: Telomerase activity in human brain tumors. Lancet 1995, 346:1267-1268
9. Singer MS, Gottschling DE: TLC1: template RNA component of Saccftaromyces cerevisiae telomerase. Science 1994, 266:404-409
10. McEachern MJ, Blackburn EH: Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 1995, 376:403-409
11. Feng J, Funk WD, Wang S-S, Weinrich SL, Avilion AA, Chiu C-P, Adams RR, Chang E, Allsopp RC, Yu J, Le S, West MD, Harley CB, Andrews WH, Greider CW, Ville-ponteau B: The RNA component of human telomerase. Science 1995, 269:1236-1241
12. Kleihues P, Burger PC, Scheithauer BW: Histopathological typing of tumours of the central nervous system. Geneva, World Health Organization, 1993
13. Cattoretti G, Becker MHG, Key G, Duchrow M, Schlüter C, Galle J, Gerdes J: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MlB-3) detect proliferating cells in microwave-processed formalin-fixed paraffin-embedded sections. J Pathol 1992, 168:357-363
14. Sallinen PK, Haapasalo HK, Visakorpi T, Helén PT, Rantala IS, Isola JJ, Helin HJ: Prognostication of astrocytoma patient survival by Ki-67 (MIB-1), PCNA, and S-phase fraction using archival paraffin-embedded samples. J Pathol 1994, 174:275-282
15. Blasco MA, Rizen M, Greider CW, Hanahan D: Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis, Nature Genet 1996, 12:200-204